Discrepant social communications.

Observed 32 children (13–42 mo old) individually in the presence of their mothers. Eight messages systematically varied between the visual and auditory channels were given by the experimenter. Some messages asked S to approach; other messages asked S to stay away. Some were congruent and others discrepant across channels. Order of presentation was counterbalanced across Ss. All Ss approached the experimenter when he unambiguously invited them with a smiling face, affirmative head nods, manual beckoning, and a pleasant tone of voice, saying, "Come here." When the experimenter's request to approach or to stay away was on one channel only, that is, was either visual or auditory, about three-fourths of the Ss conformed to it, approaching or staying away as requested. When requests were discrepant across channels, behavior was more variable, but more Ss conformed to the auditory than to the visual message. The messages constitute a Guttman scale, a unidimensional and cumulative hierarchy based on the individual patterns of responses to them. (20 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Influence of the Cutting Speed on the Torque in Drilling

Russian Engineering Research - Abstract—The forces associated with drilling are considered. The influence of the cutting speed on the torque and cutting force is investigated for drills of...     

Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model

Therapeutic approaches providing effective medication for Alzheimer’s disease (AD) patients after disease onset are urgently needed. Previous studies in AD mouse models suggested that physical exercise or changed lifestyle can delay AD-related synaptic and memory dysfunctions when treatment started in juvenile animals long before onset of disease symptoms, while a pharmacological treatment that can reverse synaptic and memory deficits in AD mice was thus far not identified. Repurposing food and drug administration (FDA)-approved drugs for treatment of AD is a promising way to reduce the time to bring such medication into clinical practice. The sphingosine-1 phosphate analog fingolimod (FTY720) was approved recently for treatment of multiple sclerosis patients. Here, we addressed whether fingolimod rescues AD-related synaptic deficits and memory dysfunction in an amyloid precursor protein/presenilin-1 (APP/PS1) AD mouse model when medication starts after onset of symptoms (at five months). Male mice received intraperitoneal injections of fingolimod for one to two months starting at five to six months. This treatment rescued spine density as well as long-term potentiation in hippocampal cornu ammonis-1 (CA1) pyramidal neurons, that were both impaired in untreated APP/PS1 animals at six to seven months of age. Immunohistochemical analysis with markers of microgliosis (ionized calcium-binding adapter molecule 1; Iba1) and astrogliosis (glial fibrillary acid protein; GFAP) revealed that our fingolimod treatment regime strongly down regulated neuroinflammation in the hippocampus and neocortex of this AD model. These effects were accompanied by a moderate reduction of Aβ accumulation in hippocampus and neocortex. Our results suggest that fingolimod, when applied after onset of disease symptoms in an APP/PS1 mouse model, rescues synaptic pathology that is believed to underlie memory deficits in AD mice, and that this beneficial effect is mediated via anti-neuroinflammatory actions of the drug on microglia and astrocytes.     

Synthesis of the Antibiotic Precursor Thiazolyl‐7‐Aminocephalosporanic Acid in a Microstructured Flow System

The synthesis of thiazolyl‐7‐aminocephalosporanic acid, a pharmaceutical precursor of the β‐lactam antibiotic drug cefodizime, could be successfully realized in a continuous microstructured flow system. This was accomplished by changing the process window from batch, having a reaction temperature of 60 °C with a reaction time of 1 h, to a flow system at temperatures > 100 °C and reaction times of several minutes. The space‐time yield could be increased by a factor of 130.     

From Facebook to the Neighbourhood: Infrastructuring of Hybrid Community Engagement

In recent years, social media have increased the resources that individuals and organizations are able to mobilize for the development of socially innovative practices. In this article, we engage with a naturally occurring development in a Trentinian neighbourhood to examine the cooperative interactions amongst members of a local community. The first author and local residents of the neighbourhood participated in online discussions, decision making, and physical activities that led to material changes in the area. The interventions are motivated by and based on the concept of Social Street that combines online interactions in a closed Facebook group with face-to-face meetings seeking to practically engage the collective in accomplishing certain immediate or ongoing needs. Over the course of two years, we studied this local instantiation of Social Street in Trento, Italy by way of an action-oriented (digital) ethnography. Through this work, we demonstrate how urban neighbourhoods might benefit from hybrid forms of community engagement that are enacted through a constant back and forth between online and face-to-face interactions. We further argue that the infrastructuring of local urban collectives should follow strategies that pay attention to the multiple issues in urban neighbourhoods and people’s attachments to them. Overall, the paper reflects upon the challenges and configurations of participation that this form of community-work entails.     

