全文获取类型
收费全文 | 760926篇 |
免费 | 52839篇 |
国内免费 | 1418篇 |
学科分类
医药卫生 | 815183篇 |
出版年
2021年 | 6834篇 |
2019年 | 6950篇 |
2018年 | 10296篇 |
2017年 | 7580篇 |
2016年 | 8166篇 |
2015年 | 8923篇 |
2014年 | 11829篇 |
2013年 | 17852篇 |
2012年 | 24828篇 |
2011年 | 26396篇 |
2010年 | 15017篇 |
2009年 | 13398篇 |
2008年 | 23742篇 |
2007年 | 25402篇 |
2006年 | 25393篇 |
2005年 | 23958篇 |
2004年 | 23204篇 |
2003年 | 22008篇 |
2002年 | 21272篇 |
2001年 | 37981篇 |
2000年 | 38932篇 |
1999年 | 31563篇 |
1998年 | 8198篇 |
1997年 | 6841篇 |
1996年 | 7153篇 |
1995年 | 6796篇 |
1994年 | 6225篇 |
1992年 | 23266篇 |
1991年 | 23168篇 |
1990年 | 22508篇 |
1989年 | 22248篇 |
1988年 | 20174篇 |
1987年 | 19566篇 |
1986年 | 18597篇 |
1985年 | 17421篇 |
1984年 | 12802篇 |
1983年 | 10832篇 |
1982年 | 5975篇 |
1979年 | 11548篇 |
1978年 | 8165篇 |
1977年 | 6852篇 |
1976年 | 6616篇 |
1975年 | 7308篇 |
1974年 | 8547篇 |
1973年 | 8179篇 |
1972年 | 7683篇 |
1971年 | 7166篇 |
1970年 | 6922篇 |
1969年 | 6340篇 |
1968年 | 5819篇 |
排序方式: 共有10000条查询结果,搜索用时 468 毫秒
101.
C. M. de Bont N. Eerden W. C. Boelens G. J. M. Pruijn 《Clinical and experimental immunology》2020,199(1):1-8
Neutrophils can form neutrophil extracellular traps (NETs) to capture microbes and facilitate their clearance. NETs consist of decondensed chromatin decorated with anti-microbial proteins. Here, we describe the effect of neutrophil proteases on the protein content of NETs. We show that the neutrophil serine proteases degrade several neutrophil proteins associated with NETs. Interestingly, the anti-bacterial proteins associated with NETs, such as myeloperoxidase, calgranulin B and neutrophil elastase (NE), seem to be less susceptible to proteolytic degradation than other NET proteins, such as actin and MNDA. NETs have been proposed to play a role in autoimmune reactions. Our data demonstrate that a large number of the autoepitopes of NET proteins that are recognized by autoantibodies produced by systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients are also removed by the proteases. In conclusion, neutrophil serine proteases have a major impact on the NET proteome and the proteolytic changes of NET-associated proteins may counteract autoimmune reactions to NET components. 相似文献
102.
Fast,sensitive and specific diagnosis of infections with Leishmania spp. in formalin‐fixed,paraffin‐embedded skin biopsies by cytochrome b polymerase chain reaction
下载免费PDF全文
![点击此处可从《The British journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
M. Gebhardt B. Ertas T.M. Falk N. Blödorn‐Schlicht D. Metze A. Böer‐Auer 《The British journal of dermatology》2015,173(5):1239-1249
103.
A. Hochsprung S. Escudero-Uribe A.J. Ibáñez-Vera G. Izquierdo-Ayuso 《Neurología (Barcelona, Spain)》2021,36(6):433-439
IntroductionPain is highly prevalent in patients with multiple sclerosis (MS); it is chronic in 50% of cases and is classified as nociceptive, neuropathic, or mixed-type. Pain affects quality of life, sleep, and the activities of daily living. Electrotherapy is an interesting alternative or complementary treatment in the management of pain in MS, with new innovations constantly appearing.Material and methodsThis study evaluates the effectiveness of treatment with monopolar dielectric transmission of pulsed electromagnetic fields (PEMF) for pain associated with MS. We performed a randomised, placebo-controlled clinical trial including 24 patients, who were assessed with the Brief Pain Inventory, the Multiple Sclerosis International Quality of Life questionnaire, the Beck Depression Inventory, and the Modified Fatigue Impact Scale.ResultsStatistically significant improvements were observed in maximum and mean pain scores, as well as in the impact of pain on work, personal relationships, and sleep and rest. Not significant differences were found between the treatment and placebo groups.ConclusionsTreatment with PEMF may be effective in reducing pain in patients with MS, although further research is necessary to confirm its effectiveness over placebo and to differentiate which type of pain may be more susceptible to this treatment. 相似文献
104.
Adilson Cunha Ferreira Edward Araujo Júnior Wellington P. Martins João Francisco Jordão Antônio Hélio Oliani Simon E. Meagher 《The journal of maternal-fetal & neonatal medicine》2015,28(14):1706-1710
Objective: To assess the quality of images and video clips of fetal central nervous (CNS) structures obtained by ultrasound and transmitted via tele-ultrasound from Brazil to Australia.Methods: In this cross-sectional study, 15 normal singleton pregnant women between 20 and 26 weeks were selected. Fetal CNS structures were obtained by images and video clips. The exams were transmitted in real-time using a broadband internet and an inexpensive video streaming device. Four blinded examiners evaluated the quality of the exams using the Likert scale. We calculated the mean, standard deviation, mean difference, and p values were obtained from paired t tests.Results: The quality of the original video clips was slightly better than that observed by the transmitted video clips; mean difference considering all observers = 0.23 points. In 47/60 comparisons (78.3%; 95% CI?=?66.4–86.9%) the quality of the video clips were judged to be the same. In 182/240 still images (75.8%; 95% CI?=?70.0–80.8%) the scores of transmitted image were considered the same as the original.Conclusion: We demonstrated that long distance tele-ultrasound transmission of fetal CNS structures using an inexpensive video streaming device provided images of subjective good quality. 相似文献
105.
106.
107.
108.
109.