Prognosis following first-time myocardial infarction in patients with psoriasis: a Danish nationwide cohort study

Abstract. Ahlehoff O, Gislason GH, Lindhardsen J, Olesen JB, Charlot M, Skov L, Torp‐Pedersen C, Hansen PR. (Copenhagen University Hospital Gentofte, Hellerup; Copenhagen University Hospital Roskilde, Roskilde, Denmark). Prognosis following first‐time myocardial infarction in patients with psoriasis: a Danish nationwide cohort study. J Intern Med 2011; 270 : 237–244. Objectives. The magnitude of cardiovascular risk associated with psoriasis has been debated and the prognostic impact of psoriasis following myocardial infarction (MI) is unknown. Therefore, we investigated the risk of mortality and adverse cardiovascular events in patients with psoriasis following first‐time MI. Design, setting and participants. Cohort study of the entire Danish population including all individuals who experienced first‐time MI during the period 2002–2006. Multivariable Cox regression models were used to assess the post‐MI prognostic impact of psoriasis. Main outcome measures. All‐cause mortality and a composite cardiovascular end‐point of recurrent MI, stroke and cardiovascular death. Results. A total of 462 patients with psoriasis and 48 935 controls (mean age 69.5 and 70.6 years, respectively) were identified with first‐time MI during the study period. The mean follow‐up was 19.5 months [standard deviation (SD) 16.5] for patients with psoriasis and 22 .0 months (SD 18.7) for those without psoriasis. Incidence rates (IRs) per 1000 patient‐years for all‐cause mortality were 119.4 [95% confidence interval (CI) 117.2–138.3] and 138.3 (95% CI 114.1–167.7) for patients without and with psoriasis, respectively, and the adjusted hazard ratio (HR) associated with psoriasis was 1.18 (95% CI 0.97–1.43). For the composite end‐point, the IRs were 149.7 (95% CI 147.1–152.4) and 185.6 (95% CI 155.8–221.0) for patients without and with psoriasis, respectively, with an HR of 1.26 (95% CI 1.04–1.54) for patients with psoriasis. Conclusion. This first study of the impact of psoriasis on prognosis after first‐time MI indicated a significantly impaired prognosis in patients with psoriasis. Further studies of this novel association are warranted.     

Metformin‐associated risk of acute dialysis in patients with type 2 diabetes: A nationwide cohort study

Recent guidelines governing anti‐diabetic medications increasingly advocate metformin as first‐line therapy in all patients with type 2 diabetes. However, metformin could be associated with increased risk of acute kidney injury (AKI), acute dialysis and lactate acidosis in marginal patients. In a retrospective nationwide cohort study, a total of 168 443 drug‐naïve patients with type 2 diabetes ≥50 years, initiating treatment with either metformin or sulphonyl in Denmark between 2000 and 2012 were included in this study (70.7% initiated treatment with metformin); calculation of 1‐year risk of acute dialysis was based on g‐standardization of cause‐specific Cox regression models for acute dialysis, end‐stage renal disease and death. One‐year risks of acute dialysis were 92.4 per 100 000 (95% CI, 67.1‐121.3) and 142.7 per 100 000 (95% CI, 118.3‐168.0) for sulphonylurea and metformin, respectively. The metformin‐associated 1‐year risk of acute dialysis was increased by 50.3 per 100 000 (95% CI, 7.9‐88.6), corresponding to a risk ratio of 1.53 (95% CI, 1.06‐2.23), and a number needed to harm of 1988, thus providing evidence of potential concerns pertaining to the increasing use of metformin.     

Chronic bronchitis in Icelandic males: prevalence, sleep disturbances and quality of life.

OBJECTIVE: To study the prevalence of chronic bronchitis in Iceland and some aspects of quality of life among those suffering from chronic bronchitis. DESIGN: Postal questionnaires. SETTING, SUBJECTS: All Icelandic males born in the years 1913 and 1943 who were alive on 1 November 1993. Altogether 1175 (69.7%) responded. MAIN OUTCOME MEASURES: Physical symptoms of chronic bronchitis, stress symptoms, symptoms of dyspnea and sleep disturbances. RESULTS: 7.1% of those 50 years old and 16.7% of those 80 years old and a history of daily sputum expectoration for at least 3 months during the preceding 2 years. These individuals with chronic bronchitis had a higher prevalence of other respiratory symptoms than did the others, such as "wheezing or whistling" (59.6% vs. 7.2%), and "awakened by breathlessness" (35.2% vs. 6.0%). Complaints of dyspnea were more common among those with symptoms of chronic bronchitis, e.g. "dyspnea when walking" (19.4% vs. 1.4%) and "stops walking because of dyspnea" (22% vs. 1.6%). They also complained more often of insomnia and daytime sleepiness and found themselves more stressed than those without chronic bronchitis. These symptoms were all more common among the 80-year-old men. CONCLUSION: Our study indicates that chronic bronchitis is a frequent illness among Icelandic males. Men with chronic bronchitis often have decreased quality of life, difficulties in moving and frequently sleep complaints.     

