Selective Al-Ti reactivity in laser-processed Al/Ti multilayers

Multilayers consisting of five (Al/Ti) bilayers were deposited on (100) silicon wafers. On top was deposited the Ti layer, aimed at preventing Al from diffusing to the surface upon laser treatment. The total thickness of the thin-film structure was 200?nm. Laser irradiations with Nd:YAG picoseconds laser pulses in the defocused regime were performed in air. Laser beam energy was 4?mJ and laser spot diameter on the sample surface was 3?mm (fluence 0.057?J?cm^?2). The samples were treated with different numbers of laser pulses. Structural characterizations were performed by different analytical methods and nano-hardness was also measured. Laser processing induced layer intermixing, formation of titanium aluminides, oxidation of the surface titanium layer and enhanced surface roughness. Aluminum appears at the sample surface only for the highest density of laser irradiation. Laser processing induces increment of nano-hardness by approximately 20% and decrease of residual Young’s modulus for a few percentages from the starting value of the untreated samples. These results can be interesting toward achieving structures with a selective extent of Al-Ti reactivity in this multilayered system, within the development of biocompatible materials.     

Defining the e-learner’s security profile: Towards awareness improvement

The paper presents an improved e-learner model that supports monitoring of user behavior related to information security. The model is built upon standardized IMS specification, according to literature research and survey conducted among e-learners. It is positioned as key part of an extended LTSA architecture in which the learner data is used to improve learner security position by continuous delivery of important information and adapting security mechanisms. The implementation is considered in Moodle LMS.     

The influence of bile salts on the distribution of simvastatin in the octanol/buffer system

Abstract

Introduction: Distribution coefficient (D) is useful parameter for evaluating drugs permeability properties across biological membranes, which are of importance for drugs bioavailability. Given that bile acids are intensively studied as drug permeation-modifying and -solubilizing agents, the aim of this study was to estimate the influence of sodium salts of cholic (CA), deoxycholic (DCA) and 12-monoketocholic acids (MKC) on distribution coefficient of simvastatin (SV) (lactone [SVL] and acid form [SVA]) which is a highly lipophilic compound with extremely low water solubility and bioavailability.

Methods: LogD values of SVA and SVL with or without bile salts were measured by liquid–liquid extraction in n-octanol/buffer systems at pH 5 and 7.4. SV concentrations in aqueous phase were determined by HPLC-DAD. Chem3D Ultra program was applied for computation of physico-chemical properties of analyzed compounds and their complexes.

Results: Statistically significant decrease in both SVA and SVL logD was observed for all three studied bile salts at both selected pH. MKC exerted the most pronounced effect in the case of SVA while there were no statistically significant differences between observed bile salts for SVL. The calculated physico-chemical properties of analyzed compounds and their complexes supported experimental results.

Conclusions: Our data indicate that the addition of bile salts into the n-octanol/buffer system decreases the values of SV distribution coefficient at both studied pH values. This may be the result of the formation of hydrophilic complexes increasing the solubility of SV that could consequently impact the pharmacokinetic parameters of SV and the final drug response in patients.     

Differences in cytocompatibility,dynamics of the oxide layers’ formation,and nickel release between superelastic and thermo-activated nickel–titanium archwires

Superelastic (SE) and thermo-activated (TA) nickel–titanium (NiTi) archwires are used in everyday orthodontic practice, based on their acceptable biocompatibility and well-defined shape memory properties. However, the differences in their surface microstructure and cytotoxicity have not been clearly defined, and the standard cytotoxicity tests are too robust to detect small differences in the cytotoxicity of these alloys, all of which can lead to unexpected adverse reactions in some patients. Therefore, we tested the hypothesis that the differences in manufacture and microstructure of commercially available SE and TA archwires may influence their biocompatibility. The archwires were studied as-received and after conditioning for 24 h or 35 days in a cell culture medium under static conditions. All of the tested archwires, including their conditioned medium (CM), were non-cytotoxic for L929 cells, but Rematitan SE (both as received and conditioned) induced the apoptosis of rat thymocytes in a direct contact. In contrast, TruFlex SE and Equire TA increased the proliferation of thymocytes. The cytotoxic effect of Rematitan SE correlated with the higher release of Ni ions in CM, higher concentration of surface Ni and an increased oxygen layer thickness after the conditioning. In conclusion, the apoptosis assay on rat thymocytes, in contrast to the less sensitive standard assay on L929 cells, revealed that Rematitan SE was less cytocompatible compared to other archwires and the effect was most probably associated with a higher exposition of the cells to Ni on the surface of the archwire, due to the formation of unstable oxide layer.     

An adaptive method based on the improved LPA-ICI algorithm for MRI enhancement

Various diseases are diagnosed using medical imaging used for analysing internal anatomical structures. However, medical images are susceptible to noise introduced in both acquisition and transmission processes. We propose an adaptive data-driven image denoising algorithm based on an improvement of the intersection of confidence intervals (ICI), called relative ICI (RICI) algorithm. The 2D mask of the adaptive size and shape is calculated for each image pixel independently, and utilized in the design of the 2D local polynomial approximation (LPA) filters. Denoising performances, in terms of the PSNR, are compared to the original ICI-based method, as well as to the fixed sized filtering. The proposed adaptive RICI-based denoising outperformed the original ICI-based method by up to 1.32 dB, and the fixed size filtering by up to 6.48 dB. Furthermore, since the denoising of each image pixel is done locally and independently, the method is easy to parallelize.     

