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??Efficacy of FOLFOX4 regimen systemic chemotherapy in treating advanced hepatocellular carcinoma: An analysis of 22 cases YIN Xiao-yu*??CHEN Jie??PENG Jian-xin??et al. *Department of Hepatobiliary Surgery??the First Affiliated Hospital of Sun Yat-sen University??Guangzhou 510080??China
Corresponding author??YIN Xiao-yu??E-mail??yinxy@21cn.com
Abstract Objective To evaluate the efficacy of FOLFOX4 regimen systemic chemotherapy in treating advanced hepatocellular carcinoma (HCC). Methods The clinical data of 22 cases of advanced HCC were treated by FOLFOX4 regimen systemic chemotherapy between July 2007 and July 2013 in the First Affiliated Hospital of Sun Yat-sen University were analyzed retrospectively. The chemotherapy was given each two weeks??with a maximum of 8 cycles. The therapeutic responses were evaluated each 3 cycles and end of treatment. Results A total of 85 cycles were administered in 22 cases??with a mean of ??3.7±2.0?? cycles /case. There were no complete response??5 partial responses??5 static diseases and 12 progressive diseases. The objective response rate was 22.7% (5/22)??and disease control rate was 45.4% (10/22)??with a one-year survival rate of 12.1% and median survival time of 5.8 months in the follow up of 2-34 ??8.5±1.9??months . In 10 cases of disease control after chemotherapy??the median survival time reached up to 9.5 months. Conclusion FOLFOX4 regimen systemic chemotherapy is effective in part of advanced HCC??and represented as an effective modality.     

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??Abstract?? Objective To study balloon dilatation with cryotherapy under bronchoscope for subglottic stenosis in infants and young children??and to explore the efficacy of this new technology??the timing of treatment and safety. MethodFrom July 2009 to May 2014 in 28 SGS cases aged from 1 month to 3 years?? bronchoscopic balloon dilatation treatment with CO2 cryotherapy was performed?? and different types of SGS treated by minimal invasi were assessed regarding efficacy, complications and outcome. Results The infant SGS were divided into ??°~??° by severity?? and soft membrane SGS and scarring SGS by the causes of stenosis. ??° SGS included 16 cases, in which 8 cases soft membrane SGS were treated by balloon dilatation effectively?? 9 cases after combined treatment; in scarring SGS balloon dilatation was effective in 1 case?? 4 cases after combined therapy; ??° SGS included 8 cases?? soft membrane SGS were treated effectively in 2 cases?? 4 cases after combined treatment; in scarring SGS balloon dilatation was effective in 1 case?? 2 cases after combined therapy; ?? °SGS included 4 cases?? 1 case of soft membrane SGS and 1 case of scarring SGS responded well to integrated treatment .Conclusion MSCT and bronchoscopy assessment is used in grading the extent and causes of stratification in infants with subglottic stenosis?? and then we can select the appropriate treatment programs to improve the prognosis of the disease and improve life quality of SGS children.     

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??Abstract??The purpose of the present study was to show the different choices of periodontal surgeries in resolving various clinical problems. There were both demands of restoration in bilateral posterior areas of the patient??but their remaining of local dental tissue was different. In order to immediately restore the function and esthetic of the patient's dentition??the crown-lengthening surgery was applied on the side of more dental tissue available??the tooth was extracted on the other side of less dental tissue available and cureless apical lesion??also??implant surgery was applied electively. Soft and hard tissue augmentation was finished in implantation synchronously. The effect of final restorations was good and the patient was satisfied. The periodontal surgery played the key role in multidisciplinary treatment??therefore??its indications should be carefully and comprehensively chosen in overall treatment design.     

CXCL12/CXCR4信号通路与缺血性脑卒中新进展

缺血性脑卒中是一种严重威胁人类健康和生命的疾病,致残率和致死率较高。缺血性脑卒中会导致中枢神经系统损伤和功能障碍。缺血性脑卒中发生后,内皮祖细胞参与修复血管内皮和神经损伤,在这一过程中CXCL12/CXCR4 信号通路起着重要的作用。本文将对CXCL12/CXCR4 信号通路与缺血性脑卒中新进展进行综述。     

