全文获取类型
收费全文 | 37937篇 |
免费 | 2366篇 |
国内免费 | 280篇 |
学科分类
医药卫生 | 40583篇 |
出版年
2023年 | 352篇 |
2022年 | 360篇 |
2021年 | 1354篇 |
2020年 | 798篇 |
2019年 | 1113篇 |
2018年 | 1316篇 |
2017年 | 1048篇 |
2016年 | 1140篇 |
2015年 | 1238篇 |
2014年 | 1573篇 |
2013年 | 1924篇 |
2012年 | 3049篇 |
2011年 | 2943篇 |
2010年 | 1651篇 |
2009年 | 1491篇 |
2008年 | 2399篇 |
2007年 | 2523篇 |
2006年 | 2325篇 |
2005年 | 2122篇 |
2004年 | 1946篇 |
2003年 | 1767篇 |
2002年 | 1561篇 |
2001年 | 474篇 |
2000年 | 414篇 |
1999年 | 400篇 |
1998年 | 301篇 |
1997年 | 252篇 |
1996年 | 220篇 |
1995年 | 174篇 |
1994年 | 153篇 |
1993年 | 123篇 |
1992年 | 210篇 |
1991年 | 167篇 |
1990年 | 151篇 |
1989年 | 133篇 |
1988年 | 173篇 |
1987年 | 119篇 |
1986年 | 104篇 |
1985年 | 119篇 |
1984年 | 102篇 |
1983年 | 69篇 |
1982年 | 58篇 |
1981年 | 44篇 |
1979年 | 66篇 |
1978年 | 60篇 |
1977年 | 38篇 |
1975年 | 38篇 |
1974年 | 43篇 |
1973年 | 65篇 |
1972年 | 44篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
52.
Marco Vivarelli Alessandro Cucchetti Fabio Piscaglia Giuliano La Barba Luigi Bolondi Antonino Cavallari Antonio Daniele Pinna 《Liver transplantation》2005,11(5):497-503
To confirm recent observations about the relationship between immunosuppression and the recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT), we retrospectively analyzed 70 consecutive HCC patients who underwent LT and received cyclosporine (CsA)-based immunosuppression. CsA trough blood levels, measured with the same technique (fluorescence polarization immunoassay), were analyzed at different time points after transplantation. The exposure to the drug was calculated with the trapezoidal rule in each patient. CsA was associated with steroids in 26 patients and steroids and azathioprine in 44 patients. HCC recurred in 7 patients (10.0%). Different immunosuppressive schedules (CsA and steroids vs. CsA, steroids, and azathioprine) or the cumulative dosage of steroids and azathioprine did not influence HCC recurrence that was associated instead with CsA exposure (278.3 +/- 86.4 ng/mL in recurrent vs. 169.9 +/- 33.3 in tumor-free patients; P < 0.001); CsA exposure above 189.6 ng/mL was related to HCC recurrence at the receiver operating characteristic analysis (ROC). The relationship between CsA exposure; various clinical (sex, age, viral- vs. non-viral-related cirrhosis, preoperative vs. incidental diagnosis of HCC, alpha-fetoprotein [AFP] blood level), pathologic (pathologic tumor staging [pT] stage, presence of Milan criteria), and histologic (grading, presence of microvascular tumor invasion) parameters; and tumor recurrence were assessed. AFP (P = 0.032), microvascular tumor invasion (P = 0.044), and CsA exposure (P < 0.001) influenced recurrence-free survival at the univariate analysis; CsA exposure was the only independent prognostic determinant at multivariate analysis (P < 0.001). High CsA exposure favors tumor recurrence; CsA blood levels should be kept to the effective minimum in HCC patients. In the presence of pathologic and histologic risk factors, specific immunosuppressive protocols should be considered. 相似文献
53.
