全文获取类型
收费全文 | 58591篇 |
免费 | 3717篇 |
国内免费 | 610篇 |
学科分类
工业技术 | 62918篇 |
出版年
2024年 | 54篇 |
2023年 | 707篇 |
2022年 | 630篇 |
2021年 | 1852篇 |
2020年 | 1362篇 |
2019年 | 1431篇 |
2018年 | 1716篇 |
2017年 | 1771篇 |
2016年 | 2045篇 |
2015年 | 1628篇 |
2014年 | 2552篇 |
2013年 | 3603篇 |
2012年 | 3822篇 |
2011年 | 4502篇 |
2010年 | 3391篇 |
2009年 | 3445篇 |
2008年 | 3284篇 |
2007年 | 2703篇 |
2006年 | 2540篇 |
2005年 | 2086篇 |
2004年 | 1915篇 |
2003年 | 1987篇 |
2002年 | 1882篇 |
2001年 | 1598篇 |
2000年 | 1291篇 |
1999年 | 1174篇 |
1998年 | 1751篇 |
1997年 | 1143篇 |
1996年 | 947篇 |
1995年 | 659篇 |
1994年 | 546篇 |
1993年 | 469篇 |
1992年 | 336篇 |
1991年 | 321篇 |
1990年 | 291篇 |
1989年 | 264篇 |
1988年 | 220篇 |
1987年 | 179篇 |
1986年 | 136篇 |
1985年 | 124篇 |
1984年 | 99篇 |
1983年 | 66篇 |
1982年 | 43篇 |
1981年 | 43篇 |
1980年 | 34篇 |
1979年 | 33篇 |
1978年 | 30篇 |
1977年 | 38篇 |
1976年 | 61篇 |
1973年 | 21篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
32.
Kazuo Tsubota Stephen C. Pflugfelder Zuguo Liu Christophe Baudouin Hyo Myung Kim Elisabeth M. Messmer Friedrich Kruse Lingyi Liang Jimena Tatiana Carreno-Galeano Maurizio Rolando Norihiko Yokoi Shigeru Kinoshita Reza Dana 《International journal of molecular sciences》2020,21(23)
Over the past decades, the number of patients with dry eye disease (DED) has increased dramatically. The incidence of DED is higher in Asia than in Europe and North America, suggesting the involvement of cultural or racial factors in DED etiology. Although many definitions of DED have been used, discrepancies exist between the various definitions of dry eye disease (DED) used across the globe. This article presents a clinical consensus on the definition of DED, as formulated in four meetings with global DED experts. The proposed new definition is as follows: “Dry eye is a multifactorial disease characterized by a persistently unstable and/or deficient tear film (TF) causing discomfort and/or visual impairment, accompanied by variable degrees of ocular surface epitheliopathy, inflammation and neurosensory abnormalities.” The key criteria for the diagnosis of DED are unstable TF, inflammation, ocular discomfort and visual impairment. This definition also recommends the assessment of ocular surface epitheliopathy and neurosensory abnormalities in each patient with suspected DED. It is easily applicable in clinical practice and should help practitioners diagnose DED consistently. This consensus definition of DED should also help to guide research and clinical trials that, to date, have been hampered by the lack of an established surrogate endpoint. 相似文献
33.
34.
35.
In vivo Kinetic Biodistribution of Nano‐Sized Outer Membrane Vesicles Derived from Bacteria 下载免费PDF全文
Su Chul Jang Sae Rom Kim Yae Jin Yoon Kyong‐Su Park Ji Hyun Kim Jaewook Lee Oh Youn Kim Eun‐Jeong Choi Dae‐Kyum Kim Dong‐Sic Choi Yoon‐Keun Kim Jaesung Park Dolores Di Vizio Yong Song Gho 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(4):456-461
Evaluation of kinetic distribution and behaviors of nanoparticles in vivo provides crucial clues into their roles in living organisms. Extracellular vesicles are evolutionary conserved nanoparticles, known to play important biological functions in intercellular, inter‐species, and inter‐kingdom communication. In this study, the first kinetic analysis of the biodistribution of outer membrane vesicles (OMVs)—bacterial extracellular vesicles—with immune‐modulatory functions is performed. OMVs, injected intraperitoneally, spread to the whole mouse body and accumulate in the liver, lung, spleen, and kidney within 3 h of administration. As an early systemic inflammation response, increased levels of TNF‐α and IL‐6 are observed in serum and bronchoalveolar lavage fluid. In addition, the number of leukocytes and platelets in the blood is decreased. OMVs and cytokine concentrations, as well as body temperature are gradually decreased 6 h after OMV injection, in concomitance with the formation of eye exudates, and of an increase in ICAM‐1 levels in the lung. Following OMV elimination, most of the inflammatory signs are reverted, 12 h post‐injection. However, leukocytes in bronchoalveolar lavage fluid are increased as a late reaction. Taken together, these results suggest that OMVs are effective mediators of long distance communication in vivo. 相似文献
36.
37.
38.
39.
Machine Learning - We consider the problem of learning a binary classifier from only positive and unlabeled observations (called PU learning). Recent studies in PU learning have shown superior... 相似文献
40.
为测试倾斜摄影测量技术路线,并通过实际项目的应用,解决传统古建筑建模过程中存在的时间成本高、难以还原复杂场景等问题。按照倾斜摄影技术的技术路线,进行朱氏宗祠建筑测绘试验,并通过基于altizure软件建立三维模型来展现倾斜摄影测量技术流程。验证无人机倾斜摄影应用于古建筑三维建模的可行性和可操作性。 相似文献