During micromachining the accuracy of micro-feature is always a major concern. Using laser beam micro-milling (LBMM) the produced size is generally larger than the input design size. Another important drawback of LBMM is the formation of melt spatter around the feature geometry. The spatter adheres within the premises of the machined feature and influences the machining results, especially the geometry of previously machined features by adhering inside or around the feature. Determination of spatter size is very important when the objective is to produce an array of micro-features such as micro-channels. Thus, the minimum distance between two consecutive micro-features is necessary to be known in order to achieve safe geometry for which the size of spatter plays a significant role. The knowledge of spatter scattering and pre-calculated distance of dispersing spatter could certainly assist the machinist in estimating the safe distance between adjacent micro-channels. In this study, the micro-channel size and average spatter size are studied during the micro-milling of Ti-6AL-4V by Nd:YAG laser beam machining (LBM). Response surface methodology (RSM) has been utilized to plan a set of experiments and mathematical models are proposed to pre-calculate the channel size and spatter dispersion. Finally, the models are validated through confirmatory tests showing an acceptable range of error. 相似文献
Different flow regimes are known to occur in the interaction of multiphase gas–liquid flows over packed beds of solid particles, such as those observed in trickle bed reactors (TBRs). There are four major flow regimes that are known to occur in downward cocurrent flow in TBRs, namely: trickle, pulse, bubble, and mist flow regimes. In this work, the focus is on macro-scale experimental visualizations and investigations of the flow regimes in a two-dimensional TBR.
Experimental observations are made to investigate the development and transition of these flow regimes over a wide range of liquid and gas velocities. Cylindrical particles are placed between two glass plates that are sealed on the sides, and water and air are injected over them using an injection manifold to simulate multiphase flow in a TBR. A diffused light emitting device (LED) light table is used to illuminate the experimental window, while real time images are obtained using a high-speed camera. Flow maps are reported depicting all four regimes and the transition regions between them. Transition regions occur where the characteristics of more than one flow regime coexist.
The 2D experimental results are then compared with the existing literature data of three dimensional results and found to be in good agreement. Emphasis is placed on the transition between the trickle and pulse regimes, since that is the most important mode of operation in industrial TBRs. It is observed that the change in diameters of the cylindrical particles in a two-dimensional TBR has little effect on the transition between the flow regimes when the porosity of the bed is kept constant. 相似文献
A significant increase in the number of coronavirus cases can easily be noticed in most of the countries around the world. Inspite of the consistent preventive initiatives being taken to contain the spread of this virus, the unabated increase in the cases is both alarming and intriguing. The role of mathematical models in predicting and estimating the spread of the virus, and identifying various preventive factors dependencies has been found important and effective in most of the previous pandemics like Severe Acute Respiratory Syndrome (SARS) 2003. In this research work, authors have proposed the Susceptible-Infectected-Removed (SIR) model variation in order to forecast the pattern of coronavirus disease (COVID-19) spread for the upcoming eight weeks in perspective of Saudi Arabia. The study has been performed by using SIR model with a proposed simplification using average progression for further estimation of β and γ values for better curve fittings ratios. The predictive results of this study clearly show that under the current public health interventions, there will be an increase in the COVID-19 cases in Saudi Arabia in the next four weeks. Hence, a set of strong health primitives and precautionary measures are recommended in order to avoid and prevent the further spread of COVID-19 in Saudi Arabia. 相似文献
Bioethanol is considered the cleanest liquid fuel used as a substitute for depleting fossil fuels. Various technologies have been introduced to form bioethanol from lignocellulosic biomass. Seed pods of Bombax ceiba, which are produced and wasted in large amount annually, were used as a source of cellulose. In this study, response surface methodology was used to explore the effects of KOH concentrations, substrate loading, and residence time on cellulose exposure and liberation of reducing sugars (RS), total sugars (TS), and total phenolic compounds from seed pods of B. ceiba. Box–Behnken design with three variables and three levels showed maximum release of total phenolic compounds (394.04 mg/ml) and RS (50.06 mg/ml) corresponding to 3% KOH concentration, 15% substrate level with residence time of 8 h at 121°C, and maximum cellulose exposure (64%), and TS (206.65 mg/ml) liberation was observed at 5% KOH concentration and 10% substrate level at same temperature for same soaking time. While at room temperature maximum cellulose exposed (46%), TS (146.1480 mg/ml), total phenol (300.3901 mg/ml), and RS (9.0075 mg/ml) were observed at 3% KOH, 15% substrate concentration, and 8-h residence time. These results suggested that thermochemical pretreatment is more effective than chemical pretreatment alone. The second-order polynomial equation using analysis of variance was employed for analyzing the results. 相似文献
Paracetamol, a frequently used antipyretic and analgesic drug, has poor compression moldability owing to its low plasticity. In this study, new co-crystals of paracetamol (PCM) with caffeine (as a co-former) were prepared and delineated. Co-crystals exhibited improved compaction and mechanical behavior. A screening study was performed by utilizing a number of methods namely dry grinding, liquid assisted grinding (LAG), solvent evaporation (SE), and anti-solvent addition using various weight ratios of starting materials. LAG and SE were found successful in the screening study. Powders at 1:1 and 2:1 weight ratio of PCM/CAF by LAG and SE, respectively, resulted in the formation of co-crystals. Samples were characterized by PXRD, DSC, and ATR-FTIR techniques. Compressional properties of PCM and developed co-crystals were analyzed by in-die heckle model. Mean yield pressure (Py), an inverse measure of plasticity, obtained from the heckle plots decreased significantly (p?.05) for co-crystals than pure drug. Intrinsic dissolution profile of co-crystals showed up to 2.84-fold faster dissolution than PCM and physical mixtures in phosphate buffer pH 6.8 at 37?°C. In addition, co-crystals formulated into tablets by direct compression method showed better mechanical properties like hardness and tensile strength. In vitro dissolution studies on tablets also showed enhanced dissolution profiles (~90–97%) in comparison to the tablets of PCM prepared by direct compression (~55%) and wet granulation (~85%) methods. In a single dose sheep model study, co-crystals showed up to twofold increase in AUC and Cmax. A significant (p?.05) decrease in clearance as compared to pure drug was also recorded. In conclusion, new co-crystals of PCM were successfully prepared with improved tabletability in vitro and in vivo profile. Enhancement in AUC and Cmax of PCM by co-crystallization might suggest the dose reduction and avoidance of side effects. 相似文献
Building Simulation - Building-owned micro energy hubs (EHs) usually focus on optimal energy consumption cost and emission, whereas, macro energy hubs (MEHs) mainly concentrate on utility’s... 相似文献