全文获取类型
收费全文 | 616篇 |
免费 | 10篇 |
国内免费 | 4篇 |
学科分类
工业技术 | 630篇 |
出版年
2022年 | 2篇 |
2021年 | 10篇 |
2020年 | 8篇 |
2019年 | 10篇 |
2018年 | 10篇 |
2017年 | 5篇 |
2016年 | 10篇 |
2015年 | 9篇 |
2014年 | 15篇 |
2013年 | 27篇 |
2012年 | 31篇 |
2011年 | 36篇 |
2010年 | 12篇 |
2009年 | 24篇 |
2008年 | 23篇 |
2007年 | 21篇 |
2006年 | 34篇 |
2005年 | 16篇 |
2004年 | 36篇 |
2003年 | 29篇 |
2002年 | 20篇 |
2001年 | 17篇 |
2000年 | 11篇 |
1999年 | 13篇 |
1998年 | 32篇 |
1997年 | 25篇 |
1996年 | 19篇 |
1995年 | 15篇 |
1994年 | 5篇 |
1993年 | 14篇 |
1992年 | 7篇 |
1991年 | 3篇 |
1989年 | 7篇 |
1988年 | 3篇 |
1987年 | 6篇 |
1986年 | 7篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 7篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1978年 | 8篇 |
1977年 | 3篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有630条查询结果,搜索用时 15 毫秒
91.
Advanced glycation end-products (AGE) play a role in the pathogenesis of several diseases, including diabetic complications and atherosclerosis. In atherosclerotic lesions of human aortas, AGE are localized in the extracellular matrix and intracellularly in foam cells. Two interpretations are possible for AGE accumulation inside macrophages, one is endocytic uptake of extracellular AGE-proteins by scavenger receptors; the other is intracellular AGE formation inside the macrophages. In the present study, we determined the pathways involved in AGE accumulation inside macrophages. RAW 264.7 cells, a murine macrophage cell line, incubated with BSA and 1600 mM glucose for 40 weeks, recognized heavily modified AGE- BSA. In contrast, the cells showed no ligand activity for mildly modified AGE-BSA, prepared by incubating BSA with 50 mM glucose for 24 weeks. Nepsilon-(carboxymethyl)lysine (CML)-modified proteins of about 65 kDa were detected in human monocyte-derived macrophages incubated for 7 days with 30 mM glucose and phorbol myristate acetate. Furthermore, CML was generated when glycated protein was incubated with hypochloric acid. Taken together, our results indicate that AGE detected inside foam cells in atherosclerotic lesions are generated intracellularly rather than representing endocytic uptake of extracellular AGE-proteins by scavenger receptors. 相似文献
92.
Katsumi Tsuchiya Masanobu Koshihata Tahei Tomida Takayuki Saito 《Korean Journal of Chemical Engineering》1999,16(5):635-639
The dynamic process of gas absorption from a CO2 bubble into a liquid is examined in the presence of satellite bubbles. The bubble under consideration is held stationary,
except its jittering, by the liquid flowing downward. The mass transfer rate is determined by monitoring the rate of reduction
in the equivalent bubble diameter during the initial absorption process. It is found that the interaction with the satellite
bubbles generally hampers the dissolution of the primary bubble. The extent of reduction in the dissolution rate increases
with the net contacting time during the interaction. When the secondary bubbles interact with the primary bubble mainly outside
of its wake, however, the dissolution tends to be enhanced due to induced turbulence in the surrounding liquid flow. A simple
theoretical model is developed to simulate the observed results as well as the basic features prevailing in a recently proposed
scheme, called the GLAD system, for shallow injection of CO2 gas into seawater. 相似文献
93.
Toshiyuki Nagata Kentaro Minami Masatatsu Yamamoto Tsubasa Hiraki Masashi Idogawa Katsumi Fujimoto Shun Kageyama Kazuhiro Tabata Kohichi Kawahara Kazuhiro Ueda Ryuji Ikeda Yukio Kato Masaaki Komatsu Akihide Tanimoto Tatsuhiko Furukawa Masami Sato 《International journal of molecular sciences》2021,22(21)
94.
