下肢动脉闭塞性病变的64层CT血管造影与DSA的对照研究

目的对照DSA,研究64层螺旋CT血管造影(CTA)对下肢动脉闭塞性病变诊断的临床应用价值。方法对31例下肢动脉闭塞性病变患者行64层螺旋CTA检查,检查后2周内行DSA。CT数据重建采用最大密度投影、容积重建及多平面重建技术。DSA采用步进跟踪造影技术或分段DSA进行下肢血管检查,将CTA与DSA结果比较。结果在216个动脉节段中,2种检查方法狭窄程度显示一致的有157个,被CTA高估13个,低估6个。CTA对下肢动脉狭窄程度≥50%诊断的灵敏度为98.21%,特异度96.15%,准确率97.22%,阳性预测值96.49%,阴性预测值98.04%。结论64层CT血管造影是下肢动脉闭塞性病变评估的可靠方法,可为制订介入治疗方案提供准确的参考依据。     

64层螺旋CT冠状动脉成像与冠状动脉造影的对比研究

目的 评价64层螺旋CT冠状动脉造影对冠状动脉疾病的临床诊断价值.方法 59例临床诊断或可疑冠心病患者行64层螺旋CT冠状动脉成像检查,并以冠状动脉造影结果作为对照,分段评价结果,冠状动脉狭窄≥50%为阳性病变.分析64层螺旋CT冠状动脉血管成像(CTA)诊断冠状动脉狭窄的敏感性、特异性、阳性预测值及阴性预测值.结果 共评价741段冠状动脉,64层螺旋CT冠状动脉血管成像用于诊断冠心病的敏感性、特异性、阳性预测值、阴性预测值分别为58.8%、97.7%、76.9%、94.8%.结论 64层螺旋CT冠状动脉血管成像有较高的诊断准确性,可以作为评价冠状动脉狭窄的一种无创检查方法.     

16层螺旋CT冠状动脉成像与DSA的对照研究

目的: 评价16层螺旋CT冠状动脉成像在冠状动脉狭窄中的临床应用价值,以及不同性质的斑块对管腔狭窄评价的影响。方法:38例患者同时行16层螺旋CT冠状动脉成像和传统冠状动脉造影DSA(CAG)检查,以CAG为“金标准”,将二者进行对照。结果:16层螺旋CT判断冠状动脉轻度、中度及高度狭窄的灵敏度、特异度、阳性预测值、阴性预测值分别为72.7%、38.5%、50%、62.5%;82.4%、72.7%、70%、84.2%;85%、90.5%、81%、92.7%。随着冠脉狭窄程度的增加,16层CT对其诊断价值增高。严重钙化、中度钙化及未钙化斑块对冠脉中度及中度以上狭窄评价的灵敏度、特异度、阳性预测值、阴性预测值分别为 73. 3%、22. 2%、61. 1%、33. 3%; 70%、55. 6%、63. 6%、62. 5%; 93. 8%、85. 7%、93.8%、85.7%。16层螺旋CT对管壁钙化的冠脉狭窄程度的评价仍有局限性,钙化程度越重,对管腔狭窄的评价困难越大,而对未钙化斑块的评价有较高价值。结论:16 层螺旋 CT冠状动脉成像是一种简便易行、安全可靠的无创性检查方法,可作为冠心病的筛选手段和冠脉术前评价和术后复查的首选方法。     

64层螺旋CT冠状动脉造影评价冠状动脉支架再狭窄

目的 探讨64层螺旋CT冠状动脉造影对冠状动脉支架再狭窄评价的准确性.方法 采用西门子SOMATOM SENSATION CARDIAC 64层螺旋CT对59例冠脉支架植入后患者(共计112枚支架)行CT冠状动脉造影,以冠状动脉造影结果为金标准,分析检测的灵敏度、特异度等指标.结果 64层螺旋CT显示植入的112枚支架中109枚支架内腔得到清晰显示,总显示率97.3%(109/112).12处中、重度狭窄,多层螺旋CT冠状动脉造影诊断正确10处;15处轻度狭窄,多层螺旋CT冠状动脉造影正确5处,误诊10处,无漏诊.再狭窄诊断的灵敏度83.3%(10/12),特异度99%(99/100),阳性预测值90.9%(16/24),阴性预测值98%(99/101),准确率97.3%(109/112).结论 64层螺旋CT对冠状动脉支架再狭窄诊断有较高的准确性,可作为一种无创性检查用于支架术后的随访.     

