Germinal center cell lymphomas: Prognostic significance of their histopathological differentiation

Summary Clinical data of 48 patients with centrocytic, 83 patients with centroblastic/centrocytic and 64 patients with centroblastic lymphoma who had entered a prospective multicenter study of the Kiel Lymphoma Study Group since October 1975 were compared. Advanced (stage IV) disease at time of diagnosis, predominantly due to bone marrow infiltration, was most frequent in centrocytic (69% of patients) and in centroblastic/centrocytic (51% of patients) lymphomas as compared to only 28% of patients with centroblastic lymphoma. High survival probability of patients with localized centrocytic and centroblastic/centrocytic lymphomas after radiotherapy, contrasting with a worse prognosis of corresponding patients with centroblastic lymphoma, is compatible with the classification of these lymphoma entities as neoplasias of low-grade malignancy. However, as shown by this prospective and previous retrospective trials overall survival probability of patients with advanced centrocytic lymphoma was inferior to that observed in corresponding patients with centroblastic/centrocytic lymphoma. These findings suggest the possibility that patients with advanced centrocytic lymphoma occupy an intermediate position between typical low-grade and typical high-grade malignant non-Hodgkin lymphomas.Supported by the Deutsche Krebshilfe e. V., BonnPresented in part at the 5th Meeting of the International Society of Haematology, European and African Division, Hamburg, August 26–31, 1979     

Efficacy of the subcutaneous reformulated triptorelin depot in children with central precocious puberty

The efficacy, safety and acceptance of newly formulated triptorelin s.c. (Decapeptyl^®     

Glucosetoleranz eutropher und dystropher Säuglinge nach intravenöser Glucoseinjektion

Zusammenfassung Die Glucosetoleranz 29 eutropher und 24 dystropher Säuglinge wurde nach intravenöser Injektion von 1 g Glucose pro Kilogramm Körpergewicht untersucht. Die Eliminationsrate der Glucose aus dem Blut ist auf Grund der Befunde bei eutrophen Säuglingen oft beträchtlich höher, als man sie in anderen Altersklassen findet. Sie unterscheidet sich bei dystrophen Säuglingen nicht signifikant von der eutropher Säuglinge.

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Summary The glucose tolerance following intravenous injection of glucose was studied in 24 malnourished infants in Germany using 29 well-nourished infants as a control group. The disappearance rate of glucose from the blood of the infants investigated is considerably higher than in other age classes. There is no difference in this respect between both groups.

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Mit Unterstützung durch die Deutsche Forschungsgemeinschaft.     

Flash visual evoked response binocular summation in normal subjects and in patients with early-onset esotropia before and after surgery

Flash visual evoked responses were recorded and visual evoked response binocular summation was assessed in normal children between the ages of 1 and 58 months, in normal adults and in children with early-onset esotropia before and longitudinally for 1 year after surgical binocular alignment. Normal flash visual evoked response binocular summation started in the range of facilitation (> 2.0) at 1 month of age and decreased to adult levels by 3.7 months of age. The shape of the flash visual evoked response binocular summation function obtained from the patients with early-onset esotropia, appeared similar to that of normal subjects; however, the rapid decrease in flash visual evoked response binocular summation from facilitation to normal adult levels occurred after surgical binocular alignment. In normal adults, flash visual evoked response binocular summation was significantlyreduced by a 40-diopter base-in prism, suggesting that binocular misalignment was not the reason for the facilitation in flash visual evoked response binocular summation in either childhood population. It is proposed that this facilitation may reflect a process that leads to binocularity and that develops rapidly with binocular alignment.     

Preferential binding of the epidermal growth factor receptor to ganglioside GM3 coated plates

Ganglioside GM3 has been shown to modulate epidermal growth factor receptor function. These observations have lead to the hypothesis that GM3 may bind to the epidermal growth factor receptor. An enzyme-linked immunosorbant assay was designed to test this hypothesis. In these experiments, receptor-rich vesicle preparations were incubated with ganglioside GM1 or GM3 coated 96-well microtiter plates and the amount of bound receptor was compared. Plates coated with GM3 consistently bound more epidermal growth factor receptor than did GM1 coated wells appeared to be specific and saturable. These results suggest that GM3 may modulate epidermal growth factor receptor function owing to a specific association of the two molecules.