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61.
Y Eto K Nitta K Uchida T Tsutsui K Natori A Kawashima W Yumura H Nihei 《Canadian Metallurgical Quarterly》1997,60(11):PL193-PL199
We investigated the effects of the new 5-HT2A receptor antagonist, sarpogrelate, on DNA synthesis in renal mesangial cells stimulated with 5-HT in the presence and absence of platelet-derived growth factor (PDGF)-BB. Both 5-HT and PDGF-BB demonstrated a mitogenic effect on these cells. When mesangial cells were incubated in the absence of PDGF-BB, sarpogrelate inhibited DNA synthesis in these cells in a dose-dependent manner. In the presence of PDGF-BB, sarpogrelate had a weaker anti-mitogenic effect in mesangial cells stimulated with 5-HT. Sarpogrelate was cytotoxic at concentrations over 10(-5) M according to the results of LDH release assays, and it reduced the S1 phase in mesangial cells stimulated with 5-HT by a flow cytometry. These findings suggest that sarpogrelate may be effective in the treatment of some glomerulonephritis associated with mesangial cell proliferation. 相似文献
62.
Shunichi Hasegawa Takahiro Nishiwaki Hitoe Habuchi Shoji Nitta Shuichi Nonomura 《Fullerenes, Nanotubes and Carbon Nanostructures》1995,3(2):163-178
CPM spectra of the fullerene film was measured to obtain the below gap absorption. The optical energy gap Eo was obtained by using the Tauc's plots. Eo did not change so much with the intercalated impurities. The absorption due to intercalated impurities was found below 1.6eV. 相似文献
63.
The interactions of bis-2-(2-pyridylazo)-1-naphthol Co(III), [Co(III) (αPAN)2+], with five kinds of synthetic polyelectrolytes have been studied by spectrophotometric and transient electric dichroism measurements. The polyelectrolytes were: poly(styrene sulphonic acid) (PSS); poly(acrylic acid) (PAA); poly(l-glutamic acid) (PLG); (PDCML); and poly(l-lysine) (PLL). The equilibrium constant of the reaction:with P = polyelectrolyte residue was determined spectrophotometrically: K1 is > 107 M?1 (PSS); (1.4 ± 0.2) × 104 M?1 (PAA); (4.0 ± 0.4) × 103 M?1 (PLG); (1.4 ± 0.2) × 106 M?1 (PDCML); and < 102 M?1 (PLL) at pH 6–8. From transient electric dichroism, the angle (ψ) between the αPAN plane and the polymer axis was determined to be 65° (PSS); 52° (PAA); 55° (PLG); and 52° (PDCML). The large K1 and ψ values for PSS are ascribed to the hydrophobic interaction between the aromatic αPAN ring and the styrene sulphonate residues of PSS. Using stopped-flow electric dichroism measurements, rapid transfer of a bound Co(III) chelate from the PDCML to PSS chains was shown to occur. 相似文献
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66.
Active transport driven by molecular motors is a key technology for the continued miniaturization of lab-on-a-chip devices, because it is expected to enable nanofluidic devices with channel diameters of less than 1 microm and total channel lengths on the order of 1 mm. An important metric for a transport mechanism employed in an analytic device is dispersion, because it critically affects the sensitivity and resolution. Here, we investigate the mechanisms responsible for the dispersion of a swarm of "molecular shuttles", consisting of functionalized microtubules propelled by surface-adhered kinesin motor proteins. Using a simple model and measurements of the path persistence length, motional diffusion coefficient, and the distribution of average velocities, we found that, at the time scale relevant in the envisioned nanobiodevices, variations in the time-averaged velocities between shuttles will make a stronger contribution to the dispersion of the swarm than both the fluctuations around the time-averaged velocity of an individual shuttle and the fluctuations in path length due to wiggling within the channel. Overall, the dispersion of such molecular shuttles is comparable to the dispersion of a sample plug transported by electroosmotic flow. 相似文献
67.
The temperature dependence of resistivities of gas sensors made of SnO2, Pd-doped SnO2, and ThO2-doped SnO2 with Pd has been investigated in air containing reducing gases such as CO, H2, and C3H8. The curves for ThO2-doped sensors were significantly influenced by the reducing gases as compared to the sensors without ThO2. From these results, it is found that in Pd-doped SnO2 sensors the dopant plays an important role in oxidizing the surface of SnO2 above 170°C, and that the addition of ThO2 to Pd-doped SnO2 enhances the effects of Pd by removing the adsorbed hydroxyl on SnO2. It is also apparent that the interactions between reducing gases in air and SnO2-based sensors depend upon the oxidizing rates of the surface of SnO2, as well as the amounts of the adsorbed hydroxyl on SnO2. 相似文献
68.
