全文获取类型
收费全文 | 2098820篇 |
免费 | 166043篇 |
国内免费 | 7335篇 |
学科分类
医药卫生 | 2272198篇 |
出版年
2018年 | 20526篇 |
2016年 | 18932篇 |
2015年 | 21311篇 |
2014年 | 29519篇 |
2013年 | 43938篇 |
2012年 | 55805篇 |
2011年 | 59441篇 |
2010年 | 36476篇 |
2009年 | 35459篇 |
2008年 | 56484篇 |
2007年 | 59960篇 |
2006年 | 61588篇 |
2005年 | 59477篇 |
2004年 | 56976篇 |
2003年 | 55314篇 |
2002年 | 53190篇 |
2001年 | 109155篇 |
2000年 | 112697篇 |
1999年 | 94119篇 |
1998年 | 25622篇 |
1997年 | 22638篇 |
1996年 | 23610篇 |
1995年 | 23168篇 |
1994年 | 21574篇 |
1993年 | 20104篇 |
1992年 | 75526篇 |
1991年 | 73073篇 |
1990年 | 70517篇 |
1989年 | 67832篇 |
1988年 | 62530篇 |
1987年 | 61170篇 |
1986年 | 57509篇 |
1985年 | 55400篇 |
1984年 | 41018篇 |
1983年 | 34669篇 |
1982年 | 20156篇 |
1981年 | 17848篇 |
1980年 | 16729篇 |
1979年 | 36722篇 |
1978年 | 25804篇 |
1977年 | 21900篇 |
1976年 | 19735篇 |
1975年 | 21028篇 |
1974年 | 24984篇 |
1973年 | 23795篇 |
1972年 | 22303篇 |
1971年 | 20753篇 |
1970年 | 19233篇 |
1969年 | 18025篇 |
1968年 | 16627篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
81.
82.
Moncef Khairallah Padmamalini Mahendradas Andre Curi Sana Khochtali Emmett T. Cunningham Jr. 《Ocular immunology and inflammation》2019,27(2):219-228
Purpose: To review the systemic and ocular manifestations of specific emergent viral infectious diseases relevant to the ophthalmologist with particular emphasis on anterior uveitisMethods: Review of literature.Results: Arboviral diseases are among the most important emergent and resurgent human infections, occurring mostly in tropical and subtropical zones, but appearing in virtually all regions of the world as a result of climate change, travel, and globalization. Arboviral infections are transmitted to humans by the bite of hematophagous arthropods, mainly mosquitoes. Systemic disease may range from asymptomatic to life-threatening. A wide variety of ocular manifestations, including uveitis, has been reported in association with these emerging viral diseases. Numerous viruses other than arboviruses also have been recently recognized as a potential cause of uveitis.Conclusions: Proper clinical diagnosis of any emerging infectious disease is based on epidemiological data, history, systemic symptoms and signs, and the pattern of ocular involvement. The diagnosis is usually confirmed by detection of virus-specific DNA or antivirus antibodies in serum. 相似文献
83.
84.
85.
86.
Recurrent Oral and Genital Ulcers in an Infant: Neonatal Presentation of Pediatric Behçet Disease 下载免费PDF全文
Emma F. Johnson M.D. Danielle M. Hawkins M.D. Laura K. Gifford M.D. Aimee C. Smidt M.D. 《Pediatric dermatology》2015,32(5):714-717
Behçet disease is a complex, multisystem disease characterized by recurrent oral and genital ulcerations. It rarely occurs in infants or children. Neonatal Behçet disease has been reported in infants whose ulcers resolve at or before 9 weeks of age. Few cases of neonatal Behçet disease persisting into childhood have previously been reported. We report the case of a 1‐month‐old infant who presented with severe recurrent genital ulcerations and at 6 months developed recurrent oral ulcerations. Her orogenital ulcerations continue to recur. Human leukocyte antigen testing revealed HLA‐B51 and B44 positivity. This is a case of pediatric Behçet disease in the neonatal period. Behçet disease should be considered in the differential diagnosis of recurrent genital and oral ulcerations in infants and children. 相似文献
87.
Dermoscopic difficult lesions: an objective evaluation of reflectance confocal microscopy impact for accurate diagnosis 下载免费PDF全文
88.
D. Baker G. Pryce L. K. James K. Schmierer G. Giovannoni 《European journal of neurology》2020,27(2):221-228
Clinical trials are probably the most informative experiments to help an understanding of multiple sclerosis (MS) biology. Recent successes with CD20‐depleting antibodies have focused attention towards B cell subsets as important mediators in MS. The trial of tabalumab (NTC00882999), which inhibits B cell activation factor (BAFF), is reported and reviewed and this trial is contrasted with the trial on the inhibition of a proliferation‐inducing ligand (APRIL) and BAFF using atacicept (NCT00642902). Both tabalumab and atacicept induce depletion of mature B cells and inhibit antibody formation, but they fail to deplete memory B cells and do not inhibit relapsing MS. Atacicept is reported to augment memory B cell responses and may precipitate relapse, suggesting the importance of APRIL. However, BAFF inhibition can enhance peripheral blood memory B cell responses, which was not associated with augmented relapse. Although other interpretations are possible, these data further support the hypothesis that memory B cells may be of central importance in relapsing MS, as they are the major CD20+ B cell subset expressing APRIL receptors. They also suggest that quantitative and/or qualitative differences in B cell responses or other factors, such as an immune‐regulatory effect associated with APRIL, may be important in determining whether MS reactivates following neutralization of peripheral B cell maturation and survival factors. 相似文献
89.
90.