全文获取类型
收费全文 | 3421篇 |
免费 | 133篇 |
国内免费 | 15篇 |
学科分类
医药卫生 | 3569篇 |
出版年
2023年 | 30篇 |
2022年 | 25篇 |
2021年 | 121篇 |
2020年 | 56篇 |
2019年 | 57篇 |
2018年 | 67篇 |
2017年 | 60篇 |
2016年 | 80篇 |
2015年 | 67篇 |
2014年 | 85篇 |
2013年 | 140篇 |
2012年 | 202篇 |
2011年 | 180篇 |
2010年 | 112篇 |
2009年 | 107篇 |
2008年 | 158篇 |
2007年 | 150篇 |
2006年 | 202篇 |
2005年 | 148篇 |
2004年 | 131篇 |
2003年 | 136篇 |
2002年 | 141篇 |
2001年 | 94篇 |
2000年 | 89篇 |
1999年 | 76篇 |
1998年 | 27篇 |
1997年 | 30篇 |
1996年 | 34篇 |
1995年 | 19篇 |
1994年 | 22篇 |
1993年 | 21篇 |
1992年 | 57篇 |
1991年 | 53篇 |
1990年 | 49篇 |
1989年 | 44篇 |
1988年 | 55篇 |
1987年 | 45篇 |
1986年 | 52篇 |
1985年 | 40篇 |
1984年 | 38篇 |
1983年 | 35篇 |
1982年 | 13篇 |
1981年 | 14篇 |
1979年 | 31篇 |
1978年 | 16篇 |
1977年 | 17篇 |
1976年 | 14篇 |
1972年 | 15篇 |
1969年 | 13篇 |
1968年 | 14篇 |
排序方式: 共有3569条查询结果,搜索用时 234 毫秒
61.
K. Tsukada T. Miyazaki H. Katoh N. Masuda M. Fukuchi R. Manda Y. Fukai M. Nakajima M. Sohda H. Kimura H. Kuwano 《Digestive and liver disease》2006,38(4):240-244
BACKGROUND: Perioperative steroid therapy is often used in oesophageal cancer surgery and we evaluate the effect of this therapy on the secretory leukocyte protease inhibitor levels in the lungs (a major antiprotease in the conducting airways) and postoperative course in oesophageal cancer patients. METHODS: Twenty-one patients operated on for oesophageal cancer in 2003-2004 were treated with perioperative steroid therapy (250 mg of methylprednisolone intravenously 1 h before the operation). Fifteen consecutive patients operated on in 2002 served as a control group. Secretory leukocyte protease inhibitor in bronchoalveolar lavage fluid and the postoperative course in the two groups were compared. RESULTS: The mortality rate was 0% and there was no significant difference in the morbidity rate between the two groups. Days of intubation and systemic inflammatory response syndrome were significantly shorter for the steroid group. The bronchoalveolar lavage fluid secretory leukocyte protease inhibitor level was significantly higher in the steroid group than in the control group on postoperative days 2 and 3. The secretory leukocyte protease inhibitor level on postoperative day 3 was remarkably lower for the patients intubated for > or = 5 days and for those with pulmonary complications. CONCLUSION: Perioperative steroid therapy increased the bronchoalveolar lavage fluid secretory leukocyte protease inhibitor level and reduced the days of intubation and systemic inflammatory response syndrome in patients with oesophagectomy. 相似文献
62.
Shuichi Miyakawa Shin Ishihara Tadahiro Takada Masaru Miyazaki Kazuhiro Tsukada Masato Nagino Satoshi Kondo Junji Furuse Hiroya Saito Toshio Tsuyuguchi Fumio Kimura Hideyuki Yoshitomi Satoshi Nozawa Masahiro Yoshida Keita Wada Hodaka Amano Fumihiko Miura 《Journal of hepato-biliary-pancreatic sciences》2008,15(1):7-14
No strategies for the diagnosis and treatment of biliary tract carcinoma have been clearly described. We developed flowcharts for the diagnosis and treatment of biliary tract carcinoma on the basis of the best clinical evidence. Risk factors for bile duct carcinoma are a dilated type of pancreaticobiliary maljunction (PBM) and primary sclerosing cholangitis. A nondilated type of PBM is a risk factor for gallbladder carcinoma. Symptoms that may indicate biliary tract carcinoma are jaundice and pain in the upper right area of the abdomen. The first step of diagnosis is to carry out blood biochemistry tests and ultrasonography (US) of the abdomen. The second step of diagnosis is to find the local extension of the carcinoma by means of computed tomography (CT), magnetic resonance imaging (MRI), magnetic resonance cholangiopancreatography (MRCP), percutaneous transhepatic cholangiography (PTC), and endoscopic retrograde cholangiopancreatography (ERCP). Because resection is the only way to completely cure biliary tract carcinoma, the indications for resection are determined first. In patients with resectable disease, the indications for biliary drainage or portal vein embolization (PVE) are checked. In those with nonresectable disease, biliary stenting, chemotherapy, radiotherapy, and/or best supportive care is selected. 相似文献
63.
Nakano K Okada Y Tanizawa T Kanda K Morita E Tsukada J Tanaka Y 《Clinical calcium》2001,11(12):1667-1669
64.
