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Indian Journal of Pediatrics - Acute rheumatic fever (ARF) and its sequelae, Rheumatic heart disease (RHD), contribute significantly to the cardiovascular morbidity and mortality in developing... 相似文献
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Phukan Pranjal Barman Bhupen Chengappa Nivedita Kharkongor Lynser Donboklang Paul Subhraneel Nune Arvind Sarma Kalyan 《Clinical rheumatology》2022,41(10):3169-3177
Clinical Rheumatology - The pathophysiology of neuropsychiatric manifestations in rheumatoid arthritis is not well known. The magnetic resonance imaging of the brain in rheumatoid arthritis... 相似文献
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V. Anuradha Arvind Chopra Allan S. Sturgess John P. Edmonds 《International journal of rheumatic diseases》2004,7(1):13-18
Aim: To evaluate indirect immunoenzyme (IIE) technique, for detection of antinuclear antibodies (ANA) using serum and filter paper blood clots (FPBC) especially for screening. Methods: Antinuclear antibody processing from FPBC (prepared by expressing blood drops by finger pricking) was standardized in a pilot study. Paired samples (serum and corresponding FPBC) from 224 individuals [142 patients of systemic rheumatic diseases, chiefly lupus and rheumatoid arthritis (RA) and 82 healthy controls (HC)] were tested by the standard immunofluorescence (IIF) and IIE (using light microscope); samples were coded, blinded and randomly processed as per the protocol. End‐point titres were determined for positive serum samples only. Standard reagents (Immunoconcepts Incorporation, US) and controls (CDC, Atlanta, US) were used. All patients were identified in a rheumatology referral practice in an Indian metropolis. Results: The sensitivity of IIE and IIF for SLE, using serum and FPBC was ≈90%. The specificity of IIE and IIF for SLE, using serum and FPBC was in the range 66–73% and 58–63%, respectively. Good–perfect agreement (κ > 0.8) between the results was obtained by IIE and IIF for all groups except RA. Except the RA group, all other paired samples showed good concordance (72%) on testing for ANA patterns by both techniques. Conclusions: Indirect immunoenzyme technique is a robust technique and should be considered a viable option to IIF at least in countries like India; its further use on FPBC is a socioeconomically appealing proposition for carrying out population studies on lupus and related uncommon connective tissue disorders. 相似文献
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Stephen J. Huang Marek Nalos Louise Smith Arvind Rajamani Anthony S. McLean 《Intensive care medicine》2018,44(6):868-883
Purpose
Many echocardiographic indices (or methods) for assessing right ventricular (RV) function are available, but each has its strengths and limitations. In some cases, there might be discordance between the indices. We conducted a systematic review to audit the echocardiographic RV assessments in critical care research to see if a consistent pattern existed. We specifically looked into the kind and number of RV indices used, and how RV dysfunction was defined in each study.Methods
Studies conducted in critical care settings and reported echocardiographic RV function indices from 1997 to 2017 were searched systematically from three databases. Non-adult studies, case reports, reviews and secondary studies were excluded. These studies’ characteristics and RV indices reported were summarized.Results
Out of 495 non-duplicated publications found, 81 studies were included in our systematic review. There has been an increasing trend of studying RV function by echocardiography since 2001, and most were conducted in ICU. Thirty-one studies use a single index, mostly TAPSE, to define RV dysfunction; 33 used composite indices and the combinations varied between studies. Seventeen studies did not define RV dysfunction. For those using composite indices, many did not explain their choices.Conclusions
TAPSE seemed to be the most popular index in the last 2–3 years. Many studies used combinations of indices but, apart from cor pulmonale, we could not find a consistent pattern of RV assessment and definition of RV dysfunction amongst these studies.30.
Devbrat Yadav Arvind Kumar Pramod Kumar Diwaker Mishra 《Indian journal of pharmacology》2015,47(6):663-667