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排序方式: 共有84条查询结果,搜索用时 31 毫秒
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Dmitry N. Kaluzhny Dr. Victor V. Tatarskiy Jr. Lyubov G. Dezhenkova Dr. Irina L. Plikhtyak Dr. Tatyana D. Miniker Dr. Anna K. Shchyolkina Dr. Sergey A. Strel'tsov Dr. Ghermes G. Chilov Dr. Fedor N. Novikov Dr. Irina Yu. Kubasova Dr. Zoya S. Smirnova Dr. Stalina Ya. Mel'nik Dr. Mikhail A. Livshits Dr. Olga F. Borisova Dr. Alexander A. Shtil Dr. 《ChemMedChem》2009,4(10):1641-1648
Novel indolocarbazole derivative 12‐(α‐L ‐arabinopyranosyl)indolo[2,3‐α]pyrrolo[3,4‐c]carbazole‐5,7‐dione (AIC) demonstrated high potency (at submicromolar concentrations) against the NCI panel of human tumor cell lines and transplanted tumors in vivo. In search of tentative targets for AIC, we found that the drug formed high affinity intercalative complexes with d(AT)20, d(GC)20 and calf thymus DNA (binding constants (1.6×106) M ?1≤Ka≤(3.3×106) M ?1). The drug intercalated preferentially into GC pairs of the duplex. Importantly, the concentrations at which AIC formed the intercalative complexes with DNA (C≤1 μM ) were identical to the concentrations that triggered p53‐dependent gene reporter transactivation, the replication block, the inhibition of topoisomerase I‐mediated DNA relaxation and death of HCT116 human colon carcinoma cells. We conclude that the formation of high affinity intercalative complexes with DNA is an important factor for anticancer efficacy of AIC. 相似文献
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Bulushev Dmitri A. Chuvilin Andrey L. Sobolev Vladimir I. Pirutko Larisa V. Fedoseeva Yuliya V. Lobiak Egor V. Modin Evgenii Okotrub Alexander V. Bulusheva Lyubov G. 《Topics in Catalysis》2019,62(5-6):508-517
Topics in Catalysis - Formic acid and methanol are considered as liquid organic hydrogen carriers and could be produced sustainably from biomass or by CO2 hydrogenation using catalysts. The choice... 相似文献
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Raman spectroscopy and nitrogen adsorption measurements were combined to study the surface features of semi-conducting and metallic single-wall nanotubes (SWNTs). The nanotubes were treated chemically and with heat under moderate conditions that more than doubled the mesopore volume of the tested samples, which consistently led to a significant rise in the total surface area of up to 1550 m2/g. The large increase in the number of micropores of less than 1 nm in diameter was associated with the loosening of nanotube bundles as well as the creation of structural flaws on the surface of individual SWNTs due to chemical treatment. Micropores in the 1.0-1.8 nm range were associated with the holes created on the surface of individual tubes. Heating at 1000 °C was shown to restore nanotube diameter to their initial pre-chemical treatment levels with the change in the chirality of SWNTs and diminish the porosity by closing small holes. It was assumed that the intermediate frequency range (500-1100 cm−1) was associated with the degree of imperfection of HiPco SWNTs crystalline structures, and therefore provided information about the degree of tube surface damage due to the presence of functional groups. A hypothesis explaining the transformation of SWNT porous structure during heat treatment is proposed. 相似文献
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V. R. Kopach K. S. Klepikova N. P. Klochko G. S. Khrypunov V. E. Korsun V. M. Lyubov M. V. Kirichenko A. V. Kopach 《Semiconductors》2017,51(3):335-343
We investigate the structure, surface morphology, and optical properties of nanostructured ZnO arrays fabricated by pulsed electrodeposition, Ag nanoparticles precipitated from colloidal solutions, and a ZnO/Ag nanocomposite based on them. The electronic and electrical parameters of the ZnO arrays and ZnO/Ag nanocomposites are analyzed by studying the I–V and C–V characteristics. Optimal modes for fabricating the ZnO/Ag heterostructures with the high stability and sensitivity to ultraviolet radiation as promising materials for use in photodetectors, gas sensors, and photocatalysts are determined. 相似文献
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Nair RR Ren W Jalil R Riaz I Kravets VG Britnell L Blake P Schedin F Mayorov AS Yuan S Katsnelson MI Cheng HM Strupinski W Bulusheva LG Okotrub AV Grigorieva IV Grigorenko AN Novoselov KS Geim AK 《Small (Weinheim an der Bergstrasse, Germany)》2010,6(24):2877-2884
A stoichiometric derivative of graphene with a fluorine atom attached to each carbon is reported. Raman, optical, structural, micromechanical, and transport studies show that the material is qualitatively different from the known graphene-based nonstoichiometric derivatives. Fluorographene is a high-quality insulator (resistivity >10(12) Ω) with an optical gap of 3 eV. It inherits the mechanical strength of graphene, exhibiting a Young's modulus of 100 N m(-1) and sustaining strains of 15%. Fluorographene is inert and stable up to 400 °C even in air, similar to Teflon. 相似文献
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Rahul R. Nair Wencai Ren Rashid Jalil Ibtsam Riaz Vasyl G. Kravets Liam Britnell Peter Blake Fredrik Schedin Alexander S. Mayorov Shengjun Yuan Mikhail I. Katsnelson Hui‐Ming Cheng Wlodek Strupinski Lyubov G. Bulusheva Alexander V. Okotrub Irina V. Grigorieva Alexander N. Grigorenko Kostya S. Novoselov Andre K. Geim 《Small (Weinheim an der Bergstrasse, Germany)》2010,6(24):2773-2773
A stoichiometric derivative of graphene with a fluorine atom attached to each carbon is reported. Raman, optical, structural, micromechanical, and transport studies show that the material is qualitatively different from the known graphene‐based nonstoichiometric derivatives. Fluorographene is a high‐quality insulator (resistivity >1012 Ω) with an optical gap of 3 eV. It inherits the mechanical strength of graphene, exhibiting a Young’s modulus of 100 N m?1 and sustaining strains of 15%. Fluorographene is inert and stable up to 400 °C even in air, similar to Teflon. 相似文献
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Among the carbon allotropes, carbyne chains appear outstandingly accessible for sorption and very light. Hydrogen adsorption on calcium-decorated carbyne chain was studied using ab initio density functional calculations. The estimation of surface area of carbyne gives the value four times larger than that of graphene, which makes carbyne attractive as a storage scaffold medium. Furthermore, calculations show that a Ca-decorated carbyne can adsorb up to 6 H(2) molecules per Ca atom with a binding energy of ~0.2 eV, desirable for reversible storage, and the hydrogen storage capacity can exceed ~8 wt %. Unlike recently reported transition metal-decorated carbon nanostructures, which suffer from the metal clustering diminishing the storage capacity, the clustering of Ca atoms on carbyne is energetically unfavorable. Thermodynamics of adsorption of H(2) molecules on the Ca atom was also investigated using equilibrium grand partition function. 相似文献