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11.
The main weakness of elastic optical networks (EON), under dynamic traffic conditions, stems from spectrum fragmentation. A lot of research efforts have been dedicated during recent years to spectrum defragmentation. In this work, a thorough study about proactive defragmentation is carried out. Effects of the different defragmentation parameters on the EON performance are analyzed, and appropriate values of the defragmentation period, which guarantee suitable network performance while keeping the network control complexity at reasonable values, are obtained by means of extensive simulations. Benefit obtained by applying different defragmentation strategies, in terms of increase in the supported load at a given bandwidth blocking probability, is also reported. Different traffic conditions and network topologies are simulated to assess the validity of the obtained results. 相似文献
12.
Juan Morote Anna Celma Jacques Planas José Placer Inés de Torres Mireia Olivan Juan Carles Jaume Reventós Andreas Doll 《International journal of molecular sciences》2014,15(8):13615-13623
The aim of this study was to analyze the relationship between statin use along with serum cholesterol levels and prostate cancer (PCa) detection and aggressiveness. Statin users of three years or more and serum cholesterol levels (SC) were assessed in 2408 men scheduled for prostate biopsy. SC was classified as normal (NSC: <200 mg/dL) or high (HSC: >200 mg/dL). High-grade PCa (HGPCa) was considered if the Gleason score was greater than 7. Statin users comprised 30.9% of those studied. The PCa detection rate was 31.2% of men on statins and 37% of non-statin users (p < 0.006). The PCa detection rate was 26.3% in men with NSC and 40.6% in those with HSC (p < 0.001). In the subset of NSC men, the PCa rate was 26.5% for statin users and 26.2% for non-users (p = 0.939), while in men with HSC, the PCa rate was 36.4% for statin users and 42.0% for non-statin users (p = 0.063). The HGPCa rate was 41.8% for statin users and 32.5% for non-users (p = 0.012). NSC men had a 53.8% rate of HGPCa, while the rate was only 27.6% in HSC men (p < 0.001). NSC men on statins had an HGPCa rate of 70.2%, while non-statin users had a rate of 41.2% (p < 0.001). The HGPCa rate for HSC men on statins was 18.8%, while the rate was 30.0% (p = 0.011) for non-users. Logistic regression analysis suggested that serum cholesterol levels could serve as an independent predictor of PCa risk, OR 1.87 (95% CI 1.56–2.24) and HGPCa risk, OR 0.31 (95% CI 0.23–0.44), while statin usage could not. Statin treatment may prevent PCa detection through serum cholesterol-mediated mechanisms. A disturbing increase in the HGPCa rate was observed in statin users who normalized their serum cholesterol. 相似文献
13.
14.
M. Jaume 《Journal of Automated Reasoning》1999,23(3):347-371
This paper presents a full formalization of the semantics of definite programs, in the calculus of inductive constructions. First, we describe a formalization of the proof of first-order terms unification: this proof is obtained from a similar proof dealing with quasi-terms, thus showing how to relate an inductive set with a subset defined by a predicate. Then, SLD-resolution is explicitely defined: the renaming process used in SLD-derivations is made explicit, thus introducing complications, usually overlooked, during the proofs of classical results. Last, switching and lifting lemmas and soundness and completeness theorems are formalized. For this, we present two lemmas, usually omitted, which are needed. This development also contains a formalization of basic results on operators and their fixpoints in a general setting. All the proofs of the results, presented here, have been checked with the proof assistant Coq. 相似文献
15.
16.
Performance Analysis of Multiuser Detectors for Uplink Quasi-synchronous MC-CDMA Systems 总被引:1,自引:1,他引:1
Felip Riera-Palou Guillem Femenias Jaume Ramis 《Wireless Personal Communications》2007,43(4):1511-1521
This paper analyses and compares the average bit error rate (BER) of different multiuser detectors (MUD) in the uplink of
a multicarrier code- division multiple access (MC-CDMA) system. In particular, maximum likelihood, zero-forcing, minimum mean-square
error and interference cancellation-based multiuser detectors have been analysed for the special case of uncorrelated subcarriers.
The derived BER expressions are based upon previous results on diversity combining and also on recent findings on multiple
input multiple output (MIMO) architectures. The subcarrier correlation is considered in the context of physical parameters
currently under discussion for future wireless systems to give an indication up to what extent the assumption of uncorrelated
subcarrier fading is plausible. 相似文献
17.
