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121.
Jin-Young Kim Seong-Cheol Park Indeok Hwang Hyeonsook Cheong Jae-Woon Nah Kyung-Soo Hahm Yoonkyung Park 《International journal of molecular sciences》2009,10(6):2860-2872
Antimicrobial proteins (peptides) are known to play important roles in the innate host defense mechanisms of most living organisms, including plants, insects, amphibians and mammals. They are also known to possess potent antibiotic activity against bacteria, fungi, and even certain viruses. Recently, the rapid emergence of microbial pathogens that are resistant to currently available antibiotics has triggered considerable interest in the isolation and investigation of the mode of action of antimicrobial proteins (peptides). Plants produce a variety of proteins (peptides) that are involved in the defense against pathogens and invading organisms, including ribosome-inactivating proteins, lectins, protease inhibitors and antifungal peptides (proteins). Specially, the protease inhibitors can inhibit aspartic, serine and cysteine proteinases. Increased levels of trypsin and chymotrypsin inhibitors correlated with the plants resistance to the pathogen. Usually, the purification of antimicrobial proteins (peptides) with protease inhibitor activity was accomplished by salt-extraction, ultrafiltration and C18 reverse phase chromatography, successfully. We discuss the relation between antimicrobial and anti-protease activity in this review. Protease inhibitors from plants potently inhibited the growth of a variety of pathogenic bacterial and fungal strains and are therefore excellent candidates for use as the lead compounds for the development of novel antimicrobial agents. 相似文献
122.
Drug release from nanoparticles of Poly(DL-lactide-co-glycolide) 总被引:1,自引:0,他引:1
Nanoparticles of poly(DL-lactide-co-glycolide) (PLGA) were prepared by dialysis method without surfactant. The size of PLGA
nanoparticles prepared from dimethylacetamide (DMAc), dimethylformamide (DMF), and dimethylsulfoxide (DMSO) as an initial
solvent was smaller than that of acetone or 1,4-dioxane. Selected initial solvent used to dissolve the copolymer significantly
affects the size of nanoparticles. Also, the size of PLGA nanoparticles was changed according to the copolymer composition.
It was shown that PLGA nanoparticles have spherical shapes from the results of scanning electron microscope (SEM) and transmission
electron microscope (TEM) observations. From these results was shown the potential that the PLGA nanoparticles could be formed
successively by dialysis method without surfactant. The drug-loading contents were also dependent on the copolymer composition
and initial feeding amount of the drug. The greater lactide ratio on the copolymer composition led to higher drug loading
contents. Also, the higher the initial feeding amount of drug, the higher the drug loading contents. Clonazepam (CNZ) was
used as a model drug. CNZ was slowly released in higher lactide ratio in the copolymer composition and in the higher drug
loading contents. 相似文献
123.
Jin‐Sek Do Baoku Zhu Sang Hyup Han Changwoon Nah Myong‐Hoon Lee 《Polymer International》2004,53(8):1040-1046
A novel approach to prepare a polyimide nanofoam was explored by using a polyimide precursor grafted with a labile poly(propylene glycol) (PPG) oligomer. The PPG‐grafted polyimide precursor, poly((amic acid)‐co‐(amic ester)), was synthesized via partial esterification of poly(amic acid) derived from pyromellitic dianhydride (PMDA) and 4,4′‐oxydianiline (ODA) with bromo‐terminated poly(propylene glycol) in the presence of K2CO3 in hexamethylphosphoramide and N‐methylpyrrolidone. The precursor polymer film was spin‐coated onto a glass substrate, then imidized at 200 °C under nitrogen, and subsequently the PPG graft was decomposed by heating the film at 300 °C for 9 h in air, resulting in the PMDA/ODA polyimide nanofoam. The precursor polymers, polyimides and foamed polyimides were characterized by a variety of techniques including 1H‐NMR spectroscopy, Fourier‐transform infrared (FT‐IR) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The homogeneously distributed nano‐sized pores of 20–40 nm were observed by transmission electron microscopy (TEM) of the foamed polyimide. Copyright © 2004 Society of Chemical Industry 相似文献
124.
Changwoon Nah Jee Young Lim Rajatendu Sengupta Baik Hwan Cho Alan N Gent 《Polymer International》2011,60(1):42-44
The interactions of carbon nanotubes (CNTs) and carbon black (CB) with rubber matrices are of great interest. Although both belong to the carbon filler family, their interactions are different. In this study the adhesion of CNTs, if any, with natural rubber (NR) was examined. Scanning electron microscopy examinations made on cryogenically fractured surfaces of a crosslinked NR sample containing 7% by weight of CNTs showed that the CNT bundles emerged from the side surface (narrowed by Poisson's ratio) and slowly slid back in when the deformation was removed. The protruded lengths were many times larger than the nanotube bundle diameters. This extensive slipping out of CNTs from the rubber matrix suggests that interfacial interactions between CNTs and NR are quite weak. In contrast, relatively strong interactions were found between CB and rubber, indicated by the large amount of bound rubber formation. Reinforcement of rubber by CNTs is therefore attributed to the large aspect ratio of CNT bundles. Physical entanglement with rubber molecules is then able to generate effective load transfer, replacing the strong adhesion found with CB. Copyright © 2010 Society of Chemical Industry 相似文献
125.