Phase I and pharmacologic study of irinotecan in combination with cisplatin for advanced lung cancer
N Masuda M Fukuoka S Kudoh Y Kusunoki K Matsui N Takifuji K Nakagawa M Tamanoi T Nitta T Hirashima 《Canadian Metallurgical Quarterly》1993,68(4):777-782
Macroscopic T-type Ca2+ currents, which are often observed in fetal and neonatal cardiac muscle cells, were not found in normal (0 of 17) adult feline ventricular myocytes. However, they were present in most (15 of 21) myocytes isolated from adult feline left ventricles with long-standing pressure-overload-induced hypertrophy. This is the first study to provide evidence in a large mammal, such as the cat, that T-type Ca2+ channels may be reexpressed in adults in association with hypertrophy resulting from slow progressive pressure overload. Importantly, this expression was stable for the duration of the hypertrophy process and was not associated with abrupt pressure overload. T-type Ca2+ currents were separated from L-type Ca2+ currents by exploiting the differences in their voltage dependence of steady-state inactivation. Depolarizations from -80 mV revealed a rapidly activating inward current that peaked in magnitude at -30 mV (-1.8 +/- 0.9 [mean +/- SD] pA/pF) and fully inactivated within 100 milliseconds in 15 of 21 hypertrophied myocytes studied. Further depolarizations activated progressively less T-type Ca2+ current, so that at +10 mV the L-type Ca2+ current predominated. In the hypertrophied myocytes that demonstrated both T-type and L-type Ca2+ currents, two distinct peaks occurred in their current-voltage relations. T-type Ca2+ currents were not evident in any of the 17 normal adult feline left ventricular myocytes studied. The purpose of T-type Ca2+ currents in hypertrophy is unclear. However, their presence may make hypertrophied myocardium more prone to spontaneous action potentials and increase the likelihood for arrhythmias in partially depolarized hypertrophied myocardium. 相似文献
69.
Makoto Miyazawa Yasuhiko Irie Kazuki Kashimoto Naoko Nishina Mitsuru Kondo Sachiko Yasue Kenji Maeda Fumio Uchida 《Inorganic chemistry communications》2009,12(4):336-339
Three new complexes, [Zn(dbsf)2(dmf)2] · 5.5dmf (dbsf = 4,4′-sulfonyldibenzoate) (1β), [Cu(tdsa)(phen)2] · 1.5EtOH (tdsa = 5,5′-thiodisalicylate, phen = 1,10-phenanthroline) (2), and [Cu(sdp)(phen) · Cu(Hsdp)(phen)(CH3COO)] · 3EtOH (sdp = 4,4′-sulfonyldiphenolate) (3) were prepared and structurally characterized. Complex 1β shows a one-dimensional coordination framework constructed from bridges between Zn(II) centers with two ligands. Complex 2 is a monomeric complex, which assembles by π–π interactions. Complex 3 shows a unique two-dimensional coordination framework that is constructed from two Cu(II) centers, sdp, and Hsdp. The redox properties of these three complexes were characterized by solid-state cyclic voltammetry. Complexes 1β and 3 show irreversible reduction waves because of the reduction of their sulfone sites. Complex 2 shows an irreversible oxidation wave because of oxidation of the sulfide site. 相似文献
70.
Helena A. Soini Donald Wiesler Sachiko Koyama Christophe Féron Claude Baudoin Milos V. Novotny 《Journal of chemical ecology》2009,35(5):580-589
Whereas the house mouse (Mus domesticus) has been studied extensively in terms of physiology/behavior and pheromonal attributes, the evolutionarily related mound-building
mouse (Mus spicilegus) has received attention only recently due to its divergent behavioral traits related to olfaction. To date, no chemical studies
on urinary volatile compounds have been performed on M. spicilegus. The rationale for our investigations was to determine if there are differences in urinary volatiles of intact and castrated
M. spicilegus males and to explore further whether this species could utilize the same or structurally similar pheromones as the male house
mouse, M. domesticus. The use of capillary gas chromatography/mass spectrometry (GC-MS) together with sorptive stir bar extraction sampling enabled
quantitative comparisons between the intact and castrated M. spicilegus urinary profiles. Additionally, through GC-MS and atomic emission (sulfur-selective) detection, we identified qualitative
molecular differences between intact M. spicilegus and M. domesticus. A series of volatile and odoriferous lactones and the presence of coumarin were the unique features of M. spicilegus, as was the notable absence of 2-sec-butyl-4,5-dihydrothiazole (a prominent M. domesticus male pheromone) and other sulfur-containing compounds. Castration of M. spicilegus males eliminated several substances, including δ-hexalactone and γ-octalactone, and substantially decreased additional compounds,
suggesting their possible role in chemical communication. Some other M. domesticus pheromone components were also found in M. spicilegus urine. These comparative chemical analyses support the notion of metabolic similarities as well as the uniqueness of some
volatiles for M. spicilegus, which may have a distinct physiological function in reproduction and behavior. 相似文献