全文获取类型
收费全文 | 3774110篇 |
免费 | 301432篇 |
国内免费 | 14674篇 |
学科分类
医药卫生 | 4090216篇 |
出版年
2021年 | 55578篇 |
2020年 | 35376篇 |
2019年 | 58468篇 |
2018年 | 72701篇 |
2017年 | 55482篇 |
2016年 | 61340篇 |
2015年 | 75096篇 |
2014年 | 109308篇 |
2013年 | 174716篇 |
2012年 | 104254篇 |
2011年 | 106093篇 |
2010年 | 120667篇 |
2009年 | 123614篇 |
2008年 | 92688篇 |
2007年 | 97253篇 |
2006年 | 106746篇 |
2005年 | 101517篇 |
2004年 | 103234篇 |
2003年 | 93174篇 |
2002年 | 82527篇 |
2001年 | 136046篇 |
2000年 | 129598篇 |
1999年 | 121969篇 |
1998年 | 68576篇 |
1997年 | 65255篇 |
1996年 | 62985篇 |
1995年 | 58534篇 |
1994年 | 52522篇 |
1993年 | 48887篇 |
1992年 | 85020篇 |
1991年 | 80942篇 |
1990年 | 76652篇 |
1989年 | 75091篇 |
1988年 | 69003篇 |
1987年 | 67190篇 |
1986年 | 63524篇 |
1985年 | 62751篇 |
1984年 | 54862篇 |
1983年 | 49568篇 |
1982年 | 43614篇 |
1981年 | 40985篇 |
1980年 | 38453篇 |
1979年 | 44837篇 |
1978年 | 38232篇 |
1977年 | 34912篇 |
1976年 | 31958篇 |
1975年 | 30781篇 |
1974年 | 32475篇 |
1973年 | 31174篇 |
1972年 | 29029篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
Methicillin‐resistant Staphylococcus aureus eradication in young infants should include the diaper area and treat housing contacts 下载免费PDF全文
72.
73.
74.
75.
76.
77.
Rishad R. Jivani Gaurang J. Lakhtaria Dhaval D. Patadiya Laxman D. Patel Nurrudin P. Jivani Bhagyesh P. Jhala 《Saudi Pharmaceutical Journal》2016,24(1):1-20
Advancement in microelectromechanical system has facilitated the microfabrication of polymeric substrates and the development of the novel class of controlled drug delivery devices. These vehicles have specifically tailored three dimensional physical and chemical features which together, provide the capacity to target cell, stimulate unidirectional controlled release of therapeutics and augment permeation across the barriers. Apart from drug delivery devices microfabrication technology’s offer exciting prospects to generate biomimetic gastrointestinal tract models. BioMEMS are capable of analysing biochemical liquid sample like solution of metabolites, macromolecules, proteins, nucleic acid, cells and viruses. This review summarized multidisciplinary application of biomedical microelectromechanical systems in drug delivery and its potential in analytical procedures. 相似文献
78.
Erin C. Tully Jackson M. Gray Sherryl H. Goodman Stephen Nowicki Jr. 《Early child development and care》2016,186(12):1939-1951
Children who expect they can bring about good outcomes and avoid bad outcomes tend to experience more personal successes. Little is known about factors that contribute to these ‘control expectancies’. The purpose of the present study was to determine whether children's internal control expectancies occur in the context of parents’ internal control expectancies, low family strain, and high family cohesiveness and whether these factors are more strongly related to daughters’ than sons’ control expectancies. A community sample of 85 children aged 9–11 years and their parents (85 mothers; 63 fathers) completed rating scales. Fathers’ more internal control expectancies and mothers’ reports of fewer family strains were associated with daughters’ but not sons’ greater internal control expectancies, and greater family cohesiveness was related to both daughters’ and sons’ internal control orientations. These findings suggest that family factors may contribute to children's, particularly daughters’, development of internal control expectancies. 相似文献
79.
Dalton Luiz Schiessel Ricardo K. Yamazaki Marcelo Kryczyk Isabela Coelho de Castro Adriana A. Yamaguchi Danielle C. T. Pequito 《Nutrition and cancer》2016,68(8):1369-1380
Objective: Polyunsaturated fatty acids n-3 (PUFA n-3) have shown effects in reducing tumor growth, in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) abundantly present in fish oil (FO). When these fatty acids are provided in the diet, they alter the functions of the cells, particularly in tumor and immune cells. However, the effects of α-linolenic fatty acid (ALA), which is the precursor of EPA and DHA, are controversial. Thus, our objective was to test the effect of this parental fatty acid. Methods: Non-tumor-bearing and tumor-bearing Wistar rats (70 days) were supplemented with 1 g/kg body weight of FO or Oro Inca® (OI) oil (rich in ALA). Immune cells function, proliferation, cytokine production, and subpopulation profile were evaluated. Results: We have shown that innate immune cells enhanced phagocytosis capacity, and increased processing and elimination of antigens. Moreover, there was a decrease in production of pro-inflammatory cytokines (tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6)) by macrophages. Lymphocytes showed decreased proliferation capacity, increased cluster of differentiation 8 (CD8+) subpopulation, and increased TNF-α production. Conclusions: Oil rich in ALA caused similar immune modulation in cancer when compared with FO. 相似文献
80.
M. R. D. Maslin S. K. Lloyd S. Rutherford S. Freeman A. King D. R. Moore K. J. Munro 《Journal of the Association for Research in Otolaryngology》2015,16(5):631-640
Individuals with sudden unilateral deafness offer a unique opportunity to study plasticity of the binaural auditory system in adult humans. Stimulation of the intact ear results in increased activity in the auditory cortex. However, there are no reports of changes at sub-cortical levels in humans. Therefore, the aim of the present study was to investigate changes in sub-cortical activity immediately before and after the onset of surgically induced unilateral deafness in adult humans. Click-evoked auditory brainstem responses (ABRs) to stimulation of the healthy ear were recorded from ten adults during the course of translabyrinthine surgery for the removal of a unilateral acoustic neuroma. This surgical technique always results in abrupt deafferentation of the affected ear. The results revealed a rapid (within minutes) reduction in latency of wave V (mean pre = 6.55 ms; mean post = 6.15 ms; p < 0.001). A latency reduction was also observed for wave III (mean pre = 4.40 ms; mean post = 4.13 ms; p < 0.001). These reductions in response latency are consistent with functional changes including disinhibition or/and more rapid intra-cellular signalling affecting binaurally sensitive neurons in the central auditory system. The results are highly relevant for improved understanding of putative physiological mechanisms underlying perceptual disorders such as tinnitus and hyperacusis. 相似文献