Encapsulation of solvent during cure is proposed as one way to alter the network topology of crosslinked polymers. We performed all-atom molecular dynamics simulations to study systems comprised of Epon828 epoxy resin and Jeffamine-D400 diamine crosslinkers cured with varying amounts of the inert solvent dichloromethane (0–50 wt%) and then dried and annealed. Densities, glass transition temperatures, and Young's moduli are observed to be insensitive to the initial amount of dichloromethane. These findings were verified by experiment. Simulations also showed that radial distribution functions and dihedral angle distributions were insensitive to the amount of dichloromethane present. However, using Dijkstra's algorithm, we observed that the distribution of minimum path lengths between crosslinks shifts appreciably to larger values as the amount of dichloromethane increases. This suggests that solvent-encapsulated curing can allow for control over network topology without changing crosslink density or intermolecular packing, and the properties derived from it, in highly crosslinked polymers. 相似文献
126.
The clamping force of a high-strength bolt reduces within a certain time period after the initial clamping force. When special
treatments are used on a faying surface, the clamping force is relaxed severely. Tests were conducted for slip critical joints
subjected to various faying surface parameters. Relaxation occurred for slip resistant joints with an uncoated surface that
had been shot-blasted, cleaned, milled or rusted. It was observed that the initial clamping force dropped from 6.2% to 8.0%
after 744 hours. For joints with a 5 mil thick zinc coating, the clamping force of the bolts decreased by 8.37%, and in the
case of 4.9 mil thick red lead painted treatment, the relaxation ratio was 24.6%. The standard deviation of the slip coefficients
between the time immediately after tightening and 1,000 hours after tightening was 0.223. It is particularly noteworthy that,
for red lead painted treatment, the slip coefficient dropped from 2.5 times to 2.8 times when compared with the slip coefficient
before relaxation. Joints with inorganic zinc should not have thickness exceeding 5 mils, and joints with a red lead painted
surface should not be allowed regardless of the thickness of coating. 相似文献
127.
128.
Preparation of waterborne polyurethanes using an amphiphilic diol for breathable waterproof textile coatings 总被引:2,自引:0,他引:2
Qing Bo Meng Sung-Il Lee Changwoon Nah Youn-Sik Lee 《Progress in Organic Coatings》2009,66(4):382-386
The application of polyurethanes (PUs) on breathable waterproof fabric coatings requires a balance of water vapor permeability (WVP) and water resistance which can be achieved by tailoring hydrophilic and hydrophobic segments. PU prepolymers were prepared from isophorone diisocyanate, dimethylol butanoic acid, and a mixture of various ratios of amphiphilic PPG2050 (copolymer of ethylene oxide and propylene oxide with –OH end groups) and hydrophobic poly(tetramethylene ether glycol) (PTMEG). After neutralization with triethylamine, the prepolymers were chain-extended with ethylene diamine/1,4-butanediol (1:1 by molar). The WVP values of the fabric coatings prepared using various waterborne PUs were very similar (910–990 g/m2 × 24 h). When waterborne PUs prepared using a mixture of PPG2050 and PTMEG were employed for the textile coatings, the resulting PU-coated textiles exhibited excellent waterproof properties (>10,000 mm H2O). The textile coatings prepared from PPG2050/PTMEG-based waterborne PUs were significantly more waterproof than those prepared from poly(ethylene glycol) (PEG)/poly(propylene glycol) (PPG)/PTMEG-based waterborne PU. This is probably due to a more even distribution of hydrophobic segments in the PUs, even though the WVP values of the PEG/PPG/PTMEG-based PU coatings were considerably smaller than those of the PPG2050/PTMEG-based PU coatings. 相似文献
129.
Lim I Yoon SJ Lee W Nah YC Shrestha NK Ahn H Han SH 《ACS applied materials & interfaces》2012,4(2):838-841
A thin film of iodine doped polythiophene was grown photoelectrochemically around the dye-sensitized TiO(2) nanoparticles in a Gr?tzel cell, and the effect of iodine doping level on the cell performance was investigated using X-ray photoelectron spectroscopy, electrochemical impedance spectroscopy, and photovoltage decay. At an optimum doping level, the cell demonstrated the enhanced energy conversion efficiency by 27.52% compared to the cell without polythiophene. 相似文献
130.
Seungahn Nah Aaron S. Veenstra Dhavan V. Shah 《Journal of Computer-Mediated Communication》2006,12(1):230-247
This case study examines how traditional and Internet news use, as well as face‐to‐face and online political discussion, contributed to political participation during the period leading up to the Iraq War. A Web‐based survey of political dissenters (N = 307) conducted at the start of the U.S.‐led invasion of Iraq provides the data used to examine the relationships among informational media use, online and face‐to‐face political discussion, and political participation among the respondents, who were recruited through blogs, discussion boards, and listservs opposing the Iraq war. Analyses reveal that among these respondents, Internet news use contributed to both face‐to‐face and online discussion about the situation in Iraq. Online and face‐to‐face political discussion mediated certain news media effects on anti‐war political participation. The study stresses the complementary role of Web news use and online political discussion relative to traditional modes of political communication in spurring political participation. 相似文献