95.
96.
In high‐level synthesis, scheduling is an important stage which assigns each operation appearing in a data flow graph to a specific control step, whose results influence the design quality directly. This paper describes a scheduling approach for pipelined datapaths. Since few previous approaches estimate the interconnection cost between register (register‐to‐register cost), our approach introduces a datapath model with interconnection between registers across buses, and minimizes the total hardware cost including the register‐to‐register cost by force‐directed scheduling. © 1999 Scripta Technica, Electr Eng Jpn, 128(3): 63–71, 1999 相似文献
97.
Approximately 20,000 ha of densely built-up areas still remain in Japan. However, the advance of improvements in these areas has been very slow. Thus, making draft improvement plans through citizen–administration partnerships is indispensable to promote improvements. The planning support tool proposed in this study supports a consensus-building process during the creation of draft improvement plans. We develop a disaster mitigation performance evaluation method (DMPEM) for built-up areas at the district level and incorporate this method into a disaster mitigation support Web-GIS. However, DMPEM requires lengthy calculation time because it uses the probabilistic Monte Carlo computation method. Using this tool in real- time planning is therefore difficult. In this study, we first develop a system that reduces the calculation time required by DMPEM. Second, the support tool is used to make draft plans through citizen–administration partnerships in districts where residents are conducting various disaster mitigation activities. Finally, we investigate the usefulness of the tool for consensus building through the promotion of lively discussions among residents and clarify the issues associated with practical use of the tool. 相似文献
98.
Tomohiko Yamanashi Tatsuya Hatori Yoshito Ishihara Norihisa Kawashima Katsumi Niwa 《Architectural Design》2011,81(6):100-107
Numbering 65, Nikken Sekkei's research group is the size of many substantial practices. Tomohiko Yamanashi, Tatsuya Hatori, Yoshito Ishihara and Norihisa Kawashima at Nikken Sekkei Ltd and Katsumi Niwa at the Nikken Sekkei Research Institute (NSRI) describe the unique collaborative processes that make the NSRI's contribution essential to any Nikken projects requiring the development of cutting-edge technology or urban planning proposals. Here, they detail the development of BIO SKIN, an innovative facade system developed for the Sony Research and Development Center in Tokyo, which addresses the urban heat island effect, one of the main environmental research areas of the NSRI. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
99.
Kondo A Noguchi H Ohnishi S Kajiro H Tohdoh A Hattori Y Xu WC Tanaka H Kanoh H Kaneko K 《Nano letters》2006,6(11):2581-2584
Crystal-to-crystal transformation from a 3D interpenetrated-type MOF {[Cu(BF(4))(2)(bpy)(H(2)O)(2)] (bpy)} (1) to a 2D square-grid-type [Cu(BF(4))(2)(bpy)(2)] (2) (bpy = 4,4'-bipyridine) was observed. It was derived from dehydration and confirmed by in situ FT-IR, TG, and elemental analysis. Moreover, we elucidate the novel expansion/shrinkage dynamic modulation of 2 triggered by clathrate formation with gas molecules. 相似文献
100.
Receptor internalization is a useful indicator of the activity of ligands. The N-terminus of the β(2)-adrenergic receptor expressed on the cell surface was labeled with fluorophores using a novel coiled-coil labeling system. Endocytosis of the receptors was automatically detected using a fluorescence image analyzer by evaluating (1) translocation of the receptor from cell-surface to intracellular regions and (2) acidification in endosomes. Both parameters increased upon agonist stimulation in a dose-dependent manner. The extent of endocytosis was significantly dependent on the agonist used, indicating the presence of a biased signaling for endocytosis. The receptor antagonists can also be screened by competitive inhibition of agonist-induced endocytosis. The image analysis approach has proven to be useful for high-throughput characterization and screening of GPCR ligands. 相似文献