全文获取类型
收费全文 | 4261篇 |
免费 | 203篇 |
国内免费 | 29篇 |
学科分类
医药卫生 | 4493篇 |
出版年
2024年 | 4篇 |
2023年 | 28篇 |
2022年 | 23篇 |
2021年 | 114篇 |
2020年 | 53篇 |
2019年 | 73篇 |
2018年 | 107篇 |
2017年 | 67篇 |
2016年 | 109篇 |
2015年 | 79篇 |
2014年 | 133篇 |
2013年 | 135篇 |
2012年 | 289篇 |
2011年 | 317篇 |
2010年 | 184篇 |
2009年 | 161篇 |
2008年 | 270篇 |
2007年 | 308篇 |
2006年 | 308篇 |
2005年 | 339篇 |
2004年 | 278篇 |
2003年 | 227篇 |
2002年 | 286篇 |
2001年 | 56篇 |
2000年 | 38篇 |
1999年 | 58篇 |
1998年 | 62篇 |
1997年 | 48篇 |
1996年 | 43篇 |
1995年 | 25篇 |
1994年 | 36篇 |
1993年 | 35篇 |
1992年 | 23篇 |
1991年 | 24篇 |
1990年 | 16篇 |
1989年 | 16篇 |
1988年 | 16篇 |
1987年 | 19篇 |
1986年 | 11篇 |
1985年 | 11篇 |
1984年 | 14篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 10篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1978年 | 6篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1965年 | 2篇 |
排序方式: 共有4493条查询结果,搜索用时 31 毫秒
91.
Inamochi Yuka Fueki Kenji Matsuyama Yusuke Yoshida-Kohno Eiko Fujiwara Takeo Wakabayashi Noriyuki 《Clinical oral investigations》2020,24(8):2603-2609
Clinical Oral Investigations - This study aimed to determine if oral dryness is associated with oral pain sensitivity in removable denture wearers. The pressure pain threshold (PPT) in the mucosa... 相似文献
92.
93.
94.
95.
Koizumi Noriyuki Hanamura Yukio Nishida Kazuya Mori Atsushi Watabe Keiji Takemura Takeshi Man Alias Kassim Faizul M. Morioka Shinsuke 《Conservation Genetics Resources》2015,7(1):133-135
Conservation Genetics Resources - We have developed microsatellite DNA markers for Mesopodopsis orientalis (Tattersall 1908), a widely distributed mysid crustacean in shallow waters of the coastal... 相似文献
96.
Clustered features of the metabolic syndrome and the risk for increased aortic pulse wave velocity in middle-aged Japanese men 总被引:11,自引:0,他引:11
The association between different features of the metabolic syndrome (MS) (obesity, hypertension, hypercholesterolemia, low high-density lipoprotein cholesterol level, hypertriglyceridemia, high fasting plasma glucose level, and hyperuricemia) and the risk for increased aortic pulse wave velocity (PWV) of > or = 8.0 m/sec was examined in 2431 Japanese men aged 35 to 54 years who were not taking antihypertensive medication. After controlling for age, cigarette smoking, and alcohol intake, the odds ratios for increased aortic PWV in subjects with 1, 2, 3, and > or = 4 features of the MS, compared with those without features of the MS, were 1.35 (95% CI, 0.86 to 2.11), 1.90 (95% CI, 1.18 to 3.06), 1.57 (95% CI, 0.89 to 2.76), and 2.38 (95% CI, 1.26 to 4.49), respectively (p for trend = 0.003). A 9-year longitudinal study was also performed to prospectively examine the association between clustered features of the MS and the development of increased aortic PWV in 2073 men without aortic stiffness with a PWV < 8.0 m/sec and without antihypertensive medication during the follow-up period. The multivariate-adjusted hazard ratios for the incidence of increased aortic PWV in subjects with 1, 2, 3, and > or = 4 features of the MS, compared with those without features of the MS, were 1.39 (95% CI, 1.10 to 1.77), 1.46 (95% CI, 1.1 1 to 1.92), 1.75 (95% CI, 1.27 to 2.40), and 2.22 (95% CI, 1.52 to 3.25), respectively (p for trend < 0.001). These results suggest that clustered features of the MS are closely associated with the risk for increased aortic PWV in middle-aged Japanese men. 相似文献
97.
Microsatellite instability in gallbladder carcinoma: two independent genetic pathways of gallbladder carcinogenesis 总被引:10,自引:0,他引:10
Yoshida T Sugai T Habano W Nakamura S Uesugi N Funato O Saito K 《Journal of gastroenterology》2000,35(10):768-774
Although the genetic basis for gallbladder carcinogenesis has not been clarified, considerable evidence has shown that genetic
alterations play an important role in the development and progression of human cancers. In this study, we analyzed 30 gallbladder
carcinomas to investigate the role of genetic alterations in their tumorigenesis, and to study correlations with their clinicopathological
features. Tissue samples were obtained from 30 patients with gallbladder carcinoma (11 men and 19 women; mean age, 62 years;
age range, 38–80 years). Genomic DNAs were extracted from fresh tumor tissue. We examined loss of heterozygosity (LOH) in
the p53, APC, DCC, RB, and NM23-H1 gene regions by polymerase chain reaction (PCR)-LOH assay using an automated fluorescent DNA sequencer employing four microsatellite
markers (p53, APC, DCC, NM23-H1). Five additional microsatellite markers were used for the determination of microsatellite
instability (MSI). LOH was found at p53 in 9 of 15 informative cases (60%), at DCC in 10 of 22 (45%), at APC in 5 of 15 (33%), at RB in 1 of 8 (13%), and at NM23-H1 in 1 of 15 (7%). MSI was observed in 5 of 30 cases (17%) in at least one chromosomal loci of these nine microsatellite markers.
