全文获取类型
收费全文 | 1697篇 |
免费 | 83篇 |
国内免费 | 3篇 |
学科分类
医药卫生 | 1783篇 |
出版年
2023年 | 5篇 |
2021年 | 22篇 |
2020年 | 19篇 |
2019年 | 25篇 |
2018年 | 29篇 |
2017年 | 28篇 |
2016年 | 42篇 |
2015年 | 31篇 |
2014年 | 42篇 |
2013年 | 79篇 |
2012年 | 90篇 |
2011年 | 84篇 |
2010年 | 55篇 |
2009年 | 44篇 |
2008年 | 107篇 |
2007年 | 123篇 |
2006年 | 84篇 |
2005年 | 97篇 |
2004年 | 71篇 |
2003年 | 96篇 |
2002年 | 100篇 |
2001年 | 23篇 |
2000年 | 23篇 |
1999年 | 19篇 |
1998年 | 31篇 |
1997年 | 14篇 |
1996年 | 34篇 |
1995年 | 38篇 |
1994年 | 14篇 |
1993年 | 36篇 |
1992年 | 37篇 |
1991年 | 24篇 |
1990年 | 28篇 |
1989年 | 8篇 |
1988年 | 17篇 |
1987年 | 18篇 |
1986年 | 17篇 |
1985年 | 14篇 |
1984年 | 14篇 |
1983年 | 14篇 |
1982年 | 10篇 |
1981年 | 8篇 |
1979年 | 6篇 |
1978年 | 10篇 |
1977年 | 6篇 |
1976年 | 7篇 |
1975年 | 4篇 |
1972年 | 7篇 |
1971年 | 3篇 |
1969年 | 4篇 |
排序方式: 共有1783条查询结果,搜索用时 140 毫秒
81.
82.
Engvall M Sjögreen L Kjellberg H Robertson A Sundell S Kiliaridis S 《European journal of oral sciences》2007,115(3):192-197
Myotonic dystrophy or dystrophia myotonica (DM) is a hereditary neuromuscular multisystem disease with a varying clinical expressivity and severity. The objective of this study was to assess the oral health in children with myotonic dystrophy and to compare it with a control group. Fifty-six DM patients, aged 2.7-18.0 yr, were compared with age- and gender-matched control patients with respect to caries, plaque, and gingivitis. Oral function and signs of temporomandibular dysfunction (TMD) were assessed, and the ability to co-operate in dental treatment was estimated. Questionnaires concerning eating habits, dental care, traumatic injuries to teeth, and orofacial function were also used. The DM patients had significantly more caries, plaque, and gingivitis than did control patients. They had more TMD problems and lower co-operation ability than the healthy control persons. General sedation was frequently needed to carry through dental treatment. DM patients are at risk of caries, gingivitis and TMD problems, and need intensified prophylactic care. Behavior management problems are common. 相似文献
83.
84.
85.
Dimberg A Rylova S Dieterich LC Olsson AK Schiller P Wikner C Bohman S Botling J Lukinius A Wawrousek EF Claesson-Welsh L 《Blood》2008,111(4):2015-2023
Selective targeting of endothelial cells in tumor vessels requires delineation of key molecular events in formation and survival of blood vessels within the tumor microenvironment. To this end, proteins transiently up-regulated during vessel morphogenesis were screened for their potential as targets in antiangiogenic tumor therapy. The molecular chaperone alphaB-crystallin was identified as specifically induced with regard to expression level, modification by serine phosphorylation, and subcellular localization during tubular morphogenesis of endothelial cells. Small interfering RNA-mediated knockdown of alphaB-crystallin expression did not affect endothelial proliferation but led to attenuated tubular morphogenesis, early activation of proapoptotic caspase-3, and increased apoptosis. alphaB-crystallin was expressed in a subset of human tumor vessels but not in normal capillaries. Tumors grown in alphaB-crystallin(-/-) mice were significantly less vascularized than wild-type tumors and displayed increased areas of apoptosis/necrosis. Importantly, tumor vessels in alphaB-crystallin(-/-) mice were leaky and showed signs of caspase-3 activation and extensive apoptosis. Ultrastructural analyses showed defective vessels partially devoid of endothelial lining. These data strongly implicate alphaB-crystallin as an important regulator of tubular morphogenesis and survival of endothelial cell during tumor angiogenesis. Hereby we identify the small heat shock protein family as a novel class of angiogenic modulators. 相似文献
86.