Oscar Pedrola Marc Ruiz Luis Velasco Davide Careglio Oscar González de Dios Jaume Comellas 《Computers & Operations Research》2013
In this paper we deal with the survivable internet protocol (IP)/multi-protocol label switching (MPLS)-over-wavelength switched optical network (WSON) multi-layer network optimization problem (SIMNO). This problem entails planning an IP/MPLS network layer over a photonic mesh infrastructure whilst, at the same time, ensuring the highest availability of services and minimizing the capital expenditures (CAPEX) investments. Such a problem is currently identified as an open issue among network operators, and hence, its solution is of great interest. To tackle SIMNO, we first provide an integer linear programming (ILP) formulation which provides an insight into the complexity of its managing. Then, a greedy randomized adaptive search procedure (GRASP) with path-relinking (PR) together with a biased random-key genetic algorithm (BRKGA) are specifically developed to help solve the problem. The performance of both heuristics is exhaustively tested and compared making use of various network and traffic instances. Numerical experiments show the benefits of using GRASP instead of BRKGA when dealing with highly complex network scenarios. Moreover, we verified that the use of GRASP with PR remarkably improves the basic GRASP algorithm, particularly in real-sized, complex scenarios such as those proposed in this paper. 相似文献
18.
Hugo M. Santos Bruno Pedras Abel Tamayo Jaume Casabó Lluis Escriche Berta Covelo José Luis Capelo Carlos Lodeiro 《Inorganic chemistry communications》2009,12(11):1128-1134
Two new emissive chemosensors based on coumarin-343 have been synthesized, and their photophysical studies conducted. L1 contains an aza-thio macrocycle ring as the chelating unit, which has great affinity for soft metal ions, whereas L2 is a parent species without macrocyclic unit. Both compounds were separated by column chromatography and characterized by elemental analysis, 1H,13C NMR, UV–vis and FAB mass spectroscopy. The X-ray structures of L1 and L2 and the supramolecular interactions in the solid state are discussed. Preliminary results on the metal–ion sensing effects of the ligands are presented. Titrations with Ag+, Pd2+ and Ni2+ have been studied by UV–vis absorption and fluorescence spectroscopy. 相似文献
19.
Structural Determinants of the Selectivity of 3‐Benzyluracil‐1‐acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10
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Dr. Francesc X. Ruiz Alexandra Cousido‐Siah Dr. Sergio Porté Dr. Marta Domínguez Isidro Crespo Chris Rechlin Dr. André Mitschler Prof. Dr. Ángel R. de Lera Dr. María Jesús Martín Dr. Jesús Ángel de la Fuente Prof. Dr. Gerhard Klebe Prof. Dr. Xavier Parés Prof. Dr. Jaume Farrés Dr. Alberto Podjarny 《ChemMedChem》2015,10(12):1989-2003
The human enzymes aldose reductase (AR) and AKR1B10 have been thoroughly explored in terms of their roles in diabetes, inflammatory disorders, and cancer. In this study we identified two new lead compounds, 2‐(3‐(4‐chloro‐3‐nitrobenzyl)‐2,4‐dioxo‐3,4‐dihydropyrimidin‐1(2H)‐yl)acetic acid (JF0048, 3 ) and 2‐(2,4‐dioxo‐3‐(2,3,4,5‐tetrabromo‐6‐methoxybenzyl)‐3,4‐dihydropyrimidin‐1(2H)‐yl)acetic acid (JF0049, 4 ), which selectively target these enzymes. Although 3 and 4 share the 3‐benzyluracil‐1‐acetic acid scaffold, they have different substituents in their aryl moieties. Inhibition studies along with thermodynamic and structural characterizations of both enzymes revealed that the chloronitrobenzyl moiety of compound 3 can open the AR specificity pocket but not that of the AKR1B10 cognate. In contrast, the larger atoms at the ortho and/or meta positions of compound 4 prevent the AR specificity pocket from opening due to steric hindrance and provide a tighter fit to the AKR1B10 inhibitor binding pocket, probably enhanced by the displacement of a disordered water molecule trapped in a hydrophobic subpocket, creating an enthalpic signature. Furthermore, this selectivity also occurs in the cell, which enables the development of a more efficient drug design strategy: compound 3 prevents sorbitol accumulation in human retinal ARPE‐19 cells, whereas 4 stops proliferation in human lung cancer NCI‐H460 cells. 相似文献
20.
Cover Picture: Discovery of MK‐8970: An Acetal Carbonate Prodrug of Raltegravir with Enhanced Colonic Absorption (ChemMedChem 2/2015)
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Dr. Abbas M. Walji Dr. Rosa I. Sanchez Dr. Sophie‐Dorothee Clas Dr. Rebecca Nofsinger Dr. Manuel de Lera Ruiz Dr. Jing Li Dr. Amrithraj Bennet Christopher John Dr. David Jonathan Bennett Dr. John M. Sanders Christina N. Di Marco Somang Hope Kim Dr. Jaume Balsells Scott S. Ceglia Dr. Qun Dang Kimberly Manser Becky Nissley Dr. John S. Wai Dr. Michael Hafey Junying Wang Gene Chessen Dr. Allen Templeton Dr. John Higgins Dr. Ronald Smith Dr. Yunhui Wu Dr. Jay Grobler Dr. Paul J. Coleman 《ChemMedChem》2015,10(2):213-213