A SLIT THROUGH PHOTOGRAPHY

Post-war experimental and conceptual photography in former Yugoslavia has only rarely been the subject of detailed study and interpretation. In considering this period, it is necessary to take into account several factors, including the absence of permanent exhibition spaces for photography, the lack of magazines in which photographic themes were presented and discussed, the impossibility of studying the field of photography and, finally, the inadequate knowledge and application of contemporary criticism and theories of photography. Nevertheless, from the mid-1950s onwards it is possible to note a variety of innovations in the field, in terms of both form and subject-matter. This article considers rare instances of institutional support for progressive photography-related events and unique, intellectual-poetic works. After the break-up of Yugoslavia, there is a dominant tendency to nationalize art created in the former state, thus ignoring the specific Yugoslav cultural field as well as the European context. Based on a methodology which surpasses the national (but still acknowledges it) and searches for meaning within the broader socio-political space to which art is referring, the research aims to change the paradigm of the peripheral position and general ignorance of the circumstances under which this innovative practice emerges.     

A high accuracy reactive power and reactive energy meter

Contents A high accuracy instrument for reactive power and reactive energy measurements in a single phase power network is described in the paper. The measurement principle is in accordance with IEC recommendation. Test results show that in the range of 1 to 100% of the input current the accuracy of the meter is better than 100 ppm for frequency variations of ±5% around the nominal frequency. The instrument could be used as a single-phase reactive power and reactive energy standard. A three phase version of the instrument could be used as a standard or as a revenue meter because of its high accuracy, simple design and anticipated low cost.

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Ein Meßgerät höher Präzision zur Blindleistungs- und Blindverbrauchsmessung

Übersicht In diesem Artikel wird ein Meßgerätu zur Blindleistungs- und Blindenergiemessung in Einphasen-Wechselstromnetzen beschrieben. Das Meßprinzip stimmt mit der Vorschrift der IEC überein. Die Meßergebnisse zeigen, daß im Bereich von 1 bis 100% des Eingangsstroms bei Frequenzvariationen von ±5% von der Nennfrequenz die Meßfehler des Gerätes kleiner als 0.01% sind. Das Meßgerät könnte als ein Normal für Blindleistungs- und Blindenergievergleichsmessungen in Einphasensystemen verwendet werden. Eine Dreiphasenversion dieses Meßgerätes könnte wegen seiner hohen Genauigkeit und des einfachen und preiswerten Aufbaus als ein Normal oder als Verbrauchsmeßgerät für die Kostenberechnung benutzt werden.

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Institute for National Measurement Standards, National Research Council     

Dynamic programming based multi-stage optimization of shunt capacitors in radial distribution systems

Contents In this paper, a new optimal procedure of the general compensation problem is proposed, by minimizing the performance criterion depending on both active power and energy losses, and by taking into account cost of shunt capacitor banks and system voltage constraints. The new solution method represents a combinatorial searching procedure, with non-differentiable optimization criterion, by using the multi-stage optimization based on dynamic programming. The applications of the method to three different test system have shown important improvements in the sense of speed and effectiveness of calculations, when compared to previously advertised solution methods.

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Mehrstufige Optimierung der Parallelkondensatoren in radialen Verteilungsnetzen mittels dynamisch Programmierung

Übersicht In diesem Artikel wird ein neues Verfahren für die allgemeine Blindleistungkompensation vrgestellt. Das Verfahren basiert auf der Minimierung der Optimalitätsbedingung, die Funktion der Wirkleistung und der Energieverluste ist. Die Kosten der Kondensatorbänke und die Betriebsgrenzen der Netzspannungen werden auch berücksichtigt. Die neue Methode stellt ein kombinatorisches Suchverfahren mit nicht-diffenzierbarer Optimalitätsbedingung dar. Dabei wird die mehrstufige Optimierung verwendet die auf der dynamischen Programmierung basiert. Die Bewertung der Methode mittels dreier Testnetze zeigt wichtige Verbesserungen bezüglich Schnelligkeit und Güte der Berechnung, im Vergleich zur früher veröffentlichten Methoden.

     

Improvements in data reduction in direct pulse heating calorimetry

This paper describes improvements introduced in data reduction in direct heating pulse specific heat experiments. In calculations of specific heat, it is necessary to calculate the first derivative of the recorded temperature data as a function of time. The error induced by different numerical differentiation techniques can represent a significant part of the overall measurement error. Thus, different digital filtering techniques, differentiation, and smoothing algorithms were applied and tested to examine their influence on the minimization of errors induced by noise, which is unavoidable in measured signals. A minimum square error criterion was applied in designing digital filters, with arbitrary prescribed magnitude characteristics. Attention was paid to applications when one or more structural phase transitions in the specimen material occur within the temperature range covered by the experiment. The cases where the frequency spectrum of induced noise overlaps with the spectrum of temperature transient signals originating from phase transitions were analyzed in detail. The effectiveness of the methods of extracting the final specific heat data from a noisy signal using different digital filtering techniques is demonstrated.Paper presented at the Fourth International Workshop on Subsecond Thermophysics, June 27–29, 1995, Köln, Germany.