The Involvement of Xanthone and (E)-Cinnamoyl Chromophores for the Design and Synthesis of Novel Sunscreening Agents

Excessive UV exposure contributes to several pathological conditions like skin burns, erythema, premature skin aging, photodermatoses, immunosuppression, and skin carcinogenesis. Effective protection from UV radiation may be achieved with the use of sunscreens containing UV filters. Currently used UV filters are characterized by some limitations including systemic absorption, endocrine disruption, skin allergy induction, and cytotoxicity. In the research centers all over the world new molecules are developed to improve the safety, photostability, solubility, and absorption profile of new derivatives. In our study, we designed and synthesized seventeen novel molecules by combining in the structures two chromophores: xanthone and (E)-cinnamoyl moiety. The ultraviolet spectroscopic properties of the tested compounds were confirmed in chloroform solutions. They acted as UVB or UVA/UVB absorbers. The most promising compound 9 (6-methoxy-9-oxo-9H-xanthen-2-yl)methyl (E)-3-(2,4-dimethoxyphenyl)acrylate) absorbed UV radiation in the range 290–369 nm. Its photoprotective activity and functional photostability were further evaluated after wet milling and incorporation in the cream base. This tested formulation with compound 9 possessed very beneficial UV protection parameters (SPF_{in vitro} of 19.69 ± 0.46 and UVA PF of 12.64 ± 0.32) which were similar as broad-spectrum UV filter tris-biphenyl triazine. Additionally, compound 9 was characterized by high values of critical wavelength (381 nm) and UVA/UVB ratio (0.830) thus it was a good candidate for broad-spectrum UV filter and it might protect skin against UVA-induced photoaging. Compound 9 were also shown to be photostable, non-cytotoxic at concentrations up to 50 µM when tested on five cell lines, and non-mutagenic in Ames test. It also possessed no estrogenic activity, according to the results of MCF-7 breast cancer model. Additionally, its favorable lipophilicity (miLogP = 5.62) does not predispose it to penetrate across the skin after topical application.     

Estimation of heat transfer coefficient of forced-air cooling and its experimental validation in controlled processing of forgings

Estimation of the cooling efficiency of an accelerated air for the needs of cooling of die forgings is presented. Temperature dependence of heat transfer coefficient (HTC) was calculated for different cooling conditions varied by airflow velocity, covering the range from 18 to 48?m/s. Time–temperature measurements performed on a full-scale semi-industrial cooling line provided similarity to conditions typical of industrial conveyor, which gives the results utilitarian significance in design of controlled processing (of steel forged products). Acquired HTC values, ranging from 164.7 to 298?W/m²?·?K, were validated in numerical simulation of cooling complex-shape forgings and subject to experimental verification, indicating perfect agreement with physical measurements.     

Numerical and clinical investigation on the material model of the cornea in Corvis tonometry tests: differentiation between hyperelasticity and viscoelasticity

Mechanics of Time-Dependent Materials - Non-contact tonometers, including ORA and Corvis ST, are not only used to estimate intraocular pressure (IOP) in clinical surveys but are also utilized to...     

Word Sense Induction with Closed Frequent Termsets

The article is devoted to the problem of word sense induction. We propose a method for inducing senses from a raw text corpus. The proposed sense induction algorithm (called SenseSearcher, or SnS) is based on closed frequent sets, and as a result, it provides a multilevel sense representation. To a large extent, it is a knowledge‐poor approach, as it does not need any kind of structured knowledge base about senses and there is no deep language knowledge embedded. By discovering a hierarchy of senses, the algorithm enables identifying subsenses (fine‐grained senses). SnS discovers not only frequent (dominating) senses but also infrequent ones (dominated). The method was evaluated in two main areas: lexicography and information retrieval. With the use of the SnS algorithm, we provide a tool able to induce from a textual corpus a structure of senses, with a varying number of granularity levels. In the area of information retrieval, SnS can be used for clustering search result, according to the discovered senses. The experiments have shown that SnS performs better than the methods participating in the SemEval2013 WSI Task 11 competition, and most of the known search result clustering methods.     

Indirect Determination of the Piezospectroscopic Coefficients of Ceria-Stabilized Tetragonal Zirconia Polycrystals

A method is proposed for the indirect determination of the stress dependence (expressed as piezospectroscopic (PS) coefficients) of spectroscopic bands of ceramic materials/phases. This method is based on the intimate mixture (intimate at the microstructural, grain-size level) of two phases/materials when the stress in one is independently known; it is used to determine the PS coefficients of the most intense Raman bands in ceria-stabilized tetragonal zirconia polycrystals (Ce-TZP). Different amounts of Ce-TZP were mixed with alumina and the composite pellets sintered; subsequently, the stress in alumina was determined through the PS coefficient of its R2 luminescence band and the stress in Ce-TZP derived from the static equilibrium condition. The frequency shifts of each Raman band of Ce-TZP have been plotted against the stress and the slopes provide the PS coefficients. The method has the advantage of not requiring any type of loading device (i.e., diamond anvil-cell, bending jig). Finally, the limits are also discussed, the most important one being the requirement of immiscibility of the two materials/phases.     

On consistent discretization of inertia terms for C0 structural elements with modified stiffness matrices

In the existing finite element calculations of dynamic problems using C⁰ structural elements, the inertia terms are evaluated without any reference to the modifications such as reduced integration, projections etc., typically needed in the discretization of the stiffness terms. A different discretization of inertia is discussed here. It is based on the following two observations. First, as shown in this work (at least for the beam problems), the modified stiffness matrix for a given C⁰ element can be obtained by standard, unmodified approach, in which degrees of freedom remain unchanged, but the shape functions are different. Those modified functions are of higher order and define the translational field within the element in terms of both translational and rotational parameters. Second, if standard consistent approach to the formulation of dynamic problems is to be followed, approximation of the displacement field used in the unmodified evaluation of the stiffness terms should also be used in discretization of the inertia terms. This implies that the modified higher-order functions should be employed when evaluating the element mass matrix for the C⁰ elements with modified stiffness matrices. As a consequence of this approach, consistency between formulation of the inertia and stiffness terms is restored. This leads to inertial coupling between rotational and translational degrees of freedom, which is absent in standard evaluation of inertia. It is demonstrated that this approach tends to improve accuracy of dynamic computations. © 1997 by John Wiley & Sons, Ltd.