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61.
62.
Monroe Scott M.; Roberts John E.; Kupfer David J.; Frank Ellen 《Canadian Metallurgical Quarterly》1996,105(3):313
Life stress was studied in relation to postrecovery attrition, symptom course, and recurrence of depression over 3 yrs. Participants were 67 individuals with recurrent depression who had responded to treatment. Life stress was assessed for the prior 12 wks at acute treatment entry (T1), initial recovery (T2), and after 17 wks of sustained recovery (T3). Severe life events at T1 predicted greater attrition, a more favorable postrecovery symptom course, and a lower likelihood of recurrence over 3 yrs. Life stress at T2 was not predictive of outcomes. Finally, undesirable life events at T3 tended to predict a worse symptom course and a higher likelihood of recurrence, particularly for individuals on medication. The findings are discussed in terms of (a) different processes influenced by life stress over time and (b) limitations of existing longitudinal research for studying the effects of life stress over prolonged intervals. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
63.
Monica L. Fernndez-Quintero Eugene F. DeRose Scott A. Gabel Geoffrey A. Mueller Klaus R. Liedl 《International journal of molecular sciences》2022,23(10)
Variable domains of camelid antibodies (so-called nanobodies or VHH) are the smallest antibody fragments that retain complete functionality and therapeutic potential. Understanding of the nanobody-binding interface has become a pre-requisite for rational antibody design and engineering. The nanobody-binding interface consists of up to three hypervariable loops, known as the CDR loops. Here, we structurally and dynamically characterize the conformational diversity of an anti-GFP-binding nanobody by using molecular dynamics simulations in combination with experimentally derived data from nuclear magnetic resonance (NMR) spectroscopy. The NMR data contain both structural and dynamic information resolved at various timescales, which allows an assessment of the quality of protein MD simulations. Thus, in this study, we compared the ensembles for the anti-GFP-binding nanobody obtained from MD simulations with results from NMR. We find excellent agreement of the NOE-derived distance maps obtained from NMR and MD simulations and observe similar conformational spaces for the simulations with and without NOE time-averaged restraints. We also compare the measured and calculated order parameters and find generally good agreement for the motions observed in the ps–ns timescale, in particular for the CDR3 loop. Understanding of the CDR3 loop dynamics is especially critical for nanobodies, as this loop is typically critical for antigen recognition. 相似文献
64.
65.
Scott F. Bradford 《Computers & Fluids》2009,38(4):851-860
Models for simulating turbulent, nonhydrostatic, free surface flow are highly complex and require the combination of several different physical phenomena. Consequently, there are many different approaches to design such a model. This paper explores ways to improve the numerical efficiency of an existing free surface flow model without severely sacrificing its accuracy. Specifically, this paper investigates alternative methods for integrating diffusion as well as extending the model to nonhydrostatic flow. 相似文献
66.
This special issue is the result of sustained and highly collaborative efforts to improve the use of remotely sensed data to inform management of protected areas. The 15 papers in the issue address a diverse range of topics. These papers provide a conceptual basis and a framework for establishing monitoring programs, techniques and methods to make operational the use of remotely sensed data, case studies, and synthesis papers liking remotely sensed data to models used to inform ecological assessments. Studies in this issue necessarily confront the universal challenges of scale, both spatial and temporal, and the sometimes tenuous link between observed patterns and significant ecological process. A clear message is that the information needs of resource managers require information across scales, and these information demands will continue to motivate advances in the collection and analysis of remotely sensed data. This compilation of papers is unusual in (1) articulating a basic, if somewhat technical, foundation of remote sensing that is required for resource managers to effectively collaborate with remote sensing specialists, and (2) providing a framework for addressing monitoring resource issues that is likely to be of interest to many remote sensing specialists. We hope these papers inspire broader use of remotely sensed data to manage the increasingly rare and valuable resources in protected areas around the world. 相似文献
67.
