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71.
Pilar Nicolás 《Hereditary cancer in clinical practice》2007,5(3):144-152
The specific characteristics of genetic data lead to ethical-legal conflicts in the framework of genetic diagnosis. Several international organisations, including UNESCO and the Council of Europe, have enacted rules referring to the use of genetic information. This paper discusses possible legal and ethical criteria that could be used in genetic testing. 相似文献
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Sergio Barroilhet Adrián Cano-Prous Salvador Cervera-Enguix Maria João Forjaz Francisco Guillén-Grima 《Social psychiatry and psychiatric epidemiology》2009,44(12):1051-1065
Introduction
This paper presents the results of a study on the psychometric properties of an authorized Spanish version of the McMaster Family Assessment Device, a self-report measure of family functioning. 相似文献75.
76.
Hong Wang Venkatraman Siddharthan Jeffery O. Hall John D. Morrey 《Journal of neurovirology》2009,15(4):293-299
Prior findings led us to hypothesize that West Nile virus (WNV) preferentially transports along motor axons instead of sensory
axons. WNV is known to undergo axonal transport in cell culture and in infected hamsters to infect motor neurons in the spinal
cord. To investigate this hypothesis, WNV was injected directly into the left sciatic nerve of hamsters. WNV envelope-staining
in these hamsters was only observed in motor neurons of the ipsilateral ventral horn of the spinal cord, but not in the dorsal
root ganglion (DRG). To evaluate the consequence of motor neuron infection by WNV, the authors inoculated wheat germ agglutinin—horseradish
peroxidase (WGA-HRP) 9 days after WNV sciatic nerve injection, and stained the spinal cord and the DRG for HRP activity 3
days later. The degree of HRP-staining in DRG was the same in WNV- and sham-infected animals, but the HRP-staining in the
motor neuron in the ventral horn was considerably less for WNV-infected hamsters. To investigate the mechanism of WNV transport,
hamsters were treated with colchicine, an inhibitor of membranous microtubule-mediated transport. The intensity of the WNV-stained
area in the spinal cord of colchicine-treated hamsters at 6 days after WNV infection were significantly reduced (P≤.05) compared to the placebo-treated hamsters. These data suggest that WNV is preferentially transported through the motor
axons, but not the sensory axons, to subsequently infect motor neurons and cause motor weakness and paralysis. 相似文献
77.
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79.
Introduction
Although ependymoma is the third most common pediatric brain tumor, we know little about the genetic/epigenetic basis of its initiation, maintenance, or progression. This is due in part to the heterogeneity of the disease, as well as the small sample size of the cohorts analyzed in most studies. 相似文献80.
Peter Angelos 《World journal of surgery》2009,33(4):609-611