Computer-based extraction of the inferior alveolar nerve canal in 3-D space

Computed tomography (CT) is increasingly employed in orthodontic treatment. One of the most successful applications is in dental implantology, in which an artificial root is surgically inserted into the jawbone to provide anchorage for a dental prosthesis. For successful implant surgery, it is crucial to locate internal structures such as the inferior alveolar nerve canal (IAC). This paper presents a computerized technique for extracting the IAC. To facilitate the extraction, we first generate panoramic CT images (panoramics) by reformatting the original CT images. The panoramics are a series of cross-sectional images along curved planes through the mandible (lower jawbone). Hollow canals are subsequently detected by analyzing the voxel intensities and 3-D gradient orientations in the panoramics. The axis of the IAC is then traced out by a novel 3-D line-tracking technique. The method is effective for extracting the IAC despite the open structure of the surrounding bone.     

Composite of Au nanoparticles and molecularly imprinted polymer as a sensing material

A molecularly imprinted polymer with immobilized Au nanoparticles (Au-MIP) is reported as a novel type of sensing material. The sensing mechanism is based upon the variable proximity of the Au nanoparticles immobilized in the imprinted polymer, which exhibits selective binding of a given analyte accompanied by swelling that causes a blue-shift in the plasmon absorption band of the immobilized Au nanoparticles. Using adrenaline as the model analyte, it was shown that molecular imprinting effectively enhanced the sensitivity and selectivity, and accordingly, Au-MIP selectively detects the analyte at 5 microM. The combination of molecular imprinting and the Au nanoparticle-based sensing system was shown to be a general strategy for constructing sensing materials in a tailor-made fashion due to wide applicability of the imprinting technique and the independence of the sensing mechanism from the analyte recognition system.     

Computation of multiweight

In learning machines the key problem is to determine weight vectors satisfying linear inequalities. In two-category classification only one weight is needed, but in multicategory classification the weight vectors which have to be found are as many as the number of pattern classes. The letter shows that, for linear machines, it is necessary to find only one weight vector, which the authors call the multiweight, by applying the steepest descent method in a learning algorithm.     

Highly specific enzyme immunoassay for human chorionic gonadotropin

A highly specific enzyme immunoassay for determining hCG was established by using beta-D-galactosidase as label. In order to increase the specificity of the assay, an antiserum against whole hCG was purified on a column of hCG beta carboxyl-terminal peptide (residues 123-145) covalently linked to Sepharose 4B. The antibody (N101S) thus prepared showed a weak cross-reactivity with human LH in an assay using hCG-enzyme conjugate, but the slight cross-reactivity was virtually avoided when an hCG beta carboxyl-terminal peptide was used as a peptide in the enzyme conjugate. N101S antibody was compared with antiserum (B1B) directed against a carboxyl-terminal peptide (123-145). In hCG measurement N101S gave about 30 times higher sensitivity than B1B, although the former antibody was less sensitive to carboxyl-terminal peptides of hCG beta. The enzyme immunoassay using a combination of N101S antibody and a carboxyl-terminal peptide (130-145)-enzyme conjugate was able to detect as little as 0.25 mIU of hCG without the interference of LH. The performance and validity of this assay were comparable to those of conventional radioimmunoassay.     

Experimental exploration of discrepancies in F-number correlation of flammability limits

Flammability limits measurement has been made by ASHRAE method for some 20 kinds of combustible gases and vapors. These compounds have been selected mainly because the literature values of flammability limits are not consistent with the F-number calculated ones [J. Hazard. Mater. A 82 (2001) 113]. As a result, it has been found that the newly obtained values of flammable range are classified into three groups. For the first group of compounds, the present values agree well to the literature values. For the second group, the present values do not agree to the literature values but agree with the calculated ones. For the third group ones, the present values neither agree to the literature values nor to the calculated ones. There are 4, 13, and 6 compounds in the respective groups.     

