Porous biodegradable polyester blends of poly(L‐lactic acid) and poly(ε‐caprolactone): physical properties,morphology, and biodegradation

Poly(L ‐lactic acid) (PLLA), poly(ε‐caprolactone) (PCL), and their films without or blended with 50 wt% poly(ethylene glycol) (PEG) were prepared by solution casting. Porous films were obtained by water‐extraction of PEG from solution‐cast phase‐separated PLLA‐blend‐PCL‐blend‐PEG films. The effects of PLLA/PCL ratio on the morphology of the porous films and the effects of PLLA/PCL ratio and pores on the physical properties and biodegradability of the films were investigated. The pore size of the blend films decreased with increasing PLLA/PCL ratio. Polymer blending and pore formation gave biodegradable PLLA‐blend‐PCL materials with a wide variety of tensile properties with Young's modulus in the range of 0.07–1.4 GPa and elongation at break in the range 3–380%. Pore formation markedly increased the PLLA crystallinity of porous films, except for low PLLA/PCL ratio. Polymer blending as well as pore formation enhanced the enzymatic degradation of biodegradable polyester blends. Copyright © 2006 Society of Chemical Industry     

Decremental oscillation curve fitting of heart rate response following face immersion into cold water

Sociodemographic differences between rural and urban clients with severe mental illness (SMI) are explored using approaches which extend research in this area beyond limitations found in the few existing studies. Sixteen hundred adult clients from 18 Wisconsin counties are classified according to the degree of rurality of their counties of residence, using two definitions: a dichotomous metropolitan-non-metropolitan grouping and population density. There are significant differences between rural and urban clients for age, gender, and marital status, but not education or income. Young (18-35 years), unmarried males are more likely to live in more densely populated counties. Older (65 and older) women who are currently or previously married are more likely to live in less densely populated counties.     

Fundamental investigation of plug conveying of cohesionless particles in a vertical pipe (pressure drop and friction of a stationary plug)

A stationary packed bed of cohesionless particles is set up in a vertical pipe for the fundamental study of plug conveying. The effect of flow acceleration or deceleration on the pressure drop of the plug is investigated first. It is found that the pressure drop increases due to the flow acceleration and vice versa. Next, the following three kinds of experiments were made for the study of friction characteristics: 1. Friction between the plug and moving wall without air flow, 2. Friction between the plug and wall with downward air flow, 3. Friction between the plug and wall with upward air flow. The results are compared with the theory established in powder mechanics. The state of stress being of the active or passive case is discussed. Finally the problem of particles raining down from the back of the plug is studied. It is shown that the air velocity necessary to support the particles can be calculated based on a simple analysis of pressure distribution around the particles.     

A highly integrated 40-MIPS (peak) 64-b RISC microprocessor

A 1-million transistor 64-b microprocessor has been fabricated using 0.8-μm double-metal CMOS technology. A 40-MIPS (million instructions per second) and 20-MFLOPS (million floating-point operations per second) peak performance at 40 MHz is realized by a self-clocked register file and two translation lookaside buffers (TLBs) with word-line transition detection circuits. The processor contains an integer unit based on the SPARC (scalable processor architecture) RISC (reduced instruction set computer) architecture, a floating-point unit (FPU) which executes IEEE-754 single- and double-precision floating-point operations a 6-KB three-way set-associative physical instruction cache, a 2-KB two-way set-associative physical data cache, a memory management unit that has two TLBs, and a bus control unit with an ECC (error-correcting code) circuit     

On the increase of the intensity ratio of doubly charged ions to singly charged ions for liquid gold and copper ion sources.

The reason for the increase of R21 which is defined by the intensity ratio of the doubly charged ions to the singly charged ions, was studied. Based on the conventional field evaporation theory, an increase in the electric field and/or the source temperature is considered to be attributable. We took the fact that R21 turned to decrease at the higher current regime into consideration and examined whether the change of R21 due to change in the field or temperature would finally meet the criterion for the decrease of R21. It was concluded that an increase of the source temperature may be a possible reason for the increase of R21.     

Studies on anti-inflammatory agents. V. Synthesis and pharmacological properties of 3-(difluoromethyl)-1-(4-methoxyphenyl)-5- [4-(methylsulfinyl)phenyl]pyrazole and related compounds

A series of novel 1,5-diphenylpyrazole derivatives bearing hydrophilic substituents was prepared. The anti-inflammatory and analgesic activities of these compounds were evaluated by using the adjuvant arthritis and Randall-Selitto assays in rats, and the structure-activity relationships were studied. The optimal compound was 3-(difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl)phenyl]pyraz ole (10) with oral ED50 values of 0.31 and 2.6 mg/kg on adjuvant-induced arthritis and carrageenin-induced foot edema, respectively. Compound 10 showed analgesic activities not only toward inflamed paw but also toward normal paw (ED30 = 0.55 and 1.8 mg/kg, respectively) in the Randall-Selitto assay, and moreover, 10 was effective in the tail-pinch assay (ED50 = 21 mg/kg) similarly to morphine. The asymmetric synthesis and pharmacological properties of the enantiomers of 10 are also reported.     

Determination and survey of starting materials, intermediates, and subsidiary colors in food color of azo dye by high performance liquid chromatography

The number of official inspection of coal-tar dyes and their lakes from April in 1996 till March in 1997 were 581 in total. The quantity which passed inspection amounted to 164.5 ton in Japan. The production of color in each month was summarised in Table1, and by each producing company in Table2. The food coal-tar dye produced in the largest quantity was Food Yellow No. 4, occupying 43.4% in this period.     

Effect of voluntary exercise on maximal oxygen uptake in young female Fischer 344 rats

The effect of voluntary exercise on maximal oxygen uptake (VO2 max) was studied in young female Fischer 344 rats. After 10 weeks of wheel-running training, the absolute VO2 max and VO2 max relative to body mass increased without a decline in body mass. The running speed eliciting VO2 max, heart and soleus muscle mass, and succinate dehydrogenase (SDH) activity in the soleus muscle also increased. These results suggest that voluntary exercise is an effective means of increasing the aerobic exercise capacity of young female Fischer 344 rats.     

Role of adsorbed iodine into poly(vinyl alcohol) films drawn in KI/I2 solution

We have investigated the microstructure of the poly(vinyl alcohol) (PVA) films using small- and wide-angle X-ray scattering (SAXS and WAXS, respectively) techniques. The samples were uniaxially drawn in water or KI/I₂ aqueous solution and then dried in an air-oven at 333 K for 1 h prior to SAXS and WAXS measurements. It was found that for the films drawn in KI/I₂ solution PVA chains in the microfibrillar structure are more extended upon the film drawing compared to the case of the films drawn in pure water, which is resulted from the correlation function analysis on the SAXS data. Adsorbed iodines into the film were anticipated to act as junction points between the microfibrils via the formation of the PVA-iodine complexes.     

A new method for scanning electron microscopic visualization of dermal elastic fibres.

Autoclaving sections of dermis for 8 h followed by fixation, dehydration and xylol-air drying yields a pure preparation of elastic fibres for scanning electron microscopy which retains the native architecture of this component. Elastic fibres were intertwined in a complex fashion with numerous branches. Fibres were predominantly cylindrical in the upper dermis and became larger and more elliptical in the deeper dermis. This method produces a means to study of organization of elastic fibres in a variety of disorders in which dermal changes are prominent.