Recommending multimedia visiting paths in cultural heritage applications

The valorization and promotion of worldwide Cultural Heritage by the adoption of Information and Communication Technologies represent nowadays some of the most important research issues with a large variety of potential applications. This challenge is particularly perceived in the Italian scenario, where the artistic patrimony is one of the most diverse and rich of the world, able to attract millions of visitors every year to monuments, archaeological sites and museums. In this paper, we present a general recommendation framework able to uniformly manage heterogeneous multimedia data coming from several web repositories and to provide context-aware recommendation techniques supporting intelligent multimedia services for the users—i.e. dynamic visiting paths for a given environment. Specific applications of our system within the cultural heritage domain are proposed by means of real case studies in the mobile environment related both to an outdoor and indoor scenario, together with some results on user’s satisfaction and system accuracy.     

Sorafenib delivery nanoplatform based on superparamagnetic iron oxide nanoparticles magnetically targets hepatocellular carcinoma

Currently,sorafenib is the only systemic therapy capable of increasing overall survival of hepatocellular carcinoma patients.Unfortunately,its side effects,particularly its overall toxicity,limit the therapeutic response that can be achieved.Superparamagnetic iron oxide nanoparticles (SPIONs) are very attractive for drug delivery because they can be targeted to specific sites in the body through application of a magnetic field,thus improving intratumoral accumulation and reducing adverse effects.Here,nanoformulations based on polyethylene glycol modified phospholipid micelles,loaded with both SPIONs and sorafenib,were successfully prepared and thoroughly investigated by complementary techniques.This nanovector system provided effective drug delivery,had an average hydrodynamic diameter of about 125 nm,had good stability in aqueous medium,and allowed controlled drug loading.Magnetic analysis allowed accurate determination of the amount of SPIONs embedded in each micelle.An in vitro system was designed to test whether the SPION micelles can be efficiently held using a magnetic field under typical flow conditions found in the human liver.Human hepatocellular carcinoma (HepG2) cells were selected as an in vitro system to evaluate tumor cell targeting efficacy of the superparamagnetic micelles loaded with sorafenib.These experiments demonstrated that this delivery platform is able to enhance sorafenib's antitumor effectiveness by magnetic targeting.The magnetic nanovectors described here represent promising candidates for targeting specific hepatic tumor sites,where selective release of sorafenib can improve its efficacy and safety profile.     

Preface: Volume 16, Issue 2

This volume contains the Proceedings of the fifth EXPRESS workshop. The workshop was held in Nice, France, on 7 September 1998, as a satellite event to CONCUR '98.The EXPRESS workshops aim at bringing together researchers interested in the relations between various formal systems, particularly in the field of Concurrency. More specifically, they focus on the comparison between programming concepts (such as concurrent, functional, imperative, logic and object-oriented programming) and between mathematical models of computation (such as process algebras, Petri nets, event structures, modal logics, rewrite systems etc.) on the basis of their relative expressive power.These workshops were originally held as meetings of the HCM project EXPRESS, which has been active with the same focus from January 1994 till December 1997. The first three workshops were held respectively in Amsterdam (1994, chaired by Frits Vaandrager), Tarquinia (1995, chaired by Rocco de Nicola), and Dagstuhl (1996, chaired by Ursula Goltz, Frits Vaandrager and Rocco de Nicola). The fourth workshop, which took place in Santa Margherita Ligure in 1997 and was co-chaired by Catuscia Palamidessi and Joachim Parrow, was organized as a conference with a call for papers and a significant attendance from outside the project. The fifth workshop, EXPRESS '98, was again organised as a (one day) conference, and was also meant as an occasion to discuss on the inheritance of the Express project and possible directions of future research. We had 17 submissions, out of which we selected 7 for inclusion in these proceedings (41%). Additionally, this collection contains the contribution of the two invited speakers, Matthew Hennessy (University of Sussex, UK) and P.S. Thiagarajan (SPIC Mathematical Institute, IN).We would like to thank the authors of the submitted papers, the invited speakers, and the members of the program committee for their contribution to both the meeting and this volume. We also would like to thank INRIA for their help with the local organization, and Michael Mislove for his help with the editing of the proceedings.

