The ileal and colic microcirculation by the thrombosis and thromboembolism of mesenterial arteries

Quantitative and functional parameters of regional intestinal blood circulation were intraoperatively investigated with the use of laser Doppler flowmetry. The first group consisted of patients with necrotized parts of the intestine, while the second (control) group consisted of flowmetry data from intact intestine. Such indexes, as basal circulation, variation coefficient, blood oxygen perfusion saturation index, maximal perfusion amplitude of endothelial, neurogenic and myogenic oscillations in the intestinal volume, were showed to be valuable for the intestinal viability assessment. Thus, the method of the intraoperative laser Doppler flowmetry can be useful for determining the volume of intestinal resection.     

Structure of the optic canal in human ontogenesis.

The aim of this work is to reveal the optic canal (OC) development regularities. It is of importance to identify the anatomical preconditions of tunnel syndrome and other pathologies of the OC. One hundred and five human embryos (195 OC, out of them 98 - left-hand, 97 - right-hand) from 4 up to 70 mm parietococcygeal length (PCL) have been studied. The diameters of the optic nerve (ON) and OC in its orbital, cranial apertures and middle part have been defined. In the same way the distances between the OC walls and the ON and ophthalmic artery have been measured. We have come to the conclusion that the morphogenesis of the OC walls is an asynchronous process. The development of the OC upper wall is retarded. Some asymmetry of the morphometric characteristics of the right and left OC has been revealed. The development of the OC depends on the organization of all its elements. The periods of the OC development have been identified. The OC constitutional features of its aperture form, the size of the OC walls and its apertures, ON size, the correlation between ON and OC diameters of the OC cranial and orbital apertures and "waist", and the arrangement of the OC compartments were revealed. The individual and typical features of the OC structure, revealed as a result of computer tomography (CT) analysis, account for CT effectiveness in the diagnosis of OC changes and the structures located in it.     

Significance of bone marrow endothelial progenitor cells in disturbance of angiogenesis and endothelial dysfunction in systemic scleroderma

The study is aimed to investigate the process of endothelial repair related to endothelial progenitor cells (EPC) in systemic sclerosis (SS), and analyze the role of EPC abnormalities in endothelial dysfunction and impaired angiogenesis. Correlation between EPC circulating levels, measured by flowcytometry, and peripheral vascular manifestations, cardiac involvement, carotid artery disease, Framingham risk factor score, endothelial function and morphological signs of microangiopathy is explored. Our data demonstrate, that EPC reduction with disease progression is closely linked with endothelial dysfunction and destructive microangiopathy, and significantly contribute into development of severe cardiac disease and pulmonary hypertension in SS patients.     

Chlamydia Pneumoniae and Immunoinflammatory Reactions in an Unstable Atherosclerotic Plaque in Humans

Bulletin of Experimental Biology and Medicine - Comparative study of the walls of the aorta, coronary artery, and a. basilaris detected for the first time intra- and extracellular depositions of...