Integrität und genetische Veränderung von Nutztieren

In discussing problems of genetic engineering animal ethicists frequently use the concept of animal integrity besides the concept of dignity. Integrity in general refers to the physical aspect of bodily intactness. But beyond that, the integrity of an animal comprises also a dynamic and an active-directed aspect. Within the framework of the integrity approach no fundamental difference can be found between genetic modification of farm animals by means of genetic engineering or selective breeding. Nevertheless genetic engineering is of particular importance for animal ethics because it evokes strong public reactions that may lead to a change in our attitude towards animals in our care. In the following text I will argue for this thesis using the example of genetic reduction of an animal’s essential capacities.     

Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors

The acid-sensing ion channels ASIC1 and ASIC2, as well as the transient receptor potential vanilloid channels TRPV1 and TRPV4, are proton-gated cation channels that can be activated by low extracellular pH (pH_e), which is a hallmark of the tumor microenvironment in solid tumors. However, the role of these channels in the development of skin tumors is still unclear. In this study, we investigated the expression profiles of ASIC1, ASIC2, TRPV1 and TRPV4 in malignant melanoma (MM), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and in nevus cell nevi (NCN). We conducted immunohistochemistry using paraffin-embedded tissue samples from patients and found that most skin tumors express ASIC1/2 and TRPV1/4. Striking results were that BCCs are often negative for ASIC2, while nearly all SCCs express this marker. Epidermal MM sometimes seem to lack ASIC1 in contrast to NCN. Dermal portions of MM show strong expression of TRPV1 more frequently than dermal NCN portions. Some NCN show a decreasing ASIC1/2 expression in deeper dermal tumor tissue, while MM seem to not lose ASIC1/2 in deeper dermal portions. ASIC1, ASIC2, TRPV1 and TRPV4 in skin tumors might be involved in tumor progression, thus being potential diagnostic and therapeutic targets.     

Evaluating π-π-Interactions as a Method for Isolation of Polycyclic Aromatic Hydrocarbons from Solution

The polycyclic aromatic hydrocarbon (PAH), chrysene, was linked to the solid support TentaGel S-NH₂ via a linker by means of synthesis. The resulting product 4-(chrysene-1-yloxy)-N-(TentaGel S)butanamide (4) was then evaluated for its ability to isolate PAHs from solution by means of π-π-interactions.     

Home Dissolution: What Happens After Separation?

Building a home and creating a family are highly interconnected processes. So what happens to the home when people separate or divorce? This paper addresses this question using both a quantitative and a qualitative approach. Based on an extensive database with socio-economic background data of 42 000 separated Danish couples in 2002, the housing careers of both partners were followed to see how the housing situation of different types of people was affected by the separation. In the qualitative approach, nine interviews with couples who had parted shed light on the emotions and practical problems of dissolving a home: how to decide who should stay? Who should move? What was it like to stay alone in, or to leave, the matrimonial home?     

Konservierungsmittel

Ohne Zusammenfassung     

The Energy Concept Adviser—A tool to improve energy efficiency in educational buildings

Educational buildings such as kindergartens, schools and universities display many similar design, operation and maintenance features in most countries. The two most noteworthy similarities amongst these building types are the high energy consumption and the necessity for retrofitting many buildings within this sector. However, studies have shown that during retrofit, energy saving measures are only rarely applied, because the decision-makers lack knowledge of investments and the efficiency of potential energy saving measures. The main goal of the International Energy Agency ECBCS Annex 36 is to provide the educational building decision-makers with sufficient data, information and tools to improve their learning and teaching environments by improving the energy efficiency of their buildings.     

Modeling the longitudinal variation of sawn timber grades in Norway spruce (Picea abies (L.) Karst.)

Grades derived from visual assessments of sawn timber are determined by the worst part of each piece. Since grade varies longitudinally in timber, grade yield will decrease if the average length of timber increases. The variation in grade is caused by longitudinal variation in knot properties and other features as they appear on the sawn surface taken into account during grading. The objective of this study is to describe and analyze this variation in Picea abies. The study consisting of 768 boards for which all features that could lead to downgrading were recorded noting position, type and size. Based on this information, all boards were graded according to appearance by Nordic Timber, and strength by INSTA 142. Logistic regression models of grade as a function of position in the stem were developed, and the dependence between responses was taken into consideration by using General Estimating Equations (GEE). The models showed a decreasing trend in grade from the butt end toward the top end of the trees, and the effect was more pronounced in strength grading than in appearance grading. Models with binomial response and different correlation structures were tested, and it was shown that both independent and autoregressive correlation structures could be used. This suggests that a multinomial ordinal logistic regression with a GEE-approach with an independent correlation structure is appropriate for modeling grade in this study.