Cholesterol content of human parotid saliva

Free and esterifed cholesterol were determined in parotid fluid collected from 19 individuals by encapsulation of Stenson's duct in the oral 16.7±7.1 (SD) μg/100 ml and cholesterol esters averaged 13.2±8.0 (SD) μg/100 ml. Two assays are described for the measurement of cholesterol in parotid saliva. Lipophilic material was extracted with ether-ethanol (3∶1). In assay 1, the solid residue of the extract was separated into its components by thin layer chromatography. Substances on the chromatogram were made to fluoresce and the spots were photographed. Cholesterol was determined by densitometry of its black image on film. In assay 2, the ether-ethanol residue was subjected to quantitative gas chromatography. Both methods yield similar data.     

High-Temperature Stiffness and Damping Measurements to Monitor the Glassy Intergranular Phase in Liquid-Phase-Sintered Silicon Carbides

Detailed stiffness and internal friction ( Q ⁻¹) versus temperature curves were obtained for liquid-phase-sintered silicon carbides using advanced resonant beam analysis up to 1400°C. As-sintered materials display a stable Q ⁻¹-peak near 1100°C, superimposed on an increasing background. The change of stiffness associated with the damping peak is quantitatively related to the amount of matter in pockets of the amorphous intergranular phase in which the refractory SiC matrix grains are embedded. The successful removal of the amorphous pockets by annealing at 1900°C is deduced from the disappearance of the damping peak and confirmed with transmission electron microscopy.     

Toughness Optimization of SBR Elastomers – Use of Fracture Mechanics Methods for Characterization

Elastomer materials are used in a wide application range and subjected to different loading from which failure of the material results. Because this failure is caused by initiation and propagation of cracks, the application of fracture mechanics methods for the assessment of the material is obvious. A short summary of the methods of technical fracture mechanics including possibilities of determination of crack resistance curves is given. Vulcanizates on the basis of SBR 1500 with various sulfur and carbon black contents were investigated. For describing the crack initiation and crack propagation behavior, several fracture mechanics examination methods were applied. Tear‐analyzer results were used to assess the crack propagation behavior under fatigue‐like loading conditions. Furthermore, for the characterization of the crack resistance of the materials under impact‐like loading conditions, instrumented tensile‐impact tests were performed. To obtain information about the initiation and propagation of a stable crack, quasi‐static fracture mechanics tests were applied. The results of the several tests are discussed in dependence on sulfur and carbon black contents. We found a non‐monotonous behavior of the toughness as a function of carbon black loading. An explanation is given in connection with a percolation‐like transition in filler morphology on larger length scales.

Schematic crack propagation curve for characterizing the fatigue behavior of the vulcanizates recorded in a TFA test.     

Polydimethylsiloxane based polyurethane and its composite with layered double hydroxide: Synthesis and its thermal properties

This investigation reports the synthesis of a new class of polyurethane (PU) based on bis(hydroxyalkyl) polydimethylsiloxane (PDMS) as diol and isophorone diisocyanate as diisocyanate followed by the preparation of PU/layered double hydroxide (PU/LDH) nanocomposite via ex-situ technique. Nuclear magnetic resonance and Fourier-transform infrared spectroscopy studies confirm the formation of PU and incorporation of PDMS into the PU backbone. Thermogravimetry analysis revealed that thermal stability of the composite improves significantly with incorporation of LDH into the PU matrix. This may be accredited to the barrier effect rendered by the LDH layers. Differential scanning calorimetry study reveals that with the incorporation of LDH, glass transition temperature (T_g) of the composite increases for an optimum level of loading beyond which it remains constant.     

Modeling culture in intelligent virtual agents

This work addresses the challenge of creating virtual agents that are able to portray culturally appropriate behavior when interacting with other agents or humans. Because culture influences how people perceive their social reality it is important to have agent models that explicitly consider social elements, such as existing relational factors. We addressed this necessity by integrating culture into a novel model for simulating human social behavior. With this model, we operationalized a particular dimension of culture—individualism versus collectivism—within the context of an interactive narrative scenario that is part of an agent-based tool for intercultural training. Using this scenario we conducted a cross-cultural study in which participants from a collectivistic country (Portugal) were compared with participants from an individualistic country (the Netherlands) in the way they perceived and interacted with agents whose behavior was either individualistic or collectivistic, according to the configuration of the proposed model. In the obtained results, Portuguese subjects rated the collectivistic agents more positively than the Dutch but both countries had a similarly positive opinion about the individualistic agents. This experiment sheds new light on how people from different countries differ when assessing the social appropriateness of virtual agents, while also raising new research questions on this matter.     

The nature and limits of violence

I take advantage of a point made by H. J. Gert, in "Rights and Rights Violators: A New Approach to the Nature of Rights" (The Journal of Philosophy 1990; 87 (12): 688-694) to provide the following definition of violence. "Violence is an intentional or knowing attempt by a moral agent to directly cause harm, i.e., death, pain, disability, loss of freedom or pleasure, to someone who is protected by morality without the consent of that person." I show how this definition applies to violence in hospitals and discuss some of the ethical problems created by violent patients.     

Forward dynamical analysis of flexible multibody systems using system-level model reduction

Fast simulation (e.g., real-time) of flexible multibody systems is typically restricted by the presence of both differential and algebraic equations in the model equations, and the number of degrees of freedom required to accurately model flexibility. Model reduction techniques can alleviate the problem, although the classically used body-level model reduction and general-purpose system-level techniques do not eliminate the algebraic equations and do not necessarily result in optimal dimension reduction. In this research, Global Modal Parametrization, a model reduction technique for flexible multibody systems is further developed to speed up simulation of flexible multibody systems. The reduction of the model is achieved by projection on a curvilinear subspace instead of the classically used fixed vector space, requiring significantly less degrees of freedom to represent the system dynamics with the same level of accuracy. The numerical experiment in this paper illustrates previously unexposed sources of approximation error: (1) the rigid body motion is computed in a forward dynamical analysis resulting in a small divergence of the rigid body motion, and (2) the errors resulting from the transformation from the modal degrees of freedom of the reduced model back to the original degrees of freedom. The effect of the configuration space discretization coarseness on the different approximation error sources is investigated. The trade-offs to be defined by the user to control these approximation errors are explained.     

In vivo interactive visualization of four-dimensional blood flow patterns

In this paper we give an overview over a series of experiments to visualize and measure flow fields in the human vascular system with respect to their diagnostic capabilities. The experiments utilize a selection of GPU-based sparse and dense flow visualization algorithms to show the diagnostic opportunities for volumetric cardiovascular phase contrast magnetic resonance imaging data sets. Besides classical hardware accelerated particle and line-based approaches, an extensible tublet-based visualization, a four-dimensional volumetric line integral convolution and a new two-dimensional cutting plane tool for three-dimensional velocity data sets have been implemented. To evaluate the results, several hearts of human subjects have been investigated and a flow phantom was built to artificially simulate distinctive flow features. Our results demonstrate that we are able to provide an interactive tool for cardiovascular diagnostics with complementary hardware accelerated visualizations. Electronic Supplementary Material  The online version of this article () contains supplementary material, which is available to authorized users.