Characterization of polymer films using a slow positron beam

Polymer structures have been investigated using positron annihilation lifetime spectroscopy (PALS) with a slow positron beam as well as a conventional radioactive source (²²Na). The properties of the free volume holes near the polymer surface were studied as a function of the positron implantation energy. The longest lifetime was associated with ortho-positronium (o-Ps) annihilation in the free volume holes. In polytetrafluoroethylene film, the lifetime of o-Ps was observed to decrease with increasing positron implantation depth, and a significant change in the o-Ps lifetime was found at a short distance (about 10 nm) from the surface, while its intensity increased. This result implies that near the polymer surface the free volume holes become larger that in the bulk. The effect of temperature on the polymer sub-surface layers was also studied. For high molecular weight polystyrene, the glass transition temperature for the sub-surface was lower than that for the bulk and thermal expansion coefficient of the sub-surface layers was found to be larger than the bulk value. Electronic Publication     

Evaluation of internal and external doses from 11C produced in the air in high energy proton accelerator tunnels

Air has been irradiated with high energy protons at the 12 GeV proton synchrotron to obtain the following parameters essential for the internal dose evaluation from airborne 11C produced through nuclear spallation reactions: the abundance of gaseous and particulate 11C, chemical forms, and particle size distribution. It was found that more than 98% of 11C is present as gas and the rest is aerosol. The gaseous components were only 11CO and 11CO2, and their proportions were approximately 80% and 20%, respectively. The particulate 11C was found to be sulphate and/or nitrate aerosols having a log-normal size distribution; the measurement using a diffusion battery showed a geometric mean radius of 0.035 micron and a geometric standard deviation of 1.8 at a beam intensity of 6.8 x 10(11) proton.pulse-1 and an irradiation time of 9.6 min. By taking the chemical composition and particle size into account, effective doses both from internal and from external exposures per unit concentration of 11C were calculated for various room sizes. The values can be used to evaluate the effective dose from the airborne 11C produced in the accelerator tunnels.     

Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties

A novel vitamin E derivative, (6″-hydroxy-2″,5″,7″,8″-tetramethylchroman-2″-yl) methyl 3-(2′,4′-dihydroxyphenyl)propionate (TM4R), which has a chromanoxyl ring and 4-substituted resorcinol moieties, was synthesized; and its inhibitory effects on tyrosinase, antioxidant ability, and lightening effect of ultraviolet B (UVB)-induced hyperpigmentation were estimated. TM4R showed potent inhibitory activity on tyrosinase, which is the rate-limiting enzyme in melanogenesis. The scavenging activities of TM4R on 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals were found to be nearly the same as those of α-tocopherol. Furthermore, an efficient lightening effect was observed following topical application of TM4R to UVB-stimulated hyperpigmented dorsal skin of brownish guinea pigs. These results suggest that TM4R may be a candidate for an efficient whitening agent, possibly by inhibiting tyrosinase activity and biological reactions caused by reactive oxygen species.     

Microstructure and press formability of a cross-rolled magnesium alloy sheet

Cross-rolling, in which the roll axis is tilted by 7.5° towards the TD-direction, was carried out on a commercial magnesium alloy. The (0002) texture intensity of the cross-rolled specimen was lower than that of the unidirectionally rolled specimen, and the (0002) texture of the cross-rolled specimen was inclined about 10° towards the TD-direction. Also, the grain size of the cross-rolled specimen was smaller than that of the unidirectionally rolled specimen. As a result of the Erichsen tests at 433-493 K, the press formability of the cross-rolled specimen was higher than that of the unidirectionally rolled specimen. The high formability of the cross-rolled specimen is attributed to both the modification of (0002) texture and the enhancement of grain refinement by the cross-rolling.     

Photoluminescence enhancement by isolating β-FeSi2 layers from defective layers

We have investigated an optimal annealing process in order to enhance 1.55 μm light emission from semiconducting β-FeSi₂ and found that two steps annealing at 600 °C and 800 °C is effective to its enhancement. Rutherford backscattering spectroscopy and SEM observations revealed that pronounced surface segregation of Fe atoms during annealing at 600 °C caused surface precipitate of β-FeSi₂. The enhancement of light emission is attributed spatial isolation of the surface β-FeSi₂ (light emitting layer) from damaged and defective layers with nonradiative recombination centers.