腺苷对突触体^45Ca摄取的抑制作用

用同位素标记~(15)Ca法测定大鼠突触体内游离钙的浓度,探讨了腺苷对高钾、N-甲基-D-天冬氨酸(NMDA)谷氨酸(Glu)等刺激所致的Ca~(2 )内流增加的影响。结果发现腺苷在10nmol/L～0.1μmol/L范围内对高钾、NMDA、Glu等刺激所致的Ca~(2 )内流有抑制作用,并呈剂量依赖关系,最大抑制率分别为41.68±7.68％、31.32±6.17％、37.52±2.29％。这可能是腺苷对缺血性脑损伤保护作用的机理。     

鼻胆管引流灌注治疗急性胰腺炎的临床价值

目的　探讨鼻胆管引流灌注 (ENBD)治疗急性胰腺炎的临床价值。方法　 40例经B超或CT检查无胆总管、肝总管结石的急性胰腺炎患者随机分为ENBD治疗组和对照组 ,ENBD治疗组在常规逆行性胰胆管造影 (ERCP)检查时做胆汁常规检查及细菌培养 ,术后留置鼻胆管引流并交替应用 0 .9%氯化钠 5 0ml +庆大霉素 8万U 8h和 0 .5 %灭滴灵 5 0ml 8h灌注持续 3～ 5d ,对照组应用善宁 0 .1mg皮下注射 8h持续 3d并观察其 1年内的复发情况。结果　ENBD治疗组 2 0例患者胆汁中均发现有白细胞及黄、黑色泥沙样物 ,6例培养出微生物 ( 3 0 % ) ,ENBD治疗组与善宁治疗组的腹痛消失时间分别为 ( 8.45± 8.40 )h和 ( 3 8.10± 3 5 .43 )h(P =0 .0 0 2 ) ,血清淀粉酶恢复至正常所需时间分别为 ( 18.0 0± 8.2 6)h和 ( 5 6.40± 48.80 )h(P =0 .0 0 2 ) ,两组的 1年复发率分别为 5 %和 40 % ,其差异均有非常显著性 (P <0 .0 1)。结论　鼻胆管引流灌注治疗急性胰腺炎疗效确切而安全 ,能减少复发 ,胆汁淤积和感染在急性胰腺炎的发病中起重要作用。     

高等医学院校医学化学教材改革的几点思考

医学的发展已进入分子水平，医学生必须具有扎实的化学基础才能适应专业学习及临床、科研工作的需要。现行医学化学教材大多沿用几十年前的模式，部分内容陈旧滞后，实用性不强。面对现实，改革势在必行。我们认为，突出重点、注重实用、体现医学特色应作为改革的方向。     

血清可溶性白细胞介素2受体和T细胞亚群在单纯性肾病综合征患儿发病中作用的探讨

本文对26例儿童单纯性肾病综合征患者血清可溶性白细胞介素2受体（SIL-2R）及T细胞亚群进行研究。结果表明肾病活动期SIL-2R值升高（均值为895±245U／ml），CD_4~+／CD_8~+比值降低（P＜0.01），而肾病缓解期SIL-2R（均值为494±127U／ml）及CD_4~+／CD_8~+比值恢复正常，将SIL-2R值与CD_4~+／CD_8~+比值进行相关分析，发现两者呈负相关（r=-0.61，P＜0.05）。提示SIL-2R水平的升高及T细胞亚群的紊乱在儿童单纯性肾病发病机制中起到重要的作用。     

冷冻后人胚卵巢细胞团对hMG作用的内分泌与形态学反应

妊娠２０～２４周人胚胎卵巢经改进的超速冷冻仍具有内分泌功能。这种冷冻后的胚胎卵巢细胞团体外培养时，培养无数与细胞团的Ｅ２分泌能力呈负相关，形态学检查与此结果相吻合。冷冻后人胚胎卵巢的细胞团体外培养时培养位中人绝经期促性腺激素（ｈＭＧ）最适浓度为５０ＩＵ／Ｌ，培养的最适天数为１～３ｄ。这对人胚胎卵巢细胞团同种异体移植时受体促性腺激素水平内及培养时间的选择与设定有重要指导意义。     

川芎嗪和维拉帕米对缺血性急性肾衰初期保护效应的实验研究

１８只犬切除右肾，钳夹左肾动脉６０分的肾缺血模型，再灌注５小时。将动物随机分成对照组、川芎嗪组及维拉帕米组。观察尿量、菊糖清除率、利钠指数、平均动脉压及心率；再灌注５小时取肾组织作形态学检查。结果显示川芎嗪对肾功能及形态有保护作用，维拉帕米则无此作用，提示在手术中有肾缺血时以川芎嗪作为肾保护药物优于维拉帕米。     

氨基酸、有机酸、碱基核苷类化合物的双向色谱多相同步分析

30余种氨基酸、40余种非挥发性有机酸和20余种碱基核苷类化合物在一块薄层板上完成多相同步色谱分析；用紫外灯-吖啶试剂-镉茚三酮试剂实行组合显色定位分析。改善了尿液中非挥发性有机酸的溶剂萃取法，尿中三类化合物提取物的同步多相色谱分离效果良好。     

A retrospective analysis of the stability and relapse of soft and hard tissue change after bilateral sagittal split osteotomy for mandibular setback of 64 Taiwanese patients.

PURPOSE: This study was an analysis of the soft and hard tissue changes of the facial profile after bilateral sagittal splitting osteotomy for mandibular setback of Taiwanese patients. PATIENTS AND METHODS: We collected pre- and postsurgical lateral cephalographs of 64 patients (28 males, 36 females) with skeletal Class III malocclusion who received combined orthodontic-surgical treatment with bilateral sagittal splitting osteotomy mandibular setback at Taipei Veterans General Hospital between 1994 and 2000. Nineteen cephalometric parameters of (14 linear, 4 angular, and the BS index) soft and hard tissues were measured at 1 week before treatment, and 2 months and 1 year after surgery, and analyzed by paired t test. RESULTS: Mean patient age was 20.0 +/- 1.6 years. The patients underwent an average of 7 mm mandibular setback at the osseous pogonion (Pog). Average setbacks at Pog and soft tissue pogonion (pog) were 5.54 mm and 4.85 mm, respectively, at 1 year after surgery. The setback ratio of Pog/pog was 1:0.88. The hard tissue relapse at Pog was 21% at 1 year after surgery. Improvement in prognathic profile was demonstrated by significant changes in the positions of Pog and pog, ANB angle, the distance from lower lip to esthetic line (E-L lip), and the BS index after surgery. However, compared with parameters obtained from a normal Taiwanese population, the cephalometric data of Pog, pog, and BS index still indicated mild prognathism. CONCLUSION: Although mandibular prognathism could be grossly improved by bilateral sagittal splitting osteotomy mandibular setback, a significant amount of relapse occurred within 1 year after surgery. The extent of the postoperatively preserved features showing mandibular prognathism should be a concern for both patients and physicians.