The effects of instructional support and learner interests when learning using computer simulations

Within the scope of this study, the effectiveness of two kinds of instructional support was evaluated with regard to the learner’s interests. Two versions of a simulation program about the respiratory chain were developed, differing only in the kind of tasks provided for instructional support: One version contained problem-solving tasks, the other one contained worked-out examples. The focus was on the learner’s interest in the subject and in computers. The first goal of the study was to find to what extent computer simulations incorporating the different kinds of instructional support have positive effects on situational subject-interest. The second goal was to evaluate the interactions between the learner’s interests and the instructional support with regard to the learning results (subdivided into factual knowledge and understanding). Simulations with worked-out examples were shown to have positive effects on the learner’s situational interest in the subject. This was not found to be the case in simulations with problem-solving tasks. Regardless of the kind of instructional support, learners with little interest in the subject were able to achieve significant gains in factual knowledge. However, improvement in understanding was dependent on the kind of instructional support.     

Application of chemical equilibrium for hydrocarbon isomerization analysis

Isomerization is used in refining industry to upgrade gasoline. Since it is an important process, it is desirable to analyze the reactions that take place in the process. In this paper, the isomerization of a mixture of hydrocarbons was modeled by solving the chemical equilibrium of the system. A direct application of the chemical equilibrium solution cannot reproduce experimental results. However, when some of the system reactions are molar extent limited, the solution can reproduce published experimental data.     

Two‐dimensional fluorescence as a fingerprinting tool for monitoring wastewater treatment systems

BACKGROUND: The use of two‐dimensional (2D) fluorescence for monitoring complex biological systems requires careful assessment of the effect of chemical species present, which may be fluorescent and/or may interfere with the fluorescence response of target fluorophores. Given the complexity of fluorescence data (excitation emission matrices—EEMs), the challenge is how to recover the information embedded into those EEMs that can be related quantitatively with the observed performance of the biological processes under study. RESULTS: This work shows clearly that interference effects (such as quenching and inner filter effects) occur due to the presence of multiple species in complex biological media, such as natural water matrices, wastewaters and activated sludge. A statistical multivariate analysis is proposed to recover quantitative information from 2D fluorescence data, correlating EEMs with the observed performance. A selected case study is discussed, where 2D fluorescence spectra obtained from the effluent of a membrane bioreactor were compressed using PARAFAC and successfully correlated with the effluent chemical oxygen demand, using projection to latent structures modelling. CONCLUSION: This study demonstrates the potential of using 2D fluorescence spectroscopy as a status fingerprint. Additionally, it is shown how statistical multivariate data analysis can be used to correlate EEMs with selected performance parameters for monitoring of biological systems. Copyright © 2011 Society of Chemical Industry     

ST-Audit: guideline-based automatic auditing of electronic patient records

This work presents the ST-Audit system that audits a patient record for conformance to a particular clinical guideline. The system uses ST-Guide which models a guideline as a set of states and transitions. The audit system tries to find a path in the state/transition diagram that corresponds to the actions taken by the physician, taking into consideration issues such as the unavailability of all the data needed to evaluate the transitions. The system was used to audit an outpatient clinic regarding their procedure for hypertension treatment (using the VI JNC guideline for hypertension), and the results of the number of non-compliant actions were presented and discussed. A follow up auditing showed a small but statistically significant reduction on the number of non-compliant actions for patients treated after the first audit.     

Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today

Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed of phospholipid bilayers that carry a variety of molecules that can mediate cell communication, modulating crucial cell processes such as homeostasis, induction/dampening of inflammation, and promotion of repair. Their existence, initially suspected in 1946 and confirmed in 1967, spurred a sharp increase in the number of scientific publications. Paradoxically, the increasing interest for EV content and function progressively reduced the relevance for a precise nomenclature in classifying EVs, therefore leading to a confusing scientific production. The aim of this review was to analyze the evolution of the progress in the knowledge and definition of EVs over the years, with an overview of the methodologies used for the identification of the vesicles, their cell of origin, and the detection of their cargo. The MISEV 2018 guidelines for the proper recognition nomenclature and ways to study EVs are summarized. The review finishes with a “more questions than answers” chapter, in which some of the problems we still face to fully understand the EV function and potential as a diagnostic and therapeutic tool are analyzed.     

Young children in the aftermath of the World Trade Center attacks.

The attacks of September 11, 2001, on the World Trade Center were unprecedented acts of terrorism on U.S. soil. The disaster provides an opportunity to understand the responses of young children to a traumatic event of this proportion. This retrospective study took place within a year of the attacks and examined the relationship of levels of exposure to the World Trade Center disaster and family level predictors to trauma symptoms in a highly exposed sample of 180 young children in New York City. Data were collected through interviews with parents of children five years or younger at the time of the attacks. Primary variables included direct exposure and post 9/11 child and parent functioning, including trauma symptoms. Child trauma symptoms were related to direct exposure to the disaster, previous trauma, negative changes in parenting, and increased couple tension. Findings support the conceptualization that children's responses to traumatic events must be addressed within the caregiving context of family relationships. Clinical and preventive intervention for young children should be aimed at multiple levels of the social ecology. (PsycINFO Database Record (c) 2011 APA, all rights reserved)