In vivo Kinetic Biodistribution of Nano‐Sized Outer Membrane Vesicles Derived from Bacteria

Evaluation of kinetic distribution and behaviors of nanoparticles in vivo provides crucial clues into their roles in living organisms. Extracellular vesicles are evolutionary conserved nanoparticles, known to play important biological functions in intercellular, inter‐species, and inter‐kingdom communication. In this study, the first kinetic analysis of the biodistribution of outer membrane vesicles (OMVs)—bacterial extracellular vesicles—with immune‐modulatory functions is performed. OMVs, injected intraperitoneally, spread to the whole mouse body and accumulate in the liver, lung, spleen, and kidney within 3 h of administration. As an early systemic inflammation response, increased levels of TNF‐α and IL‐6 are observed in serum and bronchoalveolar lavage fluid. In addition, the number of leukocytes and platelets in the blood is decreased. OMVs and cytokine concentrations, as well as body temperature are gradually decreased 6 h after OMV injection, in concomitance with the formation of eye exudates, and of an increase in ICAM‐1 levels in the lung. Following OMV elimination, most of the inflammatory signs are reverted, 12 h post‐injection. However, leukocytes in bronchoalveolar lavage fluid are increased as a late reaction. Taken together, these results suggest that OMVs are effective mediators of long distance communication in vivo.     

生产过程质量不合格品系统(IQS)方案建模及优化

针对不合格品的高效处置、数据的有效分析对企业质量控制具有深远的意义,其是装备制造领域质量管理研究的重点。文章以SAP接口二次开发、IQS流程建模、数据库建立、系统实用价值等方面展开详细论述,确保质量信息可追溯分析。     

Precise Extraction of Charge Carrier Mobility for Organic Transistors

Unreliable mobility values, and particularly greatly overestimated values and severely distorted temperature dependences, have recently hampered the development of the organic transistor field. Given that organic field‐effect transistors (OFETs) have been routinely used to evaluate mobility, precise parameter extraction using the electrical properties of OFETs is thus of primary importance. This review examines the origins of the various mobilities that must be determined for OFET applications, the relevant extraction methods, and the data selection limitations, which help in avoiding conceptual errors during mobility extraction. For increased precision, the review also discusses device fabrication considerations, calibration of both the specific gate‐dielectric capacitance and the threshold voltage, the contact effects, and the bias and temperature dependences, which must actually be handled with great care but have mostly been overlooked to date. This review serves as a systematic overview of the OFET mobility extraction process to ensure high precision and will also aid in improving future research.     

南芬选矿厂中矿磨选系统改造实践

针对本钢南芬选矿厂中矿再磨选系统精矿铁品位波动较大的问题，进行了原因分析、改造方案研究与实践。改造后的实践表明：①通过将中矿再磨选系统的1段磁选机改造为孔宽009 mm的高频振动筛，铁精矿中磁铁矿的单体解离度提高了3.06个百分点，为后续磁选获得高品质铁精矿创造了条件。②优化后流程的精矿品位和回收率均得到有效提高，精矿铁品位达到了66.82%，较改造前提高了0.81个百分点，铁回收率提高了2.53个百分点。③回收率的提高以及前段球磨机处理能力的释放，年多产7.7万t精矿，可增加销售收入3 350万元/a，年多创利润6365万元。较好地达到了改造的目的。     

红岭矿18线南西翼通风系统技术改造

针对矿山18线南西翼矿体开采过程中存在的通风系统不完善、风量欠缺、污风无法及时排出等问题，运用风压平衡原理、网络优化技术、机站优化技术以及计算机网络模拟技术展开研究，拟定了3种可行的通风方案。经技术经济比较，确定了新掘18线905～855 m回风井（1.5 m），保留该井905 m 水平回风机站，并在855 m 水平新设1台K45 6 №12风机（18.5 kW）方案。数值模拟结果表明：18线南西翼通风系统总风量达到20.5 m3/s，井下风流的可调性和稳定性增强，为矿山的安全生产提供了有力保障。