Rapid cellular genesis and apoptosis: Effects of exercise in the adult rat.

Long-term aerobic exercise improves cognition in both human and nonhuman animals and induces plastic changes in the central nervous system (CNS), including neurogenesis and angiogenesis. However, the early and immediate effects of exercise on the CNS have not been adequately explored. There is some evidence to suggest that exercise is initially challenging to the nervous system and that the plastic changes commonly associated with chronic exercise may result as adaptations to this challenge. The current experiment assessed levels of apoptosis, angiogenesis, and neurogenesis during the first week of an exercise regimen in the adult rat. The results indicate that exercise rapidly induces these processes in the hippocampus and cerebellum. The temporal pattern of these events suggests that voluntary exercise in the adult rat rapidly and transiently induces apoptosis, followed by angiogenesis. Neurogenesis is an immediate and independent consequence of exercise in the hippocampus that may require the additional metabolic support supplied by angiogenesis. This is the first report of CNS neuronal apoptosis as a consequence of exercise in the adult rat and suggests that this process is a potential mediator of rapid exercise-induced plasticity. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Synthesis and characterization of monodisperse uniformly shaped respirable aerosols

The top‐down, micromolding technique, referred to as Particle Replication in Nonwetting Templates (PRINT^®), affords a new opportunity for the generation of inhalation therapeutics. Powders were fabricated with predetermined particle size and shape; when dispersed with a collision jet nebulizer, these particles resulted in monodisperse aerosols with geometric standard deviations well below 1.2. Dynamic shape factors for this novel set of uniformly shaped particles were determined by correcting the drag of nonspherical particles in the ultra‐Stokesian flow conditions of the aerodynamic particle sizer (APS). This convenient approach for shape factor determination agreed well with current literature approaches and allowed for the correction of APS results for particles with known volumes. Determined shape factor values of PRINT geometries were used to estimate the theoretical median aerodynamic diameters of individual aerosols, which were then compared to actual inhalation powders. © 2013 American Institute of Chemical Engineers AIChE J, 59: 3184–3194, 2013     

Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury

Acute kidney injury (AKI) is a public health problem worldwide. Sirtuins are a family of seven NAD+-dependent deacylases, Overexpression of Sirtuin 1, 3, and 5 protect against AKI. However, the role of Sirtuin 7 (Sirt7) in AKI is not known. Here, we analyzed how Sirt7 deficient mice (KO-Sirt7) were affected by AKI. As expected, wild-type and Sirt7 heterozygotes mice that underwent renal ischemia/reperfusion (IR) exhibited the characteristic hallmarks of AKI: renal dysfunction, tubular damage, albuminuria, increased oxidative stress, and renal inflammation. In contrast, the KO-Sirt7+IR mice were protected from AKI, exhibiting lesser albuminuria and reduction in urinary biomarkers of tubular damage, despite similar renal dysfunction. The renoprotection in the Sirt7-KO+IR group was associated with reduced kidney weight, minor expression of inflammatory cytokines and less renal infiltration of inflammatory cells. This anti-inflammatory effect was related to diminished p65 expression and in its active phosphorylation, as well as by a reduction in p65 nuclear translocation. Sirt7 deficient mice are protected from AKI, suggesting that this histone deacetylase promotes tubular damage and renal inflammation. Therefore, our findings indicate that Sirt7 inhibitors may be an attractive therapeutic target to reduce NFκB signaling.     

Nature Abhors a Vacuum: Highly Diverse Mechanisms Enable Spoilage Fungi to Disperse,Survive, and Propagate in Commercially Processed and Preserved Foods

Fungal spoilage in processed foods remains a challenge for food manufacturers despite the increasing availability of diverse processing and formulation strategies used to control foodborne microorganisms. Physiological features of yeasts and molds contribute to their tolerance to thermal processing, acidity, desiccation, and oxygen and nutrient limitations. These features variably include growth form, cell wall structure, cytoplasmic composition, cell membrane‐bound proteins, and secretion of secondary metabolites. Collectively, these mechanisms contribute to the ability of fungi to disperse, survive, and propagate in highly restrictive food environments. The diversity of fungal growth and survival mechanisms has resulted in organisms adapted to nearly all food environments; although, only a small subset of fungi are particularly suited for spoilage of a given product. The relationship between the individual physiology and metabolic capabilities of a yeast or mold and the product's specific physicochemical attributes and processing history determines spoilage potential. Explicit characterization of the fungal features responsible for this extremotolerance contributes to more targeted and effective control strategies.     

