全文获取类型
收费全文 | 1014000篇 |
免费 | 76253篇 |
国内免费 | 8460篇 |
学科分类
医药卫生 | 1098713篇 |
出版年
2021年 | 10641篇 |
2019年 | 9095篇 |
2018年 | 12335篇 |
2017年 | 9851篇 |
2016年 | 10530篇 |
2015年 | 13090篇 |
2014年 | 17172篇 |
2013年 | 21880篇 |
2012年 | 30504篇 |
2011年 | 32491篇 |
2010年 | 19292篇 |
2009年 | 17780篇 |
2008年 | 29068篇 |
2007年 | 30043篇 |
2006年 | 31007篇 |
2005年 | 29988篇 |
2004年 | 27242篇 |
2003年 | 26225篇 |
2002年 | 25311篇 |
2001年 | 56540篇 |
2000年 | 58483篇 |
1999年 | 49008篇 |
1998年 | 12136篇 |
1997年 | 10796篇 |
1996年 | 10678篇 |
1995年 | 9923篇 |
1994年 | 9108篇 |
1993年 | 8115篇 |
1992年 | 36032篇 |
1991年 | 34393篇 |
1990年 | 33166篇 |
1989年 | 32258篇 |
1988年 | 29304篇 |
1987年 | 28504篇 |
1986年 | 26483篇 |
1985年 | 25299篇 |
1984年 | 17891篇 |
1983年 | 15161篇 |
1982年 | 7800篇 |
1979年 | 15777篇 |
1978年 | 10581篇 |
1977年 | 9025篇 |
1976年 | 7859篇 |
1975年 | 8616篇 |
1974年 | 10453篇 |
1973年 | 9849篇 |
1972年 | 9354篇 |
1971年 | 8847篇 |
1970年 | 8414篇 |
1969年 | 7916篇 |
排序方式: 共有10000条查询结果,搜索用时 250 毫秒
71.
72.
A case of bullous pemphigoid associated with psoriasis vulgaris showing Hailey–Hailey disease‐like histopathological changes in regenerated epidermis without genomic mutation in ATP2C1 or ATP2A2 gene 下载免费PDF全文
73.
异常毒性最初是一种确保复杂成分制剂生产工艺一致性及安全性的辅助检测手段,后来成为针对外源性毒性污染物的通用安全性检测项,曾在世界范围内被各国药典收载。由于该检测与药品质量、安全性之间的关联性受到质疑,各国药典逐渐在各论及通则中删除该检测项,目前仅《中国药典》保留异常毒性。由于该检测存在设定限值难以统一、给药体积及给药剂量不合理、结果易受干扰且缺乏明确的判定标准等试验原理及设计上的缺陷,导致其试验结果没有实际参考意义。基于对历史数据的回顾分析,国际监管机构及卫生组织对异常毒性有了更为科学的认知,并已逐渐形成统一的监管共识:严格的生产控制措施和有效的质量检测手段,比异常毒性检测更为重要;异常毒性检测结果或与产品质量及污染不具相关性;在异常毒性检查中使用大量动物不符合动物福利和“3R”原则。本文从科学角度试论异常毒性作为药品质量控制指标的合理性,并总结异常毒性修订的科学原则,希望能为我国监管机构、制药行业修订异常毒性相关内容提供思考角度。 相似文献
74.
F. Fruzzetti G. Palla A. Sbrana T. Simoncini M. R. Sessa 《Gynecological endocrinology》2020,36(10):938-940
AbstractObjective: To understand the origin of extremely high gonadotropin levels in a perimenopausal woman.Methods: A 52-year-old woman with a 2?months of amenorrhea followed spontaneous menstrual cycles recovery was referred to our outpatient clinic with elevated follicle-stimulating hormone (FSH, 483 mUI/ml), luteinizing hormone (LH, 475 mUI/ml) and prolactin (PRL, 173?ng/ml). She was known to take levosulpiride. The gonadotropin levels did not fit with the clinical features.Results: A gonadotroph tumor was ruled out. Further analysis confirmed constantly high FSH, LH and PRL levels. The measurements were repeated using different analytical platforms with different results. After serial dilutions, nonlinearity was present suggesting an immunoassay interference. After post-polyethylene glycol recovery, hormone levels appeared in the normal range. Anti-goat antibodies were recognized in the serum of the patient.Conclusions: This case report shows a case of falsely abnormal high gonadotropin and PRL levels in a woman during menopause transition. In the clinical practice the evaluation of gonadotropin profile is not recommended at this age, but the abnormal levels stimulated further evaluation. An interference in the assay due to anti-goat antibodies resulted in abnormally high level of FSH and LH. A strict collaboration between clinicians and the laboratory is needed, when laboratory findings do not correspond to clinical findings. 相似文献
75.
76.
77.
78.
T. Wu L. G. Trahair M. J. Bound C. F. Deacon M. Horowitz C. K. Rayner K. L. Jones 《Diabetic medicine》2015,32(5):595-600
79.
80.
Weiyu Ye Anna Olsson-Brown Robert A. Watson Vincent T. F. Cheung Robert D. Morgan Isar Nassiri Rosalin Cooper Chelsea A. Taylor Umair Akbani Oliver Brain Rubeta N. Matin Nicholas Coupe Mark R. Middleton Mark Coles Joseph J. Sacco Miranda J. Payne Benjamin P. Fairfax 《British journal of cancer》2021,124(10):1661
Background Immune checkpoint blockers (ICBs) activate CD8+ T cells, eliciting both anti-cancer activity and immune-related adverse events (irAEs). The relationship of irAEs with baseline parameters and clinical outcome is unclear.Methods Retrospective evaluation of irAEs on survival was performed across primary (N = 144) and secondary (N = 211) independent cohorts of patients with metastatic melanoma receiving single agent (pembrolizumab/nivolumab—sICB) or combination (nivolumab and ipilimumab—cICB) checkpoint blockade. RNA from pre-treatment and post-treatment CD8+ T cells was sequenced and differential gene expression according to irAE development assessed.Results 58.3% of patients developed early irAEs and this was associated with longer progression-free (PFS) and overall survival (OS) across both cohorts (log-rank test, OS: P < 0.0001). Median survival for patients without irAEs was 16.6 months (95% CI: 10.9–33.4) versus not-reached (P = 2.8 × 10−6). Pre-treatment monocyte and neutrophil counts, but not BMI, were additional predictors of clinical outcome. Differential expression of numerous gene pathway members was observed in CD8+ T cells according to irAE development, and patients not developing irAEs demonstrating upregulated CXCR1 pre- and post-treatment.Conclusions Early irAE development post-ICB is associated with favourable survival in MM. Development of irAEs is coupled to expression of numerous gene pathways, suggesting irAE development in-part reflects baseline immune activation.Subject terms: Immunotherapy, Melanoma 相似文献