High speed tool steels manufactured from powder were assessed under arduous conditions of rolling contact and compared with conventional materials using an accelerated service simulation test. Metallographic investigations revealed factors influencing performance. Material manufactured from powder was generally found to be inferior to vacuum-remelted material due to poor structure, porosity, high interstitial nitrogen content and other manufacturing variables. Sound homogeneous material with uniform fine carbide distribution and gas content comparable with those of conventionally cast material appears potentially suitable for rolling bearings. The improved performance at elevated temperature may be due to metallographic changes, deleterious interstitial nitrogen content being reduced by a precipitation process. 相似文献
68.
Jason K. Iles Raminta Zmuidinaite Christoph Sadee Anna Gardiner Jonathan Lacey Stephen Harding Gregg Wallis Roshani Patel Debra Roblett Jonathan Heeney Helen Baxendale Ray Kruse Iles 《International journal of molecular sciences》2022,23(11)
The involvement of immunoglobulin (Ig) G3 in the humoral immune response to SARS-CoV-2 infection has been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) in COVID-19. The exact molecular mechanism is unknown, but it is thought to involve this IgG subtype’s differential ability to fix, complement and stimulate cytokine release. We examined the binding of convalescent patient antibodies to immobilized nucleocapsids and spike proteins by matrix-assisted laser desorption/ionization–time of flight (MALDI-ToF) mass spectrometry. IgG3 was a major immunoglobulin found in all samples. Differential analysis of the spectral signatures found for the nucleocapsid versus the spike protein demonstrated that the predominant humoral immune response to the nucleocapsid was IgG3, whilst for the spike protein it was IgG1. However, the spike protein displayed a strong affinity for IgG3 itself, as it would bind from control plasma samples, as well as from those previously infected with SARS-CoV-2, similar to the way protein G binds IgG1. Furthermore, detailed spectral analysis indicated that a mass shift consistent with hyper-glycosylation or glycation was a characteristic of the IgG3 captured by the spike protein. 相似文献
69.
Jeremy N. Bailenson Nick Yee Ph.D. Scott Brave Ph.D. Dan Merget David Koslow 《Human-Computer Interaction》2013,28(3):325-353
ABSTRACT This article examines the phenomenon of Virtual Interpersonal Touch (VIT), people touching one another via force-feedback haptic devices. As collaborative virtual environments become utilized more effectively, it is only natural that interactants will have the ability to touch one another. In the work presented here, we used relatively basic devices to begin to explore the expression of emotion through VIT. In Experiment 1, participants utilized a 2 DOF force-feedback joystick to express seven emotions. We examined various dimensions of the forces generated and subjective ratings of the difficulty of expressing those emotions. In Experiment 2, a separate group of participants attempted to recognize the recordings of emotions generated in Experiment 1. In Experiment 3, pairs of participants attempted to communicate the seven emotions using physical handshakes. Results indicated that humans were above chance when recognizing emotions via VIT but not as accurate as people expressing emotions through nonmediated handshakes. We discuss a theoretical framework for understanding emotions expressed through touch as well as the implications of the current findings for the utilization of VIT in human-computer interaction. 相似文献
70.
ABSTRACT There is great potential in enabling users to interact with digital information by integrating it with everyday physical objects. However, developing these interfaces requires programmers to acquire and abstract physical input. This is difficult, is time-consuming, and requires a high level of technical expertise in fields very different from user interface development—especially in the case of computer vision. Based on structured interviews with researchers, a literature review, and our own experience building physical interfaces, we created Papier-Mâché, a toolkit for integrating physical and digital interactions. Its library supports computer vision, electronic tags, and barcodes. Papier-Mâché introduces high-level abstractions for working with these input technologies that facilitate technology portability. We evaluated this toolkit through a laboratory study and longitudinal use in course and research projects, finding the input abstractions, technology portability, and monitoring facilities to be highly effective. 相似文献