MULSOPS: Multivariate Optimized Pit Shells Simulator for tactical mine planning

Abstract

Production planning, scheduling and allocation of resources in large-scale surface mining operations present a great challenge to mine planning engineers. Ore and waste extraction plans must be executed to achieve tactical objectives using appropriate tools. Many production planning and scheduling and resource allocation methods are based on trial and error, crisis management or subjective judgements with no detailed economic basis or mathematical rigour. In addition, these methods do not consider the random processes governing critical development and production variables. In this study, the authors develop a multivariate pit shell simulator, MULSOPS, which addresses these problems. Rigorous geometric formulations of the ellipsoidal approximations of the pit shells geometry, their expansions and sequential interactions are modeled to mimic material displacement dynamics in an open pit operation. Stochastic and numerical modeling techniques are used to provide solutions to the time-dependent geometric models in random multivariate states Under different production and economic paradigms, the geometric models are simulated to yield the source and characteristics of appropriate cuts. Combined production from successive exposed cuts provides periodic targets for tactical planning. Variance simulation is also used to provide analysts with sensitive stochastic variables for input data definition and tight production target tolerance. A numerical example is used to illustrate the use of MULSOPS for tactical planning in a typical open pit operation.     

Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

We report the investigation of the mechanical properties of different types of amyloid fibrils by the peak force quantitative nanomechanical (PF-QNM) technique. We demonstrate that this technique correctly measures the Young's modulus independent of the polymorphic state and the cross-sectional structural details of the fibrils, and we show that values for amyloid fibrils assembled from heptapeptides, α-synuclein, Aβ(1-42), insulin, β-lactoglobulin, lysozyme, ovalbumin, Tau protein and bovine serum albumin all fall in the range of 2-4 GPa.     

Characterization of antibacterial polyethersulfone membranes using the respiration activity monitoring system (RAMOS)

Membranes with antibacterial properties were developed using surface modification of polyethersulfone ultrafiltration membranes. Three different modification strategies using polyelectrolyte layer-by-layer (LbL) technique are described. The first strategy relying on the intrinsic antibacterial properties of poly(diallyldimethylammonium chloride) (PDADMAC) and poly(ethylenimine) (PEI) exhibits only little antibacterial effects. The other two strategies contain silver in both ionic (Ag⁺) and metallic (Ag⁰) form. Ag⁺ embedded into negatively charged poly(sodium 4-styrene sulfonate) (PSS) layers totally inhibits bacterial growth. Ag⁰ nanoparticles were introduced to the membrane surface by LbL deposition of chitosan- and poly(methacrylic acid) - sodium salt (PMA)-capped silver nanoparticles and subsequent UV or heat treatment. Antibacterial properties of the modified membranes were quantified by a new method based on the Respiration Activity Monitoring System (RAMOS), whereby the oxygen transfer rates (OTR) of E. coli K12 cultures on the membranes were monitored online. As opposed to colony forming counting method RAMOS yields more quantitative and reliable data on the antibacterial effect of membrane modification. Ag-imprinted polyelectrolyte film composed of chitosan (Ag⁰)/PMA(Ag⁰)/chitosan(Ag⁰) was found to be the most promising among the tested membranes. Further investigation revealed that the concentration and equal distribution of silver in the membrane surface plays an important role in bacterial growth inhibition.     

Evaluation of effect of paddle element stagger angle on the local velocity profiles in a twin-screw continuous mixer with viscous flow using Finite Element Method simulations

The effect of paddle element geometry, specifically a systematic change in stagger angle, on the velocity distribution of a Newtonian corn syrup was evaluated in the mixing region of a 2″ Readco continuous processor using 3D FEM simulations. Local velocities and regions of backflow were compared for three configurations of the paddle elements in the mixing region consisting of nine pairs of paddle elements with the central three being in a neutral (FLAT), staggered 45° forward (45F) or staggered 45° reverse (45R) configuration. The total material flow rate through the mixer was independent of the paddle element stagger but increased with screw speed when the mixer was operated with the barrel fully filled. The stagger angle variation caused only local disturbances in axial flow. The overall magnitudes of velocity were highest for the FLAT configuration followed by 45F and 45R. The local X and Y velocity components in the region of stagger showed no significant variation with paddle element stagger while the Z velocity component varied significantly in this region. Increased forward flow was seen for the 45F configuration while significant local backflow was seen for the 45R configuration at all positions of the paddle element rotation. The FLAT configuration had greater levels of pressure in the intermeshing region, suggesting a squeeze flow while there were not significant variations in pressure for the 45F and 45R configurations, suggesting a predominantly conveying/leakage flow in the axial direction. Variation in local flows is critical to good mixing.     

Design procedure of simple and accurate model of electric double layer capacitor (EDLC) targeting fast verification purposes of heat transfer simulations

From the macrostructure of electric double layer capacitor (EDLC) and from heat transfer point of view, the volumetric properties of EDLC act as surrounding anisotropy. The core of the supercapacitor is made of coil, which is composed of a number of turns. This coil is from the physical aspect represented as a anisotropic structure that has to be considered during the design of a 3D model. Such structure of capacitor’s core is then in axial direction geometrically and physically different comparing to radial direction. This results in diverse expression of thermal conductivities in the mentioned directions. Therefore, it is necessary to analytically determine axial and radial parts of heat conduction thus avoiding high degree of thermal model’s complexity. After mathematical analysis, this paper will also describe the procedure of design of the EDLC thermal simulation model. During development of EDLC thermal model, and for computational and simulation purposes, the CFD software, COMSOL 3.5a, has been used. The principal aim was to reach very close proximity of the simulation results as compared to measurements, and simultaneously achieve very low computational time. Targeting high degree of model’s accuracy, several alternatives of model complexity will be shown.     