EXPRESS '98 Programme Committee
Ilaria Castellani (co-chair, INRIA)	Catuscia Palamidessi (co-chair, PSU)
Luca Aceto (Aalborg Univ.)	Roberto Amadio (Univ. Marseille)
Eike Best (Oldenburg Univ.)	Steve Brookes (CMU)
Philippe Darondeau (INRIA)	Rocco De Nicola (Univ. Firenze)
Jan Willem Klop (CWI)	Patrick Lincoln (SRI)
Frits Vaandrager (Nijmegen Univ.)	Glynn Winskel (Aarhus Univ.)

Full-size table

17 October 1998, Ilaria Castellani and Catuscia Palamidessi     

Knowledge Management in Locating the Patient in an Emergency Medical Service in Italy

This study examines an Emergency Medical Service in order to analyze the composite set of activities and instruments directed at locating the patient. The good management of information about the location of the emergency is highly relevant for a reliable rescue service, but this information depends on knowledge of the territory that is socially distributed between EMS operators and callers. Accordingly, the decision-making process often has to go beyond the emergency service protocols, engaging the operator in undertaking an open negotiation in order to transform the caller’s role from layman to “co-worker”. The patient’s location turns out to be an emerging phenomenon, collaborative work based on knowledge management involving two communities—the callers and the EMS operators—that overlap partially. Drawing examples from emergency calls, the study analyzes the practice of locating a patient as a complex and multi-layered process, highlighting the role played by new and old technologies (the information system and the paper maps) in this activity. We argue that CSCW technologies enable the blended use of different kinds of instruments and support an original interconnection between the professional localization systems and the public’s way of defining a position.     

Self-adaptation and secure information flow in multiparty communications

We present a comprehensive model of structured communications in which self-adaptation and security concerns are jointly addressed. More specifically, we propose a model of multiparty, self-adaptive communications with access control and secure information flow guarantees. In our model, multiparty protocols (choreographies) are described as global types; security violations occur when process implementations of protocol participants attempt to read or write messages of inappropriate security levels within directed exchanges. Such violations trigger adaptation mechanisms that prevent the violations to occur and/or to propagate their effect in the choreography. Our model is equipped with local and global adaptation mechanisms for reacting to security violations of different gravity; type soundness results ensure that the overall multiparty protocol is still correctly executed while the system adapts itself to preserve the participants’ security.     

Light on! Real world evaluation of a P300-based brain-computer interface (BCI) for environment control in a smart home

Brain-computer interface (BCI) systems aim to enable interaction with other people and the environment without muscular activation by the exploitation of changes in brain signals due to the execution of cognitive tasks. In this context, the visual P300 potential appears suited to control smart homes through BCI spellers. The aim of this work is to evaluate whether the widely used character-speller is more sustainable than an icon-based one, designed to operate smart home environment or to communicate moods and needs. Nine subjects with neurodegenerative diseases and no BCI experience used both speller types in a real smart home environment. User experience during BCI tasks was evaluated recording concurrent physiological signals. Usability was assessed for each speller type immediately after use. Classification accuracy was lower for the icon-speller, which was also more attention demanding. However, in subjective evaluations, the effect of a real feedback partially counterbalanced the difficulty in BCI use. PRACTITIONER SUMMARY: Since inclusive BCIs require to consider interface sustainability, we evaluated different ergonomic aspects of the interaction of disabled users with a character-speller (goal: word spelling) and an icon-speller (goal: operating a real smart home). We found the first one as more sustainable in terms of accuracy and cognitive effort.     

