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991.
Najet Rebai Guillermina Almazan Ling Wei Mark I. Greene H. Uri Saragovi 《The European journal of neuroscience》1996,8(2):273-281
A surface receptor complex of M r ˜65 000 (p65) and ˜95 000 (p95) is expressed in cells of the central nervous system of mice. This receptor is recognized by monoclonal antibody 87.92.6 or by reovirus type 3 haemagglutinin as unnatural ligands. The p65/p95 receptor is expressed mostly in neural embryonic precursors undergoing proliferation, especially those in the S-G2 phase of the cell cycle. Receptor expression decreases progressively throughout embryogenesis to low but detectable levels in the adult brain. Biochemical characterization revealed that the neural p65/p95 receptor complex is indistinguishable from the p65/p95 receptor expressed in T cells, where receptor ligation leads to a mitogenic block. In neural and lymphoid tissues the p65/p95 receptor (or an associated protein) possesses a tyrosine kinase enzymatic activity. Receptor ligation in neural cells resulted in the rapid tyrosine phosphorylation of cellular proteins which are different from substrates phosphorylated in T cells. Differential substrate coupling to the receptor may account for differences in signal transduction and biology between neural cells and T cells. Further study of this receptor complex may help define important features of neural proliferation, differentiation and survival. 相似文献
992.
为探讨流式细胞术对涎腺腺样囊性癌的诊断和预后估计的价值,对41例腺样囊性癌行流式细胞术分析。结果,平均DNA指数为1.179,S期细胞比例为29.49%,细胞增殖指数为42.67%,均明显高于正常组织。异倍体检出率为70.73%。随着肿瘤的增大和恶性程度的增加,其异倍体率、DNA指数和S期细胞比例值也相应增加。流式细胞术为涎腺腺样囊性癌的病理诊断和确定恶性程度提供了有效的辅助诊断措施,但尚不能判断预后。 相似文献
993.
就米非司酮配伍采米前列醇序贯用药终止7周内早孕118例进行临床观察,发现完全流产率92.37%,不全流产率5.93%,持续妊娠率1.69%。临床证明该方法方便、安全有效、副作用极小,但个别孕妇产生不全流产,引起出血过多及出血时间延长。不全流产率有随孕妇年龄、孕龄、孕次增加而增加的趋势。 相似文献
994.
C3d及荷C3d免疫复合物的测定与意义 总被引:2,自引:0,他引:2
用抗人C3和抗人IgGγ球蛋白组分作固相反应物,建立了检测补体活化片段C3d及荷C3d-IC的ELISA法,并对临床各类疾病患者血清C3d和C3d-IC的水平进行了测定,结果表明:慢性肾炎,SLE,慢性乙肝及肺炎患者血清C3d总体水平均较对照组显著增高,分别有58.5%~72.2%的病人C3d含量高于正常上限(P〈0.01),且该类病人亦有较高的C3d-IC阳性检出率(肺炎患者例外)本项研究中,C 相似文献
995.
OBJECTIVE. We evaluate whether patient outcomes may be affected by possible errors in care at discharge as assessed by Peer Review Organizations (PROs). DATA SOURCES/STUDY SETTING. The three data sources for the study were (1) the generic screen results of a 3 percent random sample of Medicare beneficiaries age 65 years or older who were admitted to California hospitals between 1 July 1987 and 30 June 1988 (n = 20,136 patients); (2) the 1987 and 1988 California Medicare Provided Analysis and Review (MEDPAR) data files; and (3) the American Hospital Association (AHA) 1988 Annual Survey of Hospitals. STUDY DESIGN. Multivariate logistic regression analysis was used to evaluate the association between the results of generic discharge administered by the PROs and two patient outcomes: mortality and readmission within 30 days. The analysis was adjusted for other patient characteristics recorded on the uniform discharge abstract. PRINCIPAL FINDINGS. Four discharge screens indicated an increased risk of an adverse outcome-absence of documentation of discharge planning, elevated temperature, abnormal pulse, and unaddressed abnormal test results at discharge. The other three discharge screens examined-abnormal blood pressure, IV fluids or drugs, and wound drainage before discharge-were unrelated to postdischarge adverse outcomes. CONCLUSIONS. Generic discharge screens based on inadequate discharge planning, abnormal pulse, increased temperature, or unaddressed abnormal tests may be important indicators of substandard care. Other discharge screens apparently do not detect errors in care associated with major consequences for patients. 相似文献
996.
Injection of TFP (a specific antagonist of CaM) into the lateral ventricles of the rat brain on the fourth day of pregnancy causes marked antifertility effect in 83% of the rats (0% in the control group). Examination with the pontamone blue reaction for the implantation elucidated that the antifertitity effect was due to the blockage of implantation of the follicle. Injection of TFP into the lateral ventricles of the brain markedly reduced the concentration of CaM in hypothalamus, ovary and uterus. Serum progesterone was also reduced. However, injection glven on day 7 was ineffective to terminate the pregnancy. Injection given on certain time of pregnancy was able to reduce the cellular CaM content and to cause antifertitity. This finding demonstrated that CaM played an important rote during the course of pregnancy. 相似文献
997.
P53基因突变与宫颈癌关系的研究 总被引:1,自引:0,他引:1
目的:通过对宫颈癌P53基因7-8外显子突变的研究,探讨该基因的突变与宫颈癌的发生、发展之间的关系。方法:本文运用聚合酶链式反应(PCR)方法,对宫颈癌组织P53的7-8外显子是突变进行了试验,并与非肿瘤的慢性宫颈炎(宫颈糜烂、宫颈息肉)组织作了对照。结果:10例宫颈癌标本中有7例出现了P537-8外显子的突变,阳性率高;而8例作为对照的宫颈炎标本仅有1例出现可疑的阳性结果。结果:试验结果说明,宫 相似文献
998.
999.
目的 探讨可溶性白细胞介素 2受体 (sIL 2R)和可溶性白细胞介素 6受体 (sIL 6R)在多发性硬化(MS)发病过程中的作用。方法 采用双体夹心ELISA法对 2 9例MS急性期患者及 2 0例炎性神经病患者、39例非炎性神经病患者、2 0例健康对照者脑脊液和血清中sIL 2R和sIL 6R的含量进行检测。结果 MS患者血清和脑脊液中sIL 2R、sIL 6R含量明显高于非炎性神经病组 (P <0 .0 5 )及健康对照组 (P <0 .0 1) ;MS组sIL 2R和血清sIL 6R含量与炎性神经病组比较 ,无显著性差异 ,但脑脊液中sIL 6R水平明显低于炎性神经病组 (P <0 .0 1)。结论 sIL 2R和sIL 6R在MS急性期患者体内明显升高 ,进一步证实了MS有关免疫学的发病机制 ,并为临床诊断MS提供了具有参考价值的实验室指标 相似文献
1000.