Protocadherin 19 Clustering Epilepsy and Neurosteroids: Opportunities for Intervention

Steroids yield great influence on neurological development through nuclear hormone receptor (NHR)-mediated gene regulation. We recently reported that cell adhesion molecule protocadherin 19 (encoded by the PCDH19 gene) is involved in the coregulation of steroid receptor activity on gene expression. PCDH19 variants cause early-onset developmental epileptic encephalopathy clustering epilepsy (CE), with altered steroidogenesis and NHR-related gene expression being identified in these individuals. The implication of hormonal pathways in CE pathogenesis has led to the investigation of various steroid-based antiepileptic drugs in the treatment of this disorder, with mixed results so far. Therefore, there are many unmet challenges in assessing the antiseizure targets and efficiency of steroid-based therapeutics for CE. We review and assess the evidence for and against the implication of neurosteroids in the pathogenesis of CE and in view of their possible clinical benefit.     

Mercury emissions to the atmosphere from anthropogenic sources in Europe in 2000 and their scenarios until 2020

The paper reviews the current state of knowledge regarding European emissions of mercury and presents estimates of European emissions of mercury to the atmosphere from anthropogenic sources for the year 2000. This information was then used as a basis for Hg emission scenario development until the year 2020. Combustion of coal in power plants and residential heat furnaces generates about half of the European emissions being 239 tonnes. The coal combustion is followed by the production of caustic soda with the use of the Hg cell process (17%). Major points of mercury emission generation in the mercury cell process include: by-product hydrogen stream, end box ventilation air, and cell room ventilation air. This technology is now being changed to other caustic soda production technologies and further reduction of Hg emissions is expected in this connection. The third category on the list of the largest Hg emitters in Europe is cement production (about 13%). The largest emissions were estimated for Russia (the European part of the country), contributing with about 27% to the European emissions, followed by Poland, Germany, Spain, Ukraine, France, Italy and the United Kingdom. Most of these countries use coal as a major source of energy in order to meet the electricity and heat demands. In general, countries in the Central and Eastern Europe generated the main part of the European emissions in 2000. Emission reductions between 20% and 80% of the 2000 emission amounts can be obtained by the year 2020, as estimated by various scenarios.     

Novel 1,3,5-Triazinyl Aminobenzenesulfonamides Incorporating Aminoalcohol,Aminochalcone and Aminostilbene Structural Motifs as Potent Anti-VRE Agents,and Carbonic Anhydrases I,II, VII,IX, and XII Inhibitors

A series of 1,3,5-triazinyl aminobenzenesulfonamides substituted by aminoalcohol, aminostilbene, and aminochalcone structural motifs was synthesized as potential human carbonic anhydrase (hCA) inhibitors. The compounds were evaluated on their inhibition of tumor-associated hCA IX and hCA XII, hCA VII isoenzyme present in the brain, and physiologically important hCA I and hCA II. While the test compounds had only a negligible effect on physiologically important isoenzymes, many of the studied compounds significantly affected the hCA IX isoenzyme. Several compounds showed activity against hCA XII; (E)-4-{2-[(4-[(2,3-dihydroxypropyl)amino]-6-[(4-styrylphenyl)amino]-1,3,5-triazin-2-yl)amino]ethyl}benzenesulfonamide (31) and (E)-4-{2-[(4-[(4-hydroxyphenyl)amino]-6-[(4-styrylphenyl)amino]-1,3,5-triazin-2-yl)amino]ethyl}benzenesulfonamide (32) were the most effective inhibitors with K_Is = 4.4 and 5.9 nM, respectively. In addition, the compounds were tested against vancomycin-resistant Enterococcus faecalis (VRE) isolates. (E)-4-[2-({4-[(4-cinnamoylphenyl)amino]-6-[(4-hydroxyphenyl)amino]-1,3,5-triazin-2-yl}amino)ethyl]benzenesulfonamide (21) (MIC = 26.33 µM) and derivative 32 (MIC range 13.80–55.20 µM) demonstrated the highest activity against all tested strains. The most active compounds were evaluated for their cytotoxicity against the Human Colorectal Tumor Cell Line (HCT116 p53 +/+). Only 4,4’-[(6-chloro-1,3,5-triazin-2,4-diyl)bis(iminomethylene)]dibenzenesulfonamide (7) and compound 32 demonstrated an IC₅₀ of ca. 6.5 μM; otherwise, the other selected derivatives did not show toxicity at concentrations up to 50 µM. The molecular modeling and docking of active compounds into various hCA isoenzymes, including bacterial carbonic anhydrase, specifically α-CA present in VRE, was performed to try to outline a possible mechanism of selective anti-VRE activity.     

Studies in Carbohydrate Based Glues and Thickeners for Foodstuffs. Part I: Glucose - Sucrose - Apple Pectin Ternary System

Viscosities are given of aqueous solutions of α-D-glucose, sucrose, apple pectin and Arabic gum, as well as of various binary mixtures of these solutions. Aqueous mixtures of α-D-glucose and sucrose exhibit a small increase in viscosity. The addition of apple pectin to the binary mixtures gives solutions of a viscosity of Arabic gum.