用于PEMFC的丙烷自热重整制氢操作条件优化研究

Autothermal reforming （ATR） is one of the leading methods for hydrogen production from hydrocarbons. Liquefied petroleum gas, with propane as the main component, is a promising fuel for on-board hydrogen producing systems in fuel cell vehicles and for domestic fuel cell power generation devices. In this article, propane ATR process is studied and operation conditions are optimized with PRO/Ⅱ from SIMSCI for proton exchange membrane fuel cell application. In the ATR system including water gas shift and preferential oxidation, heat in the hot streams and cold streams is controlled to be in balance. Different operation conditions are studied and drawn in contour plots. The region for ATR reforming with the highest efficiency can thus be identified. One operation point was chosen with the following process parameters： feed temperature for the ATR reactor is 425℃, steam to carbon ratio S/C is 2.08, air stoichiometry is 0.256. Thermal efficiency for the integrated system is calculated to be as high as 84.0 % with 38.27 % H2 and 3.2μl·L^-1 CO in the product gas.     

Self-assembled iron oxide nanoparticle multilayer: x-ray and polarized neutron reflectivity

We have investigated the structure and magnetism of self-assembled, 20 nm diameter iron oxide nanoparticles covered by an oleic acid shell for scrutinizing their structural and magnetic correlations. The nanoparticles were spin-coated on an Si substrate as a single monolayer and as a stack of 5 ML forming a multilayer. X-ray scattering (reflectivity and grazing incidence small-angle scattering) confirms high in-plane hexagonal correlation and a good layering property of the nanoparticles. Using polarized neutron reflectivity we have also determined the long range magnetic correlations parallel and perpendicular to the layers in addition to the structural ones. In a field of 5 kOe we determine a magnetization value of about 80% of the saturation value. At remanence the global magnetization is close to zero. However, polarized neutron reflectivity reveals the existence of regions in which magnetic moments of nanoparticles are well aligned, while losing order over longer distances. These findings confirm that in the nanoparticle assembly the magnetic dipole-dipole interaction is rather strong, dominating the collective magnetic properties at room temperature.     

Beurteilung von Korrosionsschutzsystemen für Offshore‐Windenergietürme – Teil 1: Problemstellung und Versuchsdurchführung

Assessment of corrosion protection systems for offshore wind energy towers – part 1: Introduction and test scenario. Based on field and on laboratory tests, the corrosion protective performance of different corrosion protection systems for offshore wind energy towers was investigated. The systems under investigation included duplex systems with Zn/Al metallization, multi‐layered organic systems, a single‐layer thick organic system, Zn/Mg metallization and cathodic protection of uncoated sections. Special field specimens and laboratory specimens were utilized in order to investigate the systems. Laboratory tests included immersion tests, ageing tests, test on cathodic compatibility and electro‐chemical impedance spectroscopy. Part 1 of the paper covers the general experimental design and details of the experimental procedures, whereas Part 2 deals with the results of the test programme.     

A mutation in the COX5 gene of the yeast Scheffersomyces stipitis alters utilization of amino acids as carbon source, ethanol formation and activity of cyanide insensitive respiration

Scheffersomyces stipitis PJH was mutagenized by random integrative mutagenesis and the integrants were screened for lacking the ability to grow with glutamate as sole carbon source. One of the two isolated mutants was damaged in the COX5 gene, which encodes a subunit of the cytochrome c oxidase. BLAST searches in the genome of Sc. stipitis revealed that only one singular COX5 gene exists in Sc. stipitis, in contrast to Saccharomyces cerevisiae, where two homologous genes are present. Mutant cells had lost the ability to grow with the amino acids glutamate, proline or aspartate and other non-fermentable carbon sources, such as acetic acid and ethanol, as sole carbon sources. Biomass formation of the mutant cells in medium containing glucose or xylose as carbon source was lower compared with the wild-type cells. However, yields and specific ethanol formation of the mutant were much higher, especially under conditions of higher aeration. The mutant cells lacked both cytochrome c oxidase activity and cyanide-sensitive respiration, whereas ADH and PDC activities were distinctly enhanced. SHAM-sensitive respiration was obviously essential for the fermentative metabolism, because SHAM completely abolished growth of the mutant cells with both glucose or xylose as carbon source.