Linking individual development and social changes.

In this article we argue for the need to develop a more adequate understanding of the connections between psychological research subjects' experience of social history and their personality development. We present the outlines of a general model according to which individuals' relative receptivity to the impact of social events is mediated by their life stage. Secondary analyses based on several data sets illustrate how women's work and family lives may be understood in terms of the general model. These analyses include data collected over the past 40 years from women in birth cohorts ranging from World War I to the baby boom. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Very long-term memories of the first year in college.

College alumnae who had graduated 2, 12, or 22 years earlier completed questionnaires in which they recounted the first four memories to come to mind of their freshman year and provided ratings of each remembered experience. For all three alumnae groups, the temporal distribution of memories peaked in September, the beginning of college. Mean ratings of emotional intensity were high, mean ratings of surprise and life impact were below the moderate level and substantial numbers of memories had never been recounted previously. The proportion of memories that focused on specific episodes rather than on general experiences decreased as the number of years since graduation increased. The incidence of specific memories also declined as a function of memory order: Memories reported first were more likely to be specific than memories reported later. The results suggest that transitional and emotional episodes are especially likely to persist in memory for many years. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychological predictors of good health in three longitudinal samples of educated midlife women.

Concurrent and longitudinal associations between cognitive and affective personality variables—intellectual efficiency (IE), anxiety, and hostility—and observer ratings of physical health were examined in 3 longitudinal samples of women: Mills Longitudinal Study (n?=?101); Radcliffe Study (RS, n?=?118); and University of California, San Francisco Study (n?=?44). Observer ratings of health were based on participants' reports of health problems. The California Psychological Inventory (H. G. Gough, 1996) IE, Hostility, and Anxiety Scales were used in all studies at Times 1 and 2, except in RS, when at Time 1 the Zung Anxiety (W. K. Zung, 1971) and the Profile of Mood States (D. M. McNair, M. Lorr, & L. F. Droppleman, 1971) Hostility Scales were used. In the majority of analyses, EE was positively associated with good health, and Anxiety and Hostility were negatively associated with health. IE was the strongest independent predictor of health, indicating that cognitive characteristics may have an important role in health and should be examined further. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Household bottled water consumption in Phoenix: a lifestyle choice

The demand for bottled water has grown tremendously in recent years, together with concern about its environmental impacts. The authors surveyed individuals in Phoenix, Arizona about their water consumption behaviour, socio-demographic characteristics, perception of water quality and trust in the government's willingness to respond to water quality issues. Using a logit model, the authors then tested the relationship between the respondents' characteristics and bottled water consumption for cooking and drinking in the home. Our results indicate that bottled water consumption reflects lifestyle choice not environmental concerns.     

A User‐based Visual Analytics Workflow for Exploratory Model Analysis

Many visual analytics systems allow users to interact with machine learning models towards the goals of data exploration and insight generation on a given dataset. However, in some situations, insights may be less important than the production of an accurate predictive model for future use. In that case, users are more interested in generating of diverse and robust predictive models, verifying their performance on holdout data, and selecting the most suitable model for their usage scenario. In this paper, we consider the concept of Exploratory Model Analysis (EMA), which is defined as the process of discovering and selecting relevant models that can be used to make predictions on a data source. We delineate the differences between EMA and the well‐known term exploratory data analysis in terms of the desired outcome of the analytic process: insights into the data or a set of deployable models. The contributions of this work are a visual analytics system workflow for EMA, a user study, and two use cases validating the effectiveness of the workflow. We found that our system workflow enabled users to generate complex models, to assess them for various qualities, and to select the most relevant model for their task.