Current controversies in oral lichen planus: report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis. 总被引:11,自引:0,他引:11
Giovanni Lodi Crispian Scully Marco Carrozzo Mark Griffiths Philip B Sugerman Kobkan Thongprasom 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2005,100(1):40-51
Despite recent advances in understanding the immunopathogenesis of oral lichen planus (LP), the initial triggers of lesion formation and the essential pathogenic pathways are unknown. It is therefore not surprising that the clinical management of oral LP poses considerable difficulties to the dermatologist and the oral physician. A consensus meeting was held in France in March 2003 to discuss the most controversial aspects of oral LP. Part 1 of the meeting report focuses on (1) the relationship between oral LP and viral infection with special emphasis on hepatitis C virus (HCV), and (2) oral LP pathogenesis, in particular the immune mechanisms resulting in lymphocyte infiltration and keratinocyte apoptosis. Part 2 focuses on patient management and therapeutic approaches and includes discussion on malignant transformation of oral LP. 相似文献
54.
Roberto Marco 《Developmental dynamics》2006,235(4):855-860
In this review article, we shall focus our attention on the initial steps in the research career of José A. Campos-Ortega and the studies he undertook. Particular emphasis will be placed on how these early experiences shaped his personality and his future scientific contributions. 相似文献
55.
56.
57.
Greco E Litwicka K Ferrero S Baroni E Sapienza F Rienzi L Romano S Minasi MG Tesarik J 《Reproductive biomedicine online》2007,14(5):572-578
Italian legislation regarding reproductive medicine limits the number of embryos transferred per attempt to three. Thus, in order to achieve pregnancy, more IVF cycles may be required, generating a need for methods of ovarian stimulation with fewer side effects. The gonadotrophin-releasing hormone (GnRH) antagonists have several advantages in this respect, but there is a debate regarding a possible lower pregnancy rate from resulting cycles. This study evaluated the clinical applicability of GnRH antagonists for ovarian stimulation in young women undergoing intracytoplasmic sperm injection (ICSI) in which only three oocytes can be fertilized. The 200 women treated with GnRH antagonist had a significantly shorter stimulation and lower gonadotrophin consumption, oestradiol concentration, total and mature oocyte recovery as compared with 200 matched controls treated with GnRH agonist. No differences were found between the groups in the number of normal zygotes, total cleaved, transferred and high quality embryos, or in the clinical outcomes. Thus, the previously reported lower pregnancy rate in GnRH antagonist cycles may be related to the oocyte characteristics. Finally, under conditions of oocyte number restriction, the GnRH antagonist-based cycles may be proposed as an efficacious, safe and minimally invasive alternative to GnRH agonist in a standard long protocol. 相似文献
58.
Benedetti Panici P Manci N Bellati F Di Donato V Marchetti C Calcagno M Morano G Servodio C Muzii L Angioli R 《Journal of minimally invasive gynecology》2007,14(3):348-351
The Bartholin's gland cyst is a condition that occurs in approximately 2% of women, most of whom are of reproductive age. Although benign, it is associated with significant patient discomfort. Definitive treatment involves the surgical removal of the entire cyst. The objective of this study was to describe an alternative conservative surgical technique with CO(2) laser adopted in our institution and to evaluate the feasibility, complication rate, and results obtained with this technique in an office setting. Our study showed that CO(2) laser treatment of the Bartholin's gland cyst can be carried out safely in an outpatient setting, with minimum patient discomfort and high long-term cure rates. 相似文献
59.
60.
Papillary thyroid microcarcinomas (PTMs) are small tumors (< or =1 cm of diameter) that belong to the well-differentiated low-risk carcinomas of the thyroid, which are characterized by benign behavior, probably of little clinical significance, and do not affect patients' survival. They are found in otherwise normal thyroids or in multinodular goiters with a clinical frequency varying substantially according to different series. Sometimes, PTM may be associated with lymph node metastases at presentation and/or locoregional recurrences during follow-up. Distant metastases are extremely rare, but have been reported. Although deaths related to PTM are almost unknown, PTM raises therapeutic implications. This review addresses the issue of definition, treatment, and follow-up of PTM. 相似文献