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991.
Noor Azliza Wani Abd. Aziz Renu Agarwal Roqiah Fatmawati Abdul Kadir Azian Abd. Latiff Nafeeza Mohd Ismail 《Neurological research》2020,42(3):189-208
ABSTRACTObjective: Trans-resveratrol has been shown to have neuroprotective effects and could be a promising therapeutic agent in the treatment of intracerebral haemorrhage (ICH). This study aimed to investigate the involvement of the adenosine A1 receptor (A1R) in trans-resveratrol-induced neuroprotection in rats with collagenase-induced ICH.Methods: Sixty male Sprague–Dawley rats weighing 330–380 g were randomly divided into five groups (n = 12): (i) control, (ii) sham-operated rats, (iii) ICH rats pretreated with vehicle (0.1% DMSO saline, i.c.v.), (iv) ICH rats pretreated with trans-resveratrol (0.9 µg, i.c.v.) and (v) ICH rats pretreated with trans-resveratrol (0.9 µg) and the A1R antagonist, DPCPX (2.5 µg, i.c.v.). Thirty minutes after pretreatment, ICH was induced by intrastriatal injection of collagenase (0.04 U). Forty-eight hours after ICH, the rats were assessed using a variety of neurobehavioural tests. Subsequently, rats were sacrificed and brains were subjected to gross morphological examination of the haematoma area and histological examination of the damaged area.Results: Severe neurobehavioural deficits and haematoma with diffuse oedema were observed after intrastriatal collagenase injection. Pretreatment with trans-resveratrol partially restored general locomotor activity, muscle strength and coordination, which was accompanied with reduction of haematoma volume by 73.22% (P < 0.05) and damaged area by 60.77% (P < 0.05) in comparison to the vehicle-pretreated ICH group. The trans-resveratrol-induced improvement in neurobehavioural outcomes and morphological features of brain tissues was inhibited by DPCPX pretreatment.Conclusion: This study demonstrates that the A1R activation is possibly the mechanism underlying the trans-resveratrol-induced neurological and neurobehavioural protection in rats with ICH. 相似文献
992.
Pawan Gupta P. C. Khatri Renu Agarwal Pooja Gupta 《Indian journal of pediatrics》2012,79(11):1517-1519
The Caudal dysplasia syndrome (CDS) and the femoral hypoplasia-unusual facies syndrome (FHUFS) have been reported to be more frequent among infants of diabetic mothers (IDMs). Infact, uncontrolled maternal diabetes is the most common cause of both the syndromes. Till now, there is no case report to suggest absent radius as a manifestation of IDMs. The authors report a rare case of newborn, who presented with features compatible with both CDS and FHUFS with an additional feature of absent radius, which is not reported in the literature so far. The possibility that all these features represent different manifestations of the same disorder is discussed here. 相似文献
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Vasim Farooq Patrick W. Serruys Jung Ho Heo Bill D. Gogas Yoshinobu Onuma Laura E. Perkins Roberto Diletti Maria D. Radu Lorenz Räber Christos V. Bourantas Yaojun Zhang Eric van Remortel Ravindra Pawar Richard J. Rapoza Jennifer C. Powers Heleen M.M. van Beusekom Hector M. Garcìa-Garcìa Renu Virmani 《JACC: Cardiovascular Interventions》2013,6(5):523-532
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Anurag S. Rathore Mili Pathak Renu Jain Gaurav Pratap Singh Jadaun 《The AAPS journal》2016,18(4):793-800
Monitoring the quality of pharmaceutical products is a global challenge, heightened by the implications of letting subquality drugs come to the market on public safety. Regulatory agencies do their due diligence at the time of approval as per their prescribed regulations. However, product quality needs to be monitored post-approval as well to ensure patient safety throughout the product life cycle. This is particularly complicated for biotechnology-based therapeutics where seemingly minor changes in process and/or raw material attributes have been shown to have a significant effect on clinical safety and efficacy of the product. This article provides a perspective on the topic of monitoring the quality of biotech therapeutics. In the backdrop of challenges faced by the regulatory agencies, the potential use of multivariate data analysis as a tool for effective monitoring has been proposed. Case studies using data from several insulin biosimilars have been used to illustrate the key concepts. 相似文献
998.
Non‐invasive Assessment and Symptomatic Improvement of the Obstructed Nose (NASION): a physiology‐based patient‐centred approach to treatment selection and outcomes assessment in nasal obstruction 下载免费PDF全文
S.A.R. Nouraei J.S. Virk H. Kanona M. Zatonski E.F. Koury P. Chatrath 《Clinical otolaryngology》2016,41(4):327-340
999.
Ramandeep Kaur Virk Vithiagaran Gunalan Paul Anantharajah Tambyah 《Expert review of anti-infective therapy》2016,14(4):365-375
Influenza is a ubiquitous infection with a spectrum ranging from mild to severe. The mystery regarding such variability in the clinical spectrum has not been fully unravelled, although a role for the complex interplay among virus characteristics, host immune response and environmental factors has been suggested. Antivirals and current vaccines have a limited role in prophylaxis and treatment because they primarily target surface glycoproteins which undergo antigenic/genetic changes under host immune pressure. Targeting conserved internal proteins could lead the way to a universal vaccine which can be used against various types/subtypes. However, this is on the distant horizon, so in the meantime, developing improved vaccines should be given high priority. In this review, we discuss where the current influenza research stands in terms of vaccines, adjuvants, and how we can better predict the vaccine strains for upcoming influenza seasons by understanding complex phenomena which drive the continuous antigenic evolution. 相似文献
1000.
Sew Kim Low Soon Aun Tan Sarvarubini Nainee Glory Nancy Viapude Renu Kailsan 《Residential treatment for children & youth》2018,35(2):155-171
ABSTRACTFrequent reports concerning vandalism, bullying, and other delinquent behaviors have revealed that antisocial behaviors among adolescents are a major social issue in Malaysia. This study examined the relationships between poor parental monitoring, peer rejection, and antisocial behavior of Malaysian juvenile offenders. The participants consisted of three hundred and sixty (n = 360) juvenile offenders. Participants were selected randomly from three juvenile rehabilitation residential schools (Tunas Bakti Schools; TBS). The findings revealed a gender difference in antisocial behavior with a significant positive relationship between poor parental monitoring, peer rejection, and antisocial behavior. Parental monitoring was the strongest predictor of antisocial behavior among Malaysian juvenile offenders, followed by peer rejection. The result of the study reveals the importance of developing integrated preventive intervention programs focusing on positive parenting monitoring practices and the development of self-resilience among juvenile offenders 相似文献