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??Objective    To explore the relationship between chronic periodontitis and cytokine interleukin-8 ??IL-8?? by literature review. Methods    The CNKI??Wanfang database??PubMed retrieval platform and Embase database were searched by computer. The research papers on the level of interleukin-8 in chronic periodontitis were collected. The retrieval time was up to 2016??screen literature according to the inclusion and exclusion criteria??use Stata12.0 software for meta analysis. Results    The level of IL-8 in gingival crevicular fluid in patients with chronic periodontitis was significantly higher than that in normal controls??P??0.05??. In the Asian population?? the level of IL-8 in gingival crevicular fluid in patients with chronic periodontitis was higher than that in normal controls??P??0.05??. In the western population??there was no difference in the level of IL-8 in gingival crevicular fluid between patients with chronic periodontitis and normal controls??P??0.05??. Conclusion    There is a significant difference in chemokines interleukin-8 between patients with chronic periodontitis and normal controls in the Asian population. Chemokines interleukin-8 may increase the risk of chronic periodontitis.     

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??Case analysis of conversion therapy by laparoscopic HIPEC combined with intraperitoneal and systemic chemotherapy for gastric cancer peritoneal metastasis XUE Kan*??LI Zi-yu??LI Shuang-xi??et al. * Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China
Corresponding author??LI Zi-yu??E-mail??ligregory@outlook.com
Abstract Objective To investigate the efficacy of laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) combined intraperitoneal and systemic chemotherapy in gastric cancer patients with peritoneal metastasis. Methods A gastric cancer patient whose peritoneal cancer index was 39 during laparoscopic exploration was admitted at Peking University Cancer Hospital Gastrointestinal Center. The patient received laparoscopic HIPEC with docetaxel, followed by 6 courses of intraperitoneal and intravenous PTX??along with S-1 orally. Results CT scan showed distinct response during post-treatment evaluation. A second look by laparoscopy was suggested by MDT. No tumor cell was found in the lavage fluid through abdominocentesis and no metastasis can be seen by laparoscopic exploration. Then total gastrectomy plus D2 minus No.10 lymph node dissection was performed. The patient recovered smoothly after surgery. The pathology confirmed a ypT3N2M1, moderate to poor-differentiated adenocarcinoma, from gastric antrum to body. By September 2017, the patient was still in postoperative treatment. Conclusion Laparoscopic HIPEC combined with intraperitoneal and systemic chemotherapy showed effective interim results in gastric cancer peritoneal metastasis conversion therapy and is deserved for further researches.     

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??Value of preoperative lymphoscintigraphy in sentinel lymph node biopsy of breast cancer SUN Xiao*, LIU Juan-juan, WANG Yong-sheng, et al. *Breast Cancer Center, Shandong Cancer Hospital, Jinan 250117, China
Correcponding author: WANG Yong-sheng, E-mail: wangysh2008@yahoo.com.cn
Abstract Objectives Background Although preoperative lymphoscintigraphy for sentinel lymph nodes biopsy (SLNB) in breast cancer patients is undergone commonly, its clinical significance remains controversial. Methods Firstly, a database containing 716 consecutive breast cancer patients who received preoperative lymphoscintigraphy before SLNB was retrospectively analyzed. Secondly, 565 consecutive breast cancer patients were prospectively randomized into groups with or without preoperative lymphoscintigraphy before SLNB. Results In the retrospective study, sentinel lymph nodes (SLNs) were well imaged by lymphoscintigraphy in 86.6% patients, and negative lymphoscintigraphy results were associated with axillary node metastases. Failure of identification of SLNs by isotope alone was associated with whether axillary hot spot was imaged by lymphoscintigram (P<0.001). There were no significant differences in the false negative rate (P=0.731) of SLNB by isotope alone, in the identification rate (P=0.174) and the false negative rate (P=0.947) of SLNB by combination of dye and isotope between patients who had axillary hot spot in lymphoscintigram and those who had not. In the prospective study, 290 patients were randomized into the group with preoperative lymphoscintigraphy (82.1% patients were well imaged by lymphoscintigraphy) and 275 patients without. There were no significant differences between two groups in the identification rate (P=0.757) and the false negative rate (P=1.00) of SLNB by isotope alone, also in the identification rate (P=1.00) and the false negative rate (P=1.00) of SLNB by combination of dye and isotope. Conclusion Preoperative lymphoscintigraphy could not improve the identification rate and reduce the false negative rate of SLNB in breast cancer patients, and it is not a prerequisite for SLNB.