117例肠外瘘的护理及临床分析

目的:探讨117例肠外瘘病人的护理体会.方法:选择117例肠外瘘的患者,将护理工作重点放在这些患者手术和非手术的观察和护理上,同时给予相应的护理.结果:本组病例经治疗后,治愈率达91.5％,经确定性手术治愈者60.7％,瘘愈合时间为15天～10个月,平均96天,平均治愈时间41天.结论:护士做好病人心理护理的同时具备高度的责任心,做好各项基础护理是治疗成功的有力保障.     

长QT间期综合征患者麻醉后突发尖端扭转型室速抢救成功1例

患者,女性,年龄45岁,体重60 kg,ASA分级Ⅱ级。因"月经量增多6个月,发现子宫肌瘤渐进性增大6个月"入院。既往病史：左下肢静脉血栓病史6个月,规律溶栓治疗,半月前停药。术前化验检查：ECG提示校正的QT间期(QTc) 491 ms,血红蛋白66 g/L。经输血治疗后血红蛋白达到84 g/L。拟在全麻下行开腹子宫...     

Influence of blastocysts morphological score on pregnancy outcomes in frozen-thawed blastocyst transfers: a retrospective study of 741 cycles

The influence of inner cell mass （ICM） and trophectoderm （TE） score on pregnancy out- comes in frozen-thawed blastocyst transfer cycles was analyzed. A retrospective analysis of 741 cycles of frozen-thawed blastosysts transfer was performed. All cycles were divided into four groups based on the number and morphological score of blastocysts： S-ICM B/TE B group （n=91）, the single blastocyst transfer oflCM B and TE B; D-ICM B/TE B group （n=579）, double blastocysts transfer oflCM B/TE B; D-1CM B/TE C group （n=35）, double blastocysts transfer of ICM B/TE C; and D-ICM C/TE B group （n=36）, double blastocysts transfer ofTE B/ICM C. The pregnancy outcomes were compared among the four groups. As compared with D-ICM B/TE C group, the clinical pregnancy rate, implantation rate and multiple pregnancy rate were increased in D-ICM B/TE B group （74.96% vs. 57.14%, 57.43% vs. 37.14%, and .48.62% vs. 25%, respectively, P〈0.05 for all）. Clinical pregnancy rate and implantation rate in D-ICM B/TE B group were also higher than in D-ICM C/TE B group （74.96% vs. 50%, and 57.43% vs. 33.33%, both P〈0.05）. Multivariable Logistic regression analysis indicated that ICM score was a better predictive parameter for clinical pregnancy （OR=3.05, CI 1.70-5.46, P〈0.001）, while the trophectoderm score was a better one for early abortion （OR=0.074, CI 0.03-0.19, P〈0.001）. Clinical pregnancy rate and multiple pregnancy rate in S-ICM B/TE B group were significantly lower than those in D-ICM B/TE B group （46.15% vs. 74.96%, and 2.38% vs. 48.62%, both P〈0.05）, but there was no si~,,niflcant difference in the implantation rate between the two groups. It was suggested that the higher score of ICM and TE may be indicative of the better pregnancy outcomes. The ICM score is a better predictor of clinical pregnancy than TE, while TE score is a better one in predicting early abortion. Sin- gle ICM B/TE B blastocyst transfer in frozen-thawed cycles can also get satisfactory pregnancy out- comes.     

急性中毒所致的昏迷

某种物质进入人体 ,通过生物或理化作用 ,损害组织器官 ,使其产生功能紊乱或器质性损害 ,称为中毒。中毒时某些毒物可直接或间接地作用于中枢神经系统 ,引起高级神经中枢过度抑制或脑实质损害 ,而导致严重的意识障碍 (昏迷 ) ,称为中毒性脑病。中毒性脑病是急性中毒的危险症状 ,如不及时抢救可危及病人生命。1　发病机制(1)毒物对中枢神经系统的直接作用如镇静催眠药物、抗精神病药、麻醉剂、有机磷农药、乙醇等中毒时 ,可直接抑制大脑皮质 ,产生意识障碍。严重者引起昏迷。(2 )毒物妨碍氧的摄取、运输、利用①毒物造成肺水肿 ,影响气体交换…     

血液净化疗法在急性中毒中的应用

自1955年Schriener首次报道用血液透析治疗一例大剂量阿司匹林中毒患者以来，许多血液净化疗法被先后尝试用来清除急性中毒患者体内的毒物，并取得了一定的临床疗效。尤其近年来有关临床毒理学，特别是毒物动力学的研究为血液净化疗法治疗急性中毒提供了科学的依据。因此血液净化技术已成为现代急性中毒救治的重要手段。     

东北雷公藤对肾小球肾炎治疗作用的实验研究

目的 :探讨东北雷公藤对阿霉素肾炎动物模型的治疗作用。方法 :肾炎大鼠经东北雷公藤灌胃 2 8d后 ,检测大鼠尿蛋白、肾组织匀浆中纤溶酶原激活物抑制剂 ( PAI- 1 )及血胆固醇、肝功、肾功变化。结果 :东北雷公藤具有降低肾炎大鼠尿蛋白及肾组织中 PAI- 1的作用。结论 :东北雷公藤对肾炎大鼠有明显的治疗作用     

清热解毒合剂质量标准研究

目的提高清热解毒合剂的质量标准。方法以TLC法对清热解毒合剂中的金银花、甘草、知母等中药进行定性鉴别,以HPLC法测定制剂中的黄芩苷和绿原酸的含量。结果处方中金银花、甘草、知母、黄芩和连翘的薄层色谱斑点清晰,分离较好,阴性对照无干扰。黄芩苷在12.06¹93.00μg·ml^-1范围内,峰面积与进样浓度呈良好线性关系（r=0.9949）,平均加样回收率为100.33%,RSD为1.36%（n=6）。绿原酸在6.76²16.4μg·ml^-1范围内,峰面积与进样浓度呈良好线性关系（r=0.9999）。平均加样回收率为100.99%,RSD为1.105%（n=6）。结论该方法简便、可靠、专属性强,可作为清热解毒合剂质量控制方法。