β-Cyclodextrin Inclusion Complex to Improve Physicochemical Properties of Pipemidic Acid: Characterization and Bioactivity Evaluation

The aptitude of cyclodextrins (CDs) to form host-guest complexes has prompted an increase in the development of new drug formulations. In this study, the inclusion complexes of pipemidic acid (HPPA), a therapeutic agent for urinary tract infections, with native β-CD were prepared in solid state by kneading method and confirmed by FT-IR and ¹H NMR. The inclusion complex formation was also characterized in aqueous solution at different pH via UV-Vis titration and phase solubility studies obtaining the stability constant. The 1:1 stoichiometry was established by a Job plot and the inclusion mechanism was clarified using docking experiments. Finally, the antibacterial activity of HPPA and its inclusion complex was tested on P. aeruginosa, E. coli and S. aureus to determine the respective EC_50s and EC_90s. The results showed that the antibacterial activity of HPPA:β-CD against E. coli and S. aureus is higher than that of HPPA. Furthermore, HPPA and HPPA:β-CD, tested on human hepatoblastoma HepG2 and MCF-7 cell lines by MTT assay, exhibited, for the first time, antitumor activities, and the complex revealed a higher activity than that of HPPA. The use of β-CD allows an increase in the aqueous solubility of the drug, its bioavailability and then its bioactivity.     

Compensation of birefringence in lead‐free polarizing beam splitters for LCOS projectors

Abstract— Most optical designs for delivering light to LCOS imagers and then from the imagers to the projection lens use polarizing‐beam‐splitter (PBS) technology. Most of the PBSs used in commercial LCOS projectors contain glass with a significant amount of lead (Pb). Such glasses have inherently low stress birefringence, and therefore maintain the polarization state of light passing through them. However, Pb‐bearing glass is an expensive, difficult to process, and hazardous material with special disposal requirements and is therefore not desirable in consumer‐electronic products. On the other hand, Pb‐free wire‐grid plate PBSs require a longer back focal length than would be optimal. Data and modeling results show that uniform high‐contrast dark states may be obtained from lead‐free‐glass Cartesian PBS prisms when a quarter‐wave compensator is used between the imager and the PBS.     

3D simulation as training tool in container terminals: The TRAINPORTS simulator

Modeling & Simulation (M&S) provides one of the best solutions for personnel and managers training in complex environments. In this article, the authors present an advanced High Level Architecture (HLA) federation of simulators (TRAINPORTS, TRAINing in marine PORTs by using Simulation), that recreates in a three-dimensional virtual environment the most important transshipment terminal of the South Mediterranean area, the Gioia Tauro container terminal. The TRAINPORTS federation includes four different federates (Straddle Carrier, Quay Crane, Forklift and Truck) and offers an advanced tool for marine port operators’ training providing the sensation of being in a real container terminal environment. The TRAINPORTS federation is part of an innovative family of simulators (called ST_VP, Simulation Team Virtual Port). This article presents the TRAINPORTS architecture, describes the federates/federation development process and discusses the simulators operation modes and verification and validation issues.     

Prospects for the use of high-Tc superconductors in fusion magnets and options for their test in SULTAN

In the last few years, the critical current densities of long commercially available REBa₂Cu₃O_7?x (RE-123, where RE represents Y or a rare earth element) coated conductors have reached values of 250 A/cm-width at 77 K and zero applied field. Even higher values of 600 A/cm-w (77 K, B = 0) have been demonstrated in shorter lengths. The attractive features of the use of these high-T_c superconductors (HTS) are operation temperatures above 20 K and/or magnetic fields higher than those envisaged for the ITER TF coils. Possible operation conditions for HTS fusion magnets have been studied taking into consideration the possible further improvements of RE-123 coated conductors. Investigations of stability and quench behavior indicate that stability is not a problem, whereas quench detection and protection need attention. Because of the high currents necessary for fusion magnets, many tapes need to be assembled into a transposed conductor. The qualification of HTS conductors for fusion magnets would require their test at magnetic fields of 11 T and currents well above 10 kA. The possibilities to test straight HTS conductor samples in SULTAN have been considered. For a test at 4.5 K, only the development of a low resistance joint between the HTS conductor under test and the NbTi transformer of SULTAN would be necessary. Tests up to 20 K would require that the HTS sample is connected with the NbTi transformer by a conduction-cooled HTS bus bar of large thermal resistance similar to the HTS module of a current lead. HTS conductor tests at temperatures around 50 K would be possible with modified cryogenics.     

Two data structures for building tetrahedralizations

A polyhedral decomposition can be unambiguously described as the collection of four primitive elements (i.e., polyhedra, facets, edges, and vertices) plus their mutual adjacency relations. We consider here the problem of representing a specific kind of polyhedral decomposition, i.e., a tetrahedralization. We describe two different representations for a tetrahedralization. The first one can only model polyhedral decompositions with tetrahedral cells, while the second one is suitable for describing any partition of a volume into polyhedral cells with triangular facets. We present two sets of primitive Euler operators, which build and manipulate such representations while maintaining their topological integrity. The use of such operators is demonstrated in connection with two algorithms for building a Delaunay tetrahedralization, which show the different hedralization, which show the different uses of the two representations.     

On the non-linear Maxwell–Cattaneo equation with non-constant diffusivity: Shock and discontinuity waves

A numerical study on a non-linear hyperbolic diffusion equation is proposed. The Hartree hybrid method combining finite difference techniques with the method of characteristics is used in the presence of discontinuities between initial and boundary conditions. The technique proved to be an useful tool to overcome oscillation problems and spurious solutions in case of strong non-linearities related to both attractive or repulsive interactions between diffusing species. Two different expressions for the diffusion coefficient are used in order to compare our results with the ones obtained in previous studies relying upon the Laplace transform technique and the MacCormack predictor–corrector method. Finally, an analytic approach based on the singular surface theory is proposed to motivate the numerical results and to clarify some controversial aspects concerning the penetration depth of a diffusive front in the presence of interactions.     

Path‐following algorithms and experiments for an unmanned surface vehicle

This paper addresses the problem of path following in two‐dimensional space for underactuated unmanned surface vehicles (USVs), defining a set of guidance laws at the kinematic level. The proposed nonlinear Lyapunov‐based control law yields convergence of the path‐following error coordinates to zero. Furthermore, the introduction of a virtual controlled degree of freedom for the target to be followed on the path removes singularity behaviors present in other guidance algorithms proposed in the literature. Some heuristic approaches are then proposed to face the problem of speed of advance adaptation based on path curvature measurement and steering action prediction. Finally a set of experimental results of all the proposed guidance laws, carried out with the Charlie USV, demonstrates the feasibility of the proposed approach and the performance improvements, in terms of precision in following the reference path and transient reduction, obtained by introducing speed adaptation heuristics. © 2009 Wiley Periodicals, Inc.