排序方式: 共有62条查询结果,搜索用时 15 毫秒
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CD1c presentation of synthetic glycolipid antigens with foreign alkyl branching motifs 总被引:1,自引:0,他引:1
de Jong A Arce EC Cheng TY van Summeren RP Feringa BL Dudkin V Crich D Matsunaga I Minnaard AJ Moody DB 《Chemistry & biology》2007,14(11):1232-1242
Human CD1c is a protein that activates alphabeta T cells by presenting self antigens, synthetic mannosyl phosphodolichols, and mycobacterial mannosyl phosphopolyketides. To determine which molecular features of antigen structure confer a T cell response, we measured activation by structurally divergent Mycobacterium tuberculosis mannosyl-beta1-phosphomycoketides and synthetic analogs with either stereorandom or stereospecific methyl branching patterns. T cell responses required both a phosphate and a beta-linked mannose unit, and they showed preference for C(30-34) lipid units with methyl branches in the S-configuration. Thus, T cell responses were strongest for synthetic compounds that mimicked the natural branched lipids produced by mycobacterial polyketide synthase 12. Incorporation of methylmalonate to form branched lipids is a common bacterial lipid-synthesis pathway that is absent in vertebrates. Therefore, the preferential recognition of branched lipids may represent a new lipid-based pathogen-associated molecular pattern. 相似文献
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Elbeshary A. A. Mohammed Michel De Keersmaecker Kim Verbeken Annemie Adriaens 《Journal of Solid State Electrochemistry》2017,21(3):693-704
In this study, sodium salts of saturated linear carboxylic acids with the general formula CH3(CH2) n?2COONa (n = 14, 18)—labeled NaC14 and NaC18—were used to inhibit the corrosion of metallic lead via the development of protective coatings for lead heritage objects. The salts were dissolved in water/ethanol 1:1 (V/V) mixture at 50 °C to increase their solubility, and the coatings were formed by immersing lead samples in the resulted solutions for 24 h. The coatings were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. A hydrophobic layer of lead carboxylates appeared to form on the metal surface, and its corrosion inhibition properties were examined by linear sweep voltammetry and electrochemical impedance spectroscopy in a corrosive solution simulating the environment of museums with uncontrolled conditions. The lead carboxylates formed a protective barrier that inhibited further lead corrosion. 相似文献
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The magnetic properties of electrical steel such as magnetization curves, magnetization behavior and specific magnetic losses are related to the microstructure and the texture of the steel. A quantitative model, which describes the effect of microstructure and texture and their interplay on the magnetic losses P, is still missing. Based on experimental data for nonoriented electrical steels and FeSi-samples with high (Si, Al)-content, a more general formula is proposed for the dependence of P, at a given value of magnetic induction B, as a function of the mean value of the grain size d of the material and of the intensities of the relevant magnetic texture components. 相似文献
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Radionuclides have shown to be effective in tumour therapy. However, the side effects determine the maximum deliverable dose. Recently, it has been demonstrated that cells can be permeabilised through sonoporation using ultrasound and contrast microbubbles. The use of sonoporation in treatment of tumours may increase the anti-tumour efficacy of radionuclide treatment. The mechanisms as well as the effects sonoporation in tumour treatment strategies are still not understood. The purpose of this study is to determine the effects of ultrasound and contrast microbubbles on the internalisation of the radionuclide (111)In-DOTA-Tyr(3)-octreotate in tumour cells. To optimize ultrasound settings for ultrasound adjunctive tumour therapy we incubated rat pancreatic CA20948 tumour cells with two dyes (MW 40 and 70 kDa). The uptake levels were compared with cells treated with ultrasound and contrast microbubbles for different ultrasound settings. The highest molecular uptake was found with addition of contrast microbubbles (ratio of 10 bubbles to 1 cell) and with the ultrasound setting: duty cycle 0.013%, mechanical index (MI) 0.42, and treatment times of 30 and 60 min. These settings were used to enhance the internalisation of (111)In-DOTA-Tyr(3)-octreotate. We found a 160% higher internalisation of (111)In-DOTA-Tyr(3)-octreotate by tumour cells adjunctively treated with ultrasound and contrast microbubbles compared to untreated cells. These results show that adjunctive tumour treatment with the radionuclide (111)In-DOTA-Tyr(3)-octreotate and ultrasound contrast microbubbles may be feasible. When using adjunctive ultrasound contrast microbubble treatment, a lower radionuclide doses are required to reach the same anti-tumour effect. 相似文献
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Annemieke Janssen Yifeng Shi Prof. Younan Xia 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(61):13890-13895
In order to maximize the performance of nanocrystals in a specific application, it is necessary to control both their size and shape. Here we report a one-pot protocol that allows us to separate growth from nucleation for achieving better control over the size and shape of Pd nanocrystals. The two processes are temporally separated from each other, although the synthesis is carried out in the same reaction container. Size control is achieved by simply varying the ratio between the amounts of precursor allocated to the growth and nucleation processes. With the involvement of seeds at a fixed number, increasing the amount of precursor for growth leads to increasingly larger nanocrystals. Shape control is made possible by varying the capping agent, with bromide leading to a cubic shape and citrate inducing the formation of an octahedral shape. The synthesis can also be scaled up by at least tenfold without compromising the quality. 相似文献
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van den Berg AW Flikkema E Lems S Bromley ST Jansen JC 《The journal of physical chemistry. B》2006,110(1):501-506
The anisotropic self-diffusion of molecular hydrogen in the multiple cage clathrasil losod (LOS) is modeled by means of molecular dynamics (MD) simulations of up to 1 micros for the temperature range 900-1200 K while treating the framework as fully flexible. The LOS diffusion tensor is calculated employing an analytical method based on hopping rates. The diffusion in the c-direction of the unit cell is found to be approximately two times more rapid than in the a- and the b-directions, a characteristic of importance for the application of LOS as a membrane. The overall diffusion is based on five different hop types for which the individual hopping rates and diffusion barriers are calculated separately. We show explicitly that the shape and volume of the cages have a significant effect on the hopping rates and further that even small deformations of the circular Si6O6 apertures have a large influence on the energetic barrier for hydrogen diffusion. Compared to the single cage clathrasils dodecasil 3C (MTN) and sodalite (SOD), LOS has a lower diffusion rate. However, from a technical point of view this rate (at 573 K) is still fast enough for LOS to be interesting as a size-selective membrane or as a hydrogen-adsorption medium. 相似文献
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A new biocompatible strategy for photoinduced DNA interstrand cross-linking is presented. Methylene blue induced (1)O(2) formation triggers furan oxidation; the resulting aldehyde then rapidly reacts with complementary A or C with formation of stable adducts. Easily accessible furan modified nucleosides, a commercially available photosensitizer, and visible light irradiation constitute the necessary tools to achieve selective duplex interstrand cross-linking. 相似文献