太赫兹超表面计算全息

全息术是一种三维成像技术,它已经被应用于多种实际场景。随着计算机科学与技术的迅猛发展,计算全息由于其方便和灵活的特性,已经成为一种广泛应用的全息成像方法。本文回顾了我们近期基于超表面的太赫兹计算全息研究进展。其中,作为全息板的超表面展示出了超越传统光学器件的独特性能。首先,利用超表面实现了对于全息板每个像素的相位振幅同时且独立的调控,进而实现了高质量全息成像。这种新的电磁波操控能力也带来了新的全息成像效果,如利用介质超表面实现了全息像沿传播方向上的连续变化。其次,对超表面在不同偏振态下的响应进行设计,分别实现了线偏振态与频率复用、圆偏振态复用、以及基于表面波的偏振复用超表面全息术。此外,本文提出了依赖于温度变化而主动可控的超表面全息术,为今后计算全息术的设计与实现提供了新的方案,也推动了超表面在实际应用方面的发展。     

Discovery of Affinity-Based Probes for Btk Occupancy Assays

Bruton's tyrosine kinase (Btk) is an attractive target for the treatment of a wide array of B-cell malignancies and autoimmune diseases. Small-molecule covalent irreversible Btk inhibitors targeting Cys481 have been developed for the treatment of such diseases. In clinical trials, probe molecules are required in occupancy studies to measure the level of engagement of the protein by these covalent irreversible inhibitors. The result of this pharmacodynamic (PD) activity provides guidance for appropriate dosage selection to optimize inhibition of the drug target and correlation of target inhibition with disease treatment efficacy. This information is crucial for successful evaluation of drug candidates in clinical trials. Based on the pyridine carboxamide scaffold of a novel solvent-accessible pocket (SAP) series of covalent irreversible Btk inhibitors, we successfully developed a potent and selective affinity-based biotinylated probe 12 (2-[(4-{4-[5-(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)pentanoyl]piperazine-1-carbonyl}phenyl)amino]-6-[1-(prop-2-enoyl)piperidin-4-yl]pyridine-3-carboxamide). Compound 12 has been used in Btk occupancy assays for preclinical studies to determine the therapeutic efficacy of Btk inhibition in two mouse lupus models driven by TLR7 activation and type I interferon.     

High-Tg porous polyimide films with low dielectric constant derived from spiro-(adamantane-2,9′(2′,7′-diamino)-fluorene)

Porous polyimide (PI) films with low dielectric constants and excellent thermal properties have been a pressing demand for the next generation of high-performance, miniature, and ultrathin microelectronic devices. A series of novel porous PI films containing fluorenyl-adamantane groups were prepared successfully via thermolysis of poly(ethylene glycol) (PEG) added in the PI matrix. The cross-sectional morphologies of porous PI films showed closed pores with diameters ranging from 135 to 158 nm, which were uniform and regular in shape without interconnectivity. These porous PI films exhibited excellent thermal properties with a glass-transition temperature at 376 °C whereas the 5% weight loss temperature in air excess of 405 °C due to enhanced rigidity afforded by fluorenyl-adamantane groups. Accompanied by thermolysis content of PEG increasing from 0 to 20 wt %, the density of porous PI films decreased, and the corresponding porosity grew significantly from 0 to 11.48%. Depending on porosity, the dielectric constant and dielectric loss of porous PI films significantly declined from 2.89 to 2.37 and from 0.050 to 0.021, respectively. These excellent properties benefit the as-prepared porous PI films for application as interlayer dielectrics, integrated circuit chips, or multichip modules in microelectronic fields. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47313.     

四川盆地上三叠统划分对比研究

四川盆地上三叠统对比长期存在混乱，给盆地整体评价带来困难。通过岩石地层、地震地层、事件地层及高分辨率旋回地层等多种方法讨论了须家河组与香溪群各岩性段的对比关系，得出了全盆地上三叠统的对比关系；指出须四段底可近似看成等时界面；须家河组下部地层自西向东、向南逐层超覆在雷口坡组之上，上部地层在盆地西北部自东南向西北方向剥蚀层位渐次变老。文章建议四川盆地上三叠统废除“香溪群”，统一使用“须家河组”，以利于对全盆地上三叠统进行油气资源整体评价与深化研究。     

强捻棉纱针织产品的性能研究

通过对强捻棉纱针织产品进行服用性能测试，得出强捻纱织物具有良好的服用性能。     

300 m级高拱坝设计与施工三维可视化仿真研究

双曲拱坝的C2连续曲面的三维模型表达困难,以双曲拱坝函数方程为基础引入CATIA三维软件,实现交互式设计和分析。同时,完成双曲拱坝细部模型的基于规则的智能化设计。基于大坝详细设计的三维成果,利用组件技术对模型数据进行提取和利用,制定施工方案并进行施工方案的动态可视化仿真。     

热声制冷机及其改进实验研究

热声制冷作为一种很有前途的制冷方法，在国内外相关领域引起了极大兴趣。热声制冷机由声发生器、共振管、板叠及高、低温换热器等部分组成。对声驱动器的振动膜及其冷却系统、气体弹簧系统、高、低温换热器进行了初步改进，使制冷机冷端温降从原来的12℃提高到27℃左右，这是目前国内报道的最大温降。     

ZnLiFeO_3高温热敏厚膜材料的研究

ＺｎＬｉＦｅＯ３（ＺＬＦ）高温ＮＴＣ热敏厚膜材料，是以尖晶石结构的ＺｎＬｉＦｅＯ３导电陶瓷作厚膜浆料的导电相，以Ａｌ２Ｏ３瓷为基体，用厚膜工艺制成的。实验表明，在氮气中烧结的ＺＬＦ厚膜材料，室温方阻１０３Ω／□级，Ｂ值约１０００Ｋ。在高温５００～７００℃范围内，方阻降为１０２Ω／□级，Ｂ值仍小于１０００Ｋ。是一种很有前途的高温热敏材料。     

故县大坝坝基泥化性F_5断层的化学灌浆防渗加固处理

泥化软化性F_5断层是故县大坝坝基范围内最大的一条断层,位于左岸,对左坝肩的稳定极为不利,采用水泥灌浆处理无效,故改用化学灌浆处理。选用EAA化学浆材,采用“优选组合配方综合施灌”的创新施工工艺,效果良好,为今后低渗透性复杂的泥化软化性断层的防渗加固处理,提供了新的依据和途径。     

无机复合微量元素肥料（FTE）的合成及其应用效果研究

重点研究了无机复合微肥（简称ＦＥＴ）的合成条件及生成规律，并详细探讨了组成、工艺对ＦＴＥ微肥的主要技术指标——枸溶性的影响。同时，介绍了粮、棉、果、菜等各类农作物施用ＦＴＥ后取得的显著效果，为ＦＥＴ在作物上大面积推广应用提供了理论和实践依据。