全文获取类型
收费全文 | 2203篇 |
免费 | 131篇 |
国内免费 | 4篇 |
学科分类
工业技术 | 2338篇 |
出版年
2024年 | 7篇 |
2023年 | 29篇 |
2022年 | 21篇 |
2021年 | 64篇 |
2020年 | 51篇 |
2019年 | 69篇 |
2018年 | 75篇 |
2017年 | 63篇 |
2016年 | 92篇 |
2015年 | 74篇 |
2014年 | 107篇 |
2013年 | 170篇 |
2012年 | 127篇 |
2011年 | 172篇 |
2010年 | 144篇 |
2009年 | 101篇 |
2008年 | 131篇 |
2007年 | 113篇 |
2006年 | 119篇 |
2005年 | 100篇 |
2004年 | 74篇 |
2003年 | 79篇 |
2002年 | 55篇 |
2001年 | 43篇 |
2000年 | 33篇 |
1999年 | 27篇 |
1998年 | 25篇 |
1997年 | 14篇 |
1996年 | 27篇 |
1995年 | 18篇 |
1994年 | 14篇 |
1993年 | 11篇 |
1992年 | 12篇 |
1991年 | 11篇 |
1990年 | 8篇 |
1989年 | 13篇 |
1988年 | 10篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1980年 | 5篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有2338条查询结果,搜索用时 15 毫秒
91.
92.
Kritika Sharma Tim U. Krohne Volker Busskamp 《International journal of molecular sciences》2020,21(22)
Retinal degenerative diseases lead to irreversible blindness. Decades of research into the cellular and molecular mechanisms of retinal diseases, using either animal models or human cell-derived 2D systems, facilitated the development of several therapeutic interventions. Recently, human stem cell-derived 3D retinal organoids have been developed. These self-organizing 3D organ systems have shown to recapitulate the in vivo human retinogenesis resulting in morphological and functionally similar retinal cell types in vitro. In less than a decade, retinal organoids have assisted in modeling several retinal diseases that were rather difficult to mimic in rodent models. Retinal organoids are also considered as a photoreceptor source for cell transplantation therapies to counteract blindness. Here, we highlight the development and field’s improvements of retinal organoids and discuss their application aspects as human disease models, pharmaceutical testbeds, and cell sources for transplantations. 相似文献
93.
Dongqing Wang Mao Chen Yang Jiang Shuai Wang Zhixing Zhao Tim Evans Baojun Zhao 《Journal of the American Ceramic Society》2020,103(12):7299-7309
Phase equilibria and liquidus temperatures in the CaO–SiO2–Al2O3–MgO system at a CaO/SiO2 weight ratio of 0.9 in the liquid phase have been experimentally determined employing high-temperature equilibration and quenching technique followed by electron probe X-ray microanalysis. Isotherms at 1573, 1623, 1673, and 1773 K were determined and the primary phase fields of wollastonite, melilite, olivine, periclase, spinel, and corundum have been located. Compositions of the olivine and melilite solid solutions were analyzed and discussed. Comparisons between the newly constructed diagram, existing data, and FactSage predicted phase diagrams were performed and differences were discussed. The present study will be useful for guidance of industrial practices and further development of thermodynamic modeling. 相似文献
94.
95.
Stephanie Ehlers Dr. Daiane Szczerbowski Dr. Tim Harig Dr. Matthew Stell Dr. Susan Hötling Dr. Kathy Darragh Prof. Dr. Chris D. Jiggins Prof. Dr. Stefan Schulz 《Chembiochem : a European journal of chemical biology》2021,22(23):3300-3313
The butterfly Heliconius erato occurs in various mimetic morphs. The male clasper scent gland releases an anti-aphrodisiac pheromone and additionally contains a complex mixture of up to 350 components, varying between individuals. In 114 samples of five different mimicry groups and their hybrids 750 different compounds were detected by gas chromatography/mass spectrometry (GC/MS). Many unknown components occurred, which were identified using their mass spectra, gas chromatography/infrared spectroscopy (GC/IR)-analyses, derivatization, and synthesis. Key compounds proved to be various esters of 3-oxohexan-1-ol and (Z)-3-hexen-1-ol with (S)-2,3-dihydrofarnesoic acid, accompanied by a large variety of other esters with longer terpene acids, fatty acids, and various alcohols. In addition, linear terpenes with up to seven uniformly connected isoprene units occur, e. g. farnesylfarnesol. A large number of the compounds have not been reported before from nature. Discriminant analyses of principal components of the gland contents showed that the iridescent mimicry group differs strongly from the other, mostly also separated, mimicry groups. Comparison with data from other species indicated that Heliconius recruits different biosynthetic pathways in a species-specific manner for semiochemical formation. 相似文献
96.
Yüksel Korkmaz Behrus Puladi Kerstin Galler Peer W. Kmmerer Agnes Schrder Lina Glz Tim Sparwasser Wilhelm Bloch Andreas Friebe James Deschner 《International journal of molecular sciences》2021,22(2)
Nitric oxide (NO) binds to soluble guanylyl cyclase (sGC), activates it in a reduced oxidized heme iron state, and generates cyclic Guanosine Monophosphate (cGMP), which results in vasodilatation and inhibition of osteoclast activity. In inflammation, sGC is oxidized and becomes insensitive to NO. NO- and heme-independent activation of sGC requires protein expression of the α1- and β1-subunits. Inflammation of the periodontium induces the resorption of cementum by cementoclasts and the resorption of the alveolar bone by osteoclasts, which can lead to tooth loss. As the presence of sGC in cementoclasts is unknown, we investigated the α1- and β1-subunits of sGC in cementoclasts of healthy and inflamed human periodontium using double immunostaining for CD68 and cathepsin K and compared the findings with those of osteoclasts from the same sections. In comparison to cementoclasts in the healthy periodontium, cementoclasts under inflammatory conditions showed a decreased staining intensity for both α1- and β1-subunits of sGC, indicating reduced protein expression of these subunits. Therefore, pharmacological activation of sGC in inflamed periodontal tissues in an NO- and heme-independent manner could be considered as a new treatment strategy to inhibit cementum resorption. 相似文献
97.
98.
99.
The handling of dispersed solids may lead to undesirable release of dust particles. Size and quantity of the particles transferred into the gas with time depend on the binding and separating forces in the powder. These in turn are determined by characteristic parameters of the powder and of the process. Analogous to the well‐known “fractional collection efficiency” describing the dust separation, a newly defined “fractional release rate” to quantify the release of dust is introduced. The application is demonstrated by an example and the way to further development of this innovative approach is demonstrated. 相似文献
100.
In this paper, we focus on a critical aspect of work in organizations: using information in work tasks which is provided by information systems (IS) such as enterprise content management (ECM) systems. Our study based on the IS success model, 34 interviews, and an empirical study of 247 ECM system users at a financial service provider indicates that it is appropriate to differentiate between contextual and representational information quality as two information quality dimensions. Furthermore, we reveal that in addition to system quality, the two information quality dimensions are important in determining end-user satisfaction, which in turn influences the manifestation of workarounds. Our study also finds that employees using workarounds to avoid an ECM system implemented several years is negatively related to individual net benefits of the ECM system. Hence, we conclude that when investigating large-scale IS such as ECM systems, it is important to differentiate among information quality dimensions to more deeply understand end-user satisfaction and the resulting manifestation of workarounds. Moreover, this research guides organizations in implementing the most appropriate countermeasures based on the importance of either contextual or representational information quality. 相似文献