None of the patients with MSI-positive tumors showed lymph node metastasis, and there was an inverse correlation between MSI
and the presence of LOH in gallbladder carcinoma. These results suggest that there are two independent genetic pathways in
gallbladder carcinogenesis; that is, an MSI pathway and an LOH pathway.
Received: December 24, 1999 / Accepted: May 26, 2000 相似文献
98.
Ryushi Shudo Takeshi Obara Satoshi Tanno Tsuneshi Fujii Noriyuki Nishino Miho Sagawa Hitoshi Ura Yutaka Kohgo 《Journal of gastroenterology》1998,33(2):289-294
"Groove pancreatitis", a form of segmental pancreatitis affecting the head of the pancreas, is local-ized within the "groove"
between pancreas head, duo-denum, and common bile duct. Differentiation between groove pancreatitis and pancreatic head carcinoma
is often difficult. We report a case of groove pancreatitis in which a hypoechoic mass between the duodenal wall and pancreas
was clearly imaged, and narrowing of the second portion of the duodenum and bile duct stenosis were also found. The diagnosis
was confirmed by surgery (pylorus-preserving pancreato duodenectomy). The patient was relieved from abdominal pain post operation.
Up to the present, the patient has been good condition. We review the clinicopathologic and radiologic features of groove
pancreatitis in the Japanese literature and discuss the possible role of Santorini's duct in its pathogenesis. We consider
that impacted protein plugs in Santorini's duct are a pathogenic factor in the development of groove pancreatitis. Therefore,
the findings of Santorini's duct on endoscopic retrograde pancreatography are very important in the diagnosis of groove pancreatitis.
Groove pancreatitis presents various clinical features, such as biliary stenosis, duodenal stenosis, and pancreatic mass,
and often masquerades as pancreatic head carcinoma. This condition should be kept in mind in the differential diagnosis of
pancreatic head carcinoma.
(Received Apr. 17, 1997; accepted Sept. 26, 1997) 相似文献
99.
OBJECTIVE: To assess changes in response to nasal continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea syndrome (OSAS) concerning excessive daytime sleepiness (EDS), depressive state, and quality of life (QOL). PATIENTS AND METHODS: We assessed for EDS using the Epworth sleepiness scale (ESS), for mood using The Zung self-depression scale (SDS), and for QOL using Short-Form 36 (SF-36) in 132 patients with obstructive sleep apnea syndrome (OSAS) and control subjects. Patients had severe OSAS (apnea-hypopnea index, 59.4+/-23.8/h) and were more hypersomnolent and depressed, and had poorer QOL than 38 age- and gender-matched controls. RESULTS: Before treatment most QOL domains in the SF-36 were significantly associated with patients' SDS scores. With nasal CPAP, ESS and SDS scores were respectively decreased from 9.7+/-4.5 to 4.0+/-2.4 (p<0.0001) and from 49.2+/-10.4 to 45.1+/-9.6 (p<0.0005). Total SF-36 score and scores for seven of eight domains were increased significantly with treatment. Thus, nasal CPAP lessens EDS and depression, and improves QOL, in patients with severe OSAS. Further, magnitudes of changes in total SF-36 scores and in five of eight domains correlated significantly with magnitude of change in SDS score upon nasal CPAP treatment. No relationship was evident between treatment-associated score changes in SF-36 domains and ESS score change. CONCLUSION: Although patients with severe OSAS have poorer QOL than control subjects, nasal CPAP appears to improve QOL by alleviating depression. 相似文献
100.
Osteoclast (OC) differentiation requires that precursors, such as macrophage colony-stimulating factor (M-CSF)-dependent bone marrow macrophages, receive signals transduced by receptor activator of nuclear factor kappaB (RANK) and c-Fms, receptors for RANK ligand (RANKL) and M-CSF, respectively. Activated c-Fms autophosphorylates cytoplasmic tail tyrosine residues, which, by recruiting adaptor molecules, initiate specific signaling pathways. To identify which tyrosine residues are involved in c-Fms signaling in primary cells, we retrovirally transduced M-CSF-dependent bone marrow macrophages with a chimera comprising the external domain of the erythropoietin (Epo) receptor linked to the transmembrane and cytoplasmic domains of c-Fms. Transduced cells differentiate into bone-resorbing osteoclasts when treated with RANKL and either M-CSF or Epo, confirming that both endogenous and chimeric receptors transmit osteoclastogenic signals. Cells expressing chimeric receptors with Y(697)F, Y(706)F, Y(721)F, and Y(921)F single point mutations generate normal numbers of bone-resorbing OCs, with normal bone-resorbing activity when treated with RANKL and Epo. In contrast, those expressing Y(559)F generate fewer OCs, whereas theY807F mutant is incapable of osteoclastogenesis. Finally, although mature OCs expressing Y(559)F exhibit impaired bone resorption, those bearing Y807F do not. Thus, we have identified specific tyrosine residues in the cytoplasmic tail of c-Fms that are critical for transmitting M-CSF-initiated signals individually required for OC formation or function, respectively. 相似文献