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Thérèse Sergent Jessica VanderstraetenJulie Winand Pauline BeguinYves-Jacques Schneider 《Food chemistry》2012
One strategy to prevent obesity could consist in the inhibition of the pancreatic lipase (PL). In an attempt to find natural antiobesity agents, phenolic compounds (PCs) and plant extracts were investigated on PL activity. Epigallocatechin-3-gallate > kaempferol and quercetin were detected as potent PL inhibitors, with ICs50 of 0.8, 13.4 and 21.5 μM, respectively. Plant extracts from green tea and grape seed also shown potent inhibitory effect. Selected PCs were then assayed in an in vitro model of simulated intestinal fat digestion, based on the lipolysis of triolein. In such conditions closer to physiological reality, resveratrol, but also epigallocatechin-3-gallate and quercetin reduced the triolein digestion to ±50%. This could delay or decrease in vivo fatty acid absorption by enterocytes. This work therefore suggests that some PCs, at concentrations easily reached in the intestine following ingestion of tea beverages, fruits or vegetables, but also flavonoid-enriched supplements or functional food, are potential candidates for obesity prevention. 相似文献
84.
Pauline E. Key Paul M. Finglas Nick Coldham Nigel Botting Mark F. Oldfield Roger Wood 《Food chemistry》2006
This quality assurance (proficiency testing) scheme was commissioned to enable the Food Standards Agency (FSA) to determine the quality of analytical results submitted by researchers measuring the concentrations of phytoestrogens in foods and biological fluids in FSA-funded research projects, and also, to demonstrate that FSA-funded laboratories are producing consistent and precise results. Non-FSA-funded laboratories from around the world were also invited to join in the scheme to increase the number participants. A secondary objective was to highlight the most successful methodologies used to analyse phytoestrogens. 相似文献
85.
This paper deals with the analytically tractable solution for input torques minimisation of two degrees of freedom serial manipulators based on minimum energy control and optimal redistribution of movable masses. The minimisation problem is carried out in two steps: at first, the optimal trajectory of the manipulator is defined as a function, which leads to the minimisation of energy consumption. Then, by introducing the obtained trajectory into dynamic equations, the torques are reduced by using the optimal redistribution of movable masses, which is carried out via an adaptive counterweight system. For this purpose, the torques due to the dynamic loads of the counterweights are presented as a function of the counterweight positions. The conditions for optimal dynamic balancing are formulated by minimisation of the root-mean-square value of the input torque including the dynamic loads of the unbalanced manipulator and counterweights. The suggested approach is illustrated by numerical simulations carried out using ADAMS software. 相似文献
86.
Stewart R Thom G Levens M Güler-Gane G Holgate R Rudd PM Webster C Jermutus L Lund J 《Protein engineering, design & selection : PEDS》2011,24(9):671-678
Ribosome display was applied to the Fc region of human immunoglobulin G (IgG1) to select for improved binding to human FcγRIIIa, the receptor expressed on human natural killer cells that mediates antibody-dependent cellular cytotoxicity (ADCC). A library of human Fcγ1 variants was generated using error-prone polymerase chain reaction, and subjected to multiple rounds of ribosome display selection against progressively decreasing concentrations of soluble human FcγRIIIa, to enrich for improved binders. Radioimmunoassay and alphascreen analyses of the aglycosylated IgG-Fc output revealed variants with improved binding to FcγRIIIa relative to wild-type IgG-Fc. Subsequent expression in human (HEK-EBNA) cells generated glycosylated IgGs with modified activity in ADCC assays. One particular variant, 125_B01 triggered enhanced ADCC (EC(50) up to four-fold reduced with increased maximal lysis) relative to wild-type antibody, having more equal levels of ADCC for each allotype (V158/F158) of FcγRIIIa. Deconvolution of individual replacements within the variant showed that improved function arose from the Phe243Leu replacement within the CH2 domain, rather than the CH3 domain replacements Thr393Ala or His433Pro. Surprisingly, the oligosaccharide profiles of 125_B01 indicated more oligosaccharide chains lacking fucose, or with bisecting N-acetylglucosamine relative to wild-type IgG1, which correlates with improved function and the replacement Phe243Leu that is a carbohydrate contact residue within the C(H)2 domain. 相似文献
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New statistics have revealed that the total number of plastic cards manufactured worldwide in 2002 hit 10.7 billion, just over 10% more than in 2001, when 9.7 billion cards were produced. This rise wasn’t reflected in the revenue picture, however, as extreme price pressure in 2002 meant that the market rose by just US$100 million from US$4.7 billion in 2001 to US$4.8 billion.Visit www.compseconline.com for the latest computer security industry news 相似文献
89.
Nina Pauline Holzapfel Boris Michael Holzapfel Simon Champ Jesper Feldthusen Judith Clements Dietmar Werner Hutmacher 《International journal of molecular sciences》2013,14(7):14620-14646
Lycopene is a phytochemical that belongs to a group of pigments known as carotenoids. It is red, lipophilic and naturally occurring in many fruits and vegetables, with tomatoes and tomato-based products containing the highest concentrations of bioavailable lycopene. Several epidemiological studies have linked increased lycopene consumption with decreased prostate cancer risk. These findings are supported by in vitro and in vivo experiments showing that lycopene not only enhances the antioxidant response of prostate cells, but that it is even able to inhibit proliferation, induce apoptosis and decrease the metastatic capacity of prostate cancer cells. However, there is still no clearly proven clinical evidence supporting the use of lycopene in the prevention or treatment of prostate cancer, due to the only limited number of published randomized clinical trials and the varying quality of existing studies. The scope of this article is to discuss the potential impact of lycopene on prostate cancer by giving an overview about its molecular mechanisms and clinical effects. 相似文献
90.
Kyriacos Zygourakis Hao Sun Pauline Markenscoff 《American Institute of Chemical Engineers》2013,59(9):3412-3420
The development of a novel nanoscale model that can accurately describe the reactivity of solids consisting of multiple components and having ordered and random pores is presented. Domains of multiple solid phases are distributed on a computational grid to simulate reactants with different specific reactivities and dispersions. Sub‐nanometer slit pores and larger cylindrical pores with given size distributions are also distributed on the grid in regular and random arrangements respectively. The generated solids are then eroded using rules that simulate a gas‐solid, non‐catalytic reaction occurring in the kinetic control regime. A parametric study is first carried out to demonstrate how key pore structural parameters affect the reactivity patterns. Model predictions are found to be in excellent agreement with experimental thermogravimetric data for the combustion of biochars, both when the slit and random cylindrical pores are fully accessible to the reactant and when diffusional limitations appear in the smaller slit pores. © 2013 American Institute of Chemical Engineers AIChE J, 59: 3412–3420, 2013 相似文献