Comparison of different methods for measuring intra-abdominal pressure

OBJECTIVE: Intra-abdominal pressure (IAP) can be measured in different ways but is usually measured indirectly via the urinary bladder. The aim of the study was to: 1) compare urinary bladder pressure, femoral vein pressure, and inferior caval vein pressure with IAP at different levels of IAP; and 2) try to find an optimal amount of fluid to be instilled into the urinary bladder before measurement of the bladder pressure, and to compare changes in blood flow in the femoral vein with that in the caval vein at different pressure levels. DESIGN: Experimental study. SETTING: Animal research laboratory. SUBJECTS: Eight domestic swine of both sexes, weighing 30.6+/-2.9 kg (mean+/-SD). INTERVENTIONS: Catheters connected to pressure transducers were placed into the urinary bladder, the inferior caval vein, the femoral vein, and the superior caval vein. Transit time flow probes were placed around the inferior caval vein and the femoral vein. After a stabilizing period, the abdominal pressure was increased stepwise by instillation of Ringer's solution into the abdomen and then decreased. Thereafter, we instilled fluid into the bladder at an IAP of 8 mmHg and at 20 mmHg and measured the amount of fluid needed to elevate the intra-vesical pressure by 2 mmHg. RESULTS: The pressures recorded in the urinary bladder, the inferior caval vein, and the femoral vein reflected the pressure in the abdominal cavity very well. The fluid volume needed to increase the bladder pressure by 2 mmHg was significantly lower at 20 mmHg IAP than at 8 mmHg. Blood flow in the femoral vein and the inferior caval vein showed a similar pattern and decreased when the intra-abdominal pressure increased. CONCLUSIONS: In our porcine model, and increasing the IAP by means of instillation of Ringer's solution, a reliable estimation of the IAP was obtained by measuring the pressure in the urinary bladder, the femoral vein or the inferior caval vein. The IAP estimated indirectly as the urinary bladder pressure is affected by the amount of fluid in the bladder, which should not exceed 10-15 ml. The decrease in femoral vein blood flow reflects the changes in inferior caval vein flow during increased IAP.     

A giant unruptured aneurysm of the sinus of Valsalva together with ectasia of the left coronary artery

A sinus of Valsalva aneurysm is defined as a dilatation of the aortic sinuses, between the aortic valve annulus and the sinotubular junction. They are rare and most frequently involve the right coronary sinus. We report a case of an unruptured giant sinus of Valsalva aneurysm in a patient associated with ectasia of the left main stem and left anterior descending coronary artery. The patient was successfully treated with aortic root replacement using a biologic conduit.     

Prevalence and incidence of respiratory symptoms in relation to indoor dampness: the RHINE study

BACKGROUND: An association between indoor dampness and respiratory symptoms has been reported, but dampness as a risk factor for the onset or remission of respiratory symptoms and asthma is not well documented. METHOD: This follow up study included 16 190 subjects from Iceland, Norway, Sweden, Denmark, and Estonia who had participated in the European Community Respiratory Health Survey (ECRHS I). Eight years later the same subjects answered a postal questionnaire that included questions on respiratory symptoms and indicators of indoor dampness. RESULTS: Subjects living in damp housing (18%) had a significantly (p<0.001) higher prevalence of wheeze (19.1% v 26.0%), nocturnal breathlessness (4.4% v 8.4%), nocturnal cough (27.2% v 36.5%), productive cough (16.6% v 22.3%) and asthma (6.0% v 7.7%). These associations remained significant after adjusting for possible confounders. Indoor dampness was a risk factor for onset of respiratory symptoms but not for asthma onset in the longitudinal analysis (OR 1.13, 95% CI 0.92 to 1.40). Remission of nocturnal symptoms was less common in damp homes (OR 0.84, 95% CI 0.73 to 0.97). CONCLUSIONS: Subjects living in damp housing had a higher prevalence of respiratory symptoms and asthma. Onset of respiratory symptoms was more common and remission of nocturnal respiratory symptoms was less common in subjects living in damp housing.