Anna Löf Granström Ellen Markljung Katharina Fink Edvard Nordenskjöld Daniel Nilsson Tomas Wester Agneta Nordenskjöld 《Journal of pediatric surgery》2014
Purpose
We identified a girl with Hirschsprung’s disease (HSCR) whose mother and grandmother had HSCR associated with multiple sclerosis (MS). The aim of this study was to outline mutations in HSCR-related genes and MS susceptibility alleles in these three individuals.Methods
The phenotypes were reviewed based on medical records. The three subjects had rectosigmoid HSCR verified with histopathology. The mother and grandmother fulfilled the McDonald criteria for MS. DNA was isolated from EDTA-preserved blood according to standard procedures. Exome sequencing aiming mainly at analyzing HSCR associated genes as well as Sanger sequencing for confirmation was performed.Results
All affected individuals carry a novel heterozygous nonsense mutation in the EDNRB gene (c.C397T,p.R133X,refNM_000115), changing an arginine at position 133 into a premature stop codon. None of the subjects were homozygous for the HLA risk alleles for MS.Conclusion
We report a novel non-sense EDNRB gene mutation in a girl with HSCR and her mother and grandmother with HSCR and MS. We propose that this EDNRB gene mutation plays a role in the etiology of HSCR and also makes the subjects susceptible to MS. 相似文献87.
Agneta Åkesson Susanna C. LarssonAndrea Discacciati MSc Alicja Wolk DMSc 《Journal of the American College of Cardiology》2014
Background
Adherence to a combination of healthy dietary and lifestyle practices may have an impressive impact on the primary prevention of myocardial infarction (MI).Objectives
The aim of this study was to examine the benefit of combined low-risk diet and healthy lifestyle practices on the incidence of MI in men.Methods
The population-based, prospective cohort of Swedish men comprised 45- to 79-year-old men who completed a detailed questionnaire on diet and lifestyle at baseline in 1997. In total, 20,721 men with no history of cancer, cardiovascular disease, diabetes, hypertension, or high cholesterol levels were followed through 2009. Low-risk behavior included 5 factors: a healthy diet (top quintile of Recommended Food Score), moderate alcohol consumption (10 to 30 g/day), no smoking, being physically active (walking/bicycling ≥40 min/day and exercising ≥1 h/week), and having no abdominal adiposity (waist circumference <95 cm).Results
During 11 years of follow-up, we ascertained 1,361 incident cases of MI. The low-risk dietary choice together with moderate alcohol consumption was associated with a relative risk of 0.65 (95% confidence interval [CI]: 0.48 to 0.87) compared with men having 0 of 5 low-risk factors. Men having all 5 low-risk factors compared with those with 0 low-risk factors had a relative risk of 0.14 (95% CI: 0.04 to 0.43). This combination of healthy behaviors, present in 1% of the men, could prevent 79% (95% CI: 34% to 93%) of the MI events on the basis of the study population.Conclusions
Almost 4 of 5 MIs in men may be preventable with a combined low-risk behavior. 相似文献88.
Mona Jung-König Christoph Füllenbach Michael F. Murphy Paola Manzini Stefan Laspina Kate Pendry Jörg Mühling Agneta Wikman Catherine Humbrecht Jean-Christophe Rigal Sigismond Lasocki Gilles Folléa Erhard Seifried Markus M. Müller Christof Geisen Kari Aranko Kai Zacharowski Patrick Meybohm the PaBloE working group 《Vox sanguinis》2020,115(3):182-191
89.
90.