Hirota Tomoya McElroy Eoin So Ryuhei 《Journal of autism and developmental disorders》2021,51(8):2764-2772
Journal of Autism and Developmental Disorders - In the present study, we employed network analysis that conceptualizes internet addiction (IA) as a complex network of mutually influencing symptoms... 相似文献
65.
66.
Huan Li Yanan Wang Yutaro Aoki Saki Nishiyama Xiaofan Yang Tomoya Taguchi Akari Miura Ai Suzuki Lei Zhi Hidenori Goto Ritsuko Eguchi Takashi Kambe Yen-Fa Liao Hirofumi Ishii Yoshihiro Kubozono 《RSC advances》2020,10(45):26686
A superconducting KBi2 sample was successfully prepared using a liquid ammonia (NH3) technique. The temperature dependence of the magnetic susceptibility (M/H) showed a superconducting transition temperature (Tc) as high as 3.6 K. In addition, the shielding fraction at 2.0 K was evaluated to be 87%, i.e., a bulk superconductor was realized using the above method. The Tc value was the same as that reported for the KBi2 sample prepared using a high-temperature annealing method. An X-ray diffraction pattern measured based on the synchrotron X-ray radiation was analyzed using the Rietveld method, with a lattice constant, a, of 9.5010(1) Å under the space group of Fdm (face-centered cubic, no. 227). The lattice constant and space group found for the KBi2 sample using a liquid NH3 technique were the same as those reported for KBi2 through a high-temperature annealing method. Thus, the superconducting behavior and crystal structure of the KBi2 sample obtained in this study are almost the same as those for the KBi2 sample reported previously. Strictly speaking, the magnetic behavior of the superconductivity was different from that of a KBi2 sample reported previously, i.e., the KBi2 sample prepared using a liquid NH3 technique was a type-II like superconductor, contrary to that prepared using a high-temperature annealing method, the reason for which is fully discussed. These results indicate that the liquid NH3 technique is effective and simple for the preparation of a superconducting KBi2. In addition, the topological nature of the superconductivity for KBi2 was not confirmed.A superconducting KBi2 sample was successfully prepared using a liquid ammonia (NH3) technique. 相似文献
67.
Eisuke Suganuma Hideaki Sakata Nodoka Adachi Satoshi Asanuma Mihoko Furuichi Yoji Uejima Satoshi Sato Tomoya Abe Daigo Matsumoto Ryohei Takahashi Sachi Yamamoto Yutaka Kawano Takashi Arai Tsutomu Oh-ishi 《Journal of infection and chemotherapy》2021,27(2):185-191
ObjectivesValganciclovir (VGCV) has been shown to improve sensorineural hearing loss (SNHL) and neurological outcomes in patients with neonatal symptomatic congenital cytomegalovirus (cCMV) infection. However, reports on the pharmacokinetics, efficacy and safety of oral VGCV are limited. The aim of this study is to evaluate the pharmacokinetics of VGCV for use in the treatment of cCMV.MethodsThis was a single-center, retrospective observational study conducted at Saitama Children's Medical Center in Japan between 2012 and 2017. CMV DNA copy number, maximum plasma VGCV concentration (Cmax), and adverse events (ADEs) during treatment were evaluated.ResultsA total of 26 patients with cCMV who received VGCV were included in this study. The median age at VGCV initiation was 9.5 months (range 0–46). Twenty-one patients (81%) had SNHL at baseline. Of these, five patients (19%) presented with improved SNHL, and none experienced worsened SNHL during treatment. The mean VGCV Cmax was 3.5 μg/mL (range 2–5.3), with no significant variation among individual values, and the values were maintained during treatment. Furthermore, there were no correlations between the Cmax values and age, sex, SNHL improvement or ADEs. Neutropenia (<1000/mm3) was observed in six patients (23%); however, no serious ADEs occurred.ConclusionsVGCV prevented the progression of SNHL without serious ADEs due to its stable pharmacokinetics. This study provides safety and tolerability of VGCV for the treatment of cCMV patients. 相似文献
68.
Igarashi Y Mita T Mizuno R Watada H Tanaka Y Kawamori R Hirose T 《Endocrine journal》2005,52(6):683-689
In this retrospective longitudinal study, we focused on the clinical characteristics of Japanese individuals with recent onset impaired glucose tolerance (IGT) who have been followed up for insulin secretory function and 75-gram oral glucose tolerance test (OGTT) for more than 3 years annually before they progressed from normal glucose tolerance (NGT) to IGT. Subjects whose body weight did not show significant change for the period were selected and labeled as either NGT (no change in OGTT over 3 years) or IGT (progressors from NGT to IGT) groups (n = 24, each). We compared the basal biochemical data and response of plasma glucose and serum insulin after OGTT of the two groups. In the IGT progressors, significant increase of plasma glucose at 30 to 120 minutes during OGTT and significant decrease of HDL-cholesterol were observed since 3 years before onset of IGT. In addition to increase of serum glucose and decrease of HDL-cholesterol, serum insulin at 120 minutes during OGTT were significantly and remarkably high at onset and 3 years before onset of IGT. Plasma glucose at 30-120 minutes and serum insulin level at 120 minutes after glucose load are potentially significant predictors of progression from NGT to IGT even in subjects who do not show increase of body weight. 相似文献
69.
70.