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Zusammenfassung  Die Anerkennung einer Fortbildungsveranstaltung setzt voraus, dass sie dazu dient, die zur ?rztlichen Berufsausübung erforderlichen Fachkenntnisse in der vertrags?rztlichen Versorgung zu erwerben oder auszubauen. Veranstaltungen, die ausschlie?lich als Instrument zur Verbesserung der Wettbewerbsf?higkeit eines niedergelassenen Arztes dienen, sind nicht als Fortbildungsma?nahmen anerkennungsf?hig. (Leitsatz der Bearbeiterin)  相似文献   
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Objective

Acquired immune deficiency appears to be associated with serious non‐AIDS (SNA)‐defining conditions such as cardiovascular disease, liver and renal insufficiency and non‐AIDS‐related malignancies. We analysed the incidence of, and factors associated with, several SNA events in the LATINA retrospective cohort.

Materials and methods

Cases of SNA events were recorded among cohort patients. Three controls were selected for each case from cohort members at risk. Conditional logistic models were fitted to estimate the effect of traditional risk factors as well as HIV‐associated factors on non‐AIDS‐defining conditions.

Results

Among 6007 patients in follow‐up, 130 had an SNA event (0.86 events/100 person‐years of follow‐up) and were defined as cases (40 with cardiovascular events, 54 with serious liver failure, 35 with non‐AIDS‐defining malignancies and two with renal insufficiency). Risk factors such as diabetes, hepatitis B and C virus coinfections and alcohol abuse showed an association with events, as expected. The last recorded CD4 T‐cell count prior to index date (P=0.0056, with an average difference of more than 100 cells/μL) and area under the CD4 cell curve in the year previous to index date (P=0.0081) were significantly lower in cases than in controls. CD4 cell count at index date was significantly associated with the outcome after adjusting for risk factors.

Conclusions

The incidence and type of SNA events found in this Latin American cohort are similar to those reported in other regions. We found a significant association between immune deficiency and the risk of SNA events, even in patients under antiretroviral treatment.  相似文献   
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Abstrakt 1. Die Vereinbarung einer am Umsatz oder Gewinn einer Apotheke ausgerichteten Miete ist nach § 8 S. 2 ApoG unzul?ssig. Das Verbot der Umsatzmiete gilt insbesondere für die Anmietung von Apothekenbetriebsr?umen. 2. Aus dem Gesamtgefüge der Vereinbarungen kann sich ergeben, dass die Vertragsparteien die Miete am Umsatz oder Gewinn ausgerichtet haben und der Vermieter dadurch an den Ertr?gnissen der Apotheke teilhat. 3. Ein immens hoher Mietzins engt die wirtschaftliche Bewegungsfreiheit des Apothekers erheblich ein und macht ihn zumindest indirekt vom Vermieter abh?ngig. 4. Der Umstand, dass die Apothekenansiedlung im Kontext eines Medizinischen Versorgungszentrums geplant ist, ?ndert nichts an der uneingeschr?nkten Geltung des § 8 S. 2 ApoG. (Leits?tze des Bearbeiters)  相似文献   
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Innovations in design of a dedicated breast scanner resulted in automation of the scanning process, the production of high resolution images of the whole breast and an efficient mode of image review. The results of clinical evaluation of the prototype of this breast scanner investigating normal breasts as well as benign and malignant breast lesions are presented.  相似文献   
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Sex differences in mitochondrial numbers and function are present in large cerebral arteries, but it is unclear whether these differences extend to the microcirculation. We performed an assessment of mitochondria-related proteins in cerebral microvessels (MVs) isolated from young, male and female, Sprague-Dawley rats. MVs composed of arterioles, capillaries, and venules were isolated from the cerebrum and used to perform a 3 versus 3 quantitative, multiplexed proteomics experiment utilizing tandem mass tags (TMT), coupled with liquid chromatography/mass spectrometry (LC/MS). MS data and bioinformatic analyses were performed using Proteome Discoverer version 2.2 and Ingenuity Pathway Analysis. We identified a total of 1969 proteins, of which 1871 were quantified by TMT labels. Sixty-four proteins were expressed significantly (p < 0.05) higher in female samples compared with male samples. Females expressed more mitochondrial proteins involved in energy production, mitochondrial membrane structure, anti-oxidant enzyme proteins, and those involved in fatty acid oxidation. Conversely, males had higher expression levels of mitochondria-destructive proteins. Our findings reveal, for the first time, the full extent of sexual dimorphism in the mitochondrial metabolic protein profiles of MVs, which may contribute to sex-dependent cerebrovascular and neurological pathologies.  相似文献   
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Ohne Zusammenfassung  相似文献   
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