Effect of geometry and green density on the anisotropic sintering shrinkage of axisymmetric iron parts

Sintering shrinkage of prior cold compacted iron rings with different geometry (height to wall thickness ratio) and green density in the 6.5–7.3?g/cm³ range was investigated. It displays a minimum at an intermediate green density. Axial, tangential and radial shrinkages are different, due to the gradients of green density along the axial and the radial directions. Therefore, the effect of height on shrinkage and its anisotropy is the result of their effect on the stress distribution in the green parts during cold compaction, and the resulting green density and deformation experienced by the powder. Anisotropy decreases on increasing shrinkage.     

From experimental data,the mechanics relationships describing the behaviour of four different low alloyed steel powders during uniaxial cold compaction

This work aims at determining the constitutive model of four commercial water atomised low alloyed steel powders during cold compaction. Single-action experiments were performed, obtaining cylindrical specimens with different H/D ratios. The distribution of axial and radial stresses was investigated, and the relationships describing both the radial stress transmission coefficient and the flow stress as functions of the relative density were determined. The radial stress transmission coefficient also confirmed the hypothesised value of Poisson’s coefficient. The friction coefficient between the powder column and the die wall was determined, also highlighting the influence of the H/D ratio. Measuring the axial and radial strains due to spring-back, the axial and radial elastic moduli were determined, as functions of the relative density. The results obtained for the four materials were compared, also highlighting both differences and similarities.     

A DNA Methyltransferase Modulator Inspired by Peyssonenyne Natural Product Structures

A novel epigenetic modulator that displays a DNMT1 inhibition and DNMT3A activation profile was characterized (compound 8 ). This compound is a derivative of palmitic acid that incorporates the putative reactive functional group (diynone) of the peyssonenyne natural products. Other analogues containing the diynone or an acetoxyenediyne did not show the same biological profile. In U937 human leukemia cells, diynone 8 induced cell differentiation and apoptosis, which correlated with the expression of Fas protein. Very surprisingly, diynone 8 was toxic to normal human fibroblasts (BJ) and mouse embryo fibroblasts (MEF), but not to immortalized human fibroblasts (BJEL); this unique effect was not observed with the classical DNMT inhibitor 5‐azacytidine. Therefore, compound 8 interferes in a very specific manner with signaling pathways, the activities of which differ between normal and immortalized cell types. This toxicity is reminiscent of the effects of Dnmt1 ablation on mouse fibroblasts. In fact, some of the genes deregulated by the loss of Dnmt1 are similarly deregulated by 8 , but not by the DNMT inhibitor SGI‐1027.     

Biohybrid Bovine Bone Matrix for Controlled Release of Mesenchymal Stem/Stromal Cell Lyosecretome: A Device for Bone Regeneration

SmartBone^® (SB) is a biohybrid bone substitute advantageously proposed as a class III medical device for bone regeneration in reconstructive surgeries (oral, maxillofacial, orthopedic, and oncology). In the present study, a new strategy to improve SB osteoinductivity was developed. SB scaffolds were loaded with lyosecretome, a freeze-dried formulation of mesenchymal stem cell (MSC)-secretome, containing proteins and extracellular vesicles (EVs). Lyosecretome-loaded SB scaffolds (SBlyo) were prepared using an absorption method. A burst release of proteins and EVs (38% and 50% after 30 min, respectively) was observed, and then proteins were released more slowly with respect to EVs, most likely because they more strongly adsorbed onto the SB surface. In vitro tests were conducted using adipose tissue-derived stromal vascular fraction (SVF) plated on SB or SBlyo. After 14 days, significant cell proliferation improvement was observed on SBlyo with respect to SB, where cells filled the cavities between the native trabeculae. On SB, on the other hand, the process was still present, but tissue formation was less organized at 60 days. On both scaffolds, cells differentiated into osteoblasts and were able to mineralize after 60 days. Nonetheless, SBlyo showed a higher expression of osteoblast markers and a higher quantity of newly formed trabeculae than SB alone. The quantification analysis of the newly formed mineralized tissue and the immunohistochemical studies demonstrated that SBlyo induces bone formation more effectively. This osteoinductive effect is likely due to the osteogenic factors present in the lyosecretome, such as fibronectin, alpha-2-macroglobulin, apolipoprotein A, and TGF-β.