钙化斑块对MSCTA诊断糖尿病足下肢血管病变的影响

目的探讨钙化斑块对16层螺旋CT血管成像(MSCTA)诊断糖尿病足病人下肢血管狭窄程度的影响。资料与方法收集同时行16层螺旋CT血管成像及数字减影血管造影(DSA)检查的糖尿病足病人35例,计38侧下肢动脉,每侧下肢分为15段,将狭窄程度分为正常、轻度、中度、重度、闭塞。根据MSCTA横断而影像将血管钙化程度分为无钙化、轻度、中度、重度钙化。以DSA为金标准,分别计算严重钙化节段与非严重钙化节段MSCTA诊断膝上及膝下动脉血管狭窄的敏感度、特异度、准确度、约登指数、阳性预测值、阴性预测值,采用Kappa检验进行MSCTA与DSA的一致性判定。结果以DSA为金标准,MSCTA评估膝上动脉非严重钙化节段和严重钙化节段血管狭窄≥50%的敏感度、特异度、准确度、约登指数、阳性预测值、阴性预测值分别为97.1%、98.7%、98.2%、95.8%、97.0%、98.7%和96.3%、93.8%、94.7%、90.1%、89.7%、97.8%。MSCTA评估膝下动脉非严重钙化节段和严重钙化节段血管狭窄≥50%的敏感度、特异度、准确度、约登指数、阳性预测值、阴性预测值分别为95.1%、93.2%、94.1%、88.3%、93.4%、94.9%和100%、73.9%、89.3%、73.9%、84.6%、100%。DSA和MSCTA诊断膝上动脉和膝下动脉血管狭窄≥50%非严重钙化节段和严重钙化节段的一致性均良好(Kappa值分别为0.958和0.887;0.882和0.770;均P<0.01)。结论 MSCTA诊断糖尿病足病人下肢动脉狭窄程度时,膝上动脉严重钙化节段的评价指标均略低于非严重钙化者,膝下动脉严重钙化节段的特异度及阳性预测值明显低于非严重钙化者,而敏感度及阴性预测值略高于非严重钙化者,提示膝下动脉严重钙化易造成MSCTA对管腔狭窄程度的高估。     

CT冠状动脉成像与冠状动脉造影诊断冠心病对照研究

目的 探讨64层螺旋CT冠状动脉成像与冠心病的共性及差异,为临床诊断提供依据。资料与方法 49例拟诊为冠心病的患者先后行64层螺旋CT冠状动脉成像机冠状动脉造影检查,依据美国心脏病学会15段分段法,评价所有有效节段,并将两者进行对比分析。结果 共评价493段冠状动脉血管,其中29段血管CT冠状动脉成像与CAG结果不符;以CAG作为“金标准”,CT冠状动脉成像检出冠状动脉狭窄的敏感度、特异度、阳性预测值和阴性预测值分别为91.6%、95.4%、91.0%和95.7%。结论 64层螺旋CT冠状动脉成像与CAG在诊断冠心病方面有较高的一致性,64层螺旋CT冠状动脉成像可以对斑块性质做出评价,但对小血管狭窄的评估不及CAG。     

64层螺旋CT诊断冠状动脉不同程度狭窄的临床价值

目的 用传统的冠状动脉造影作对照,评价64层螺旋CT诊断冠状动脉不同程度狭窄的准确性与一致性.方法 78例患者临床怀疑冠心病并同期接受64层螺旋CT冠状动脉成像及常规冠状动脉造影,计算64层螺旋CT检测冠状动脉严重狭窄(管腔狭窄＞75%)、中等度狭窄(管腔狭窄＞50%)和轻度狭窄(管腔狭窄≤50%)的敏感性、特异性、阳性预测值、阴性预测值.按图像质量(4分法)对冠状动脉节段进行分组,探讨图像质量对64层螺旋CT诊断冠状动脉狭窄的影响.定性与定量比较64层螺旋CT与QCA诊断冠状动脉狭窄的一致性.结果 64层螺旋CT检测冠状动脉狭窄总体敏感性、特异性、阳性预测值、阴性预测值分别为:93.4%、97.9%、88.3%、98.9%.诊断严重、中等度及轻度冠状动脉狭窄的敏感性为81%、59%、75%,特异性为98%.64层螺旋CT能够显示的冠状动脉节段有999段,图像质量为4分的有17段.64层螺旋CT与QCA诊断冠状动脉狭窄一致性的Kappa值=0.7856,P<0.01,两者一致性有统计学意义.相关系数r=0.661,P<0.01,具有正相关关系.结论 64层螺旋CT是一种有效的无创性的检测冠状动脉狭窄的工具.其与QCA诊断冠状动脉不同程度狭窄具有正相关关系.     

64层螺旋CT血管成像对颈动脉分叉处病变的临床应用

目的探讨64层螺旋CT血管成像(CTA)在诊断颈内动脉狭窄和粥样硬化斑块中的价值,并与当前血管成像的金标准DSA进行比较。方法对40例病人(80个颈动脉)进行了CTA和DSA检查,两项检查时间间隔不超过1周,并将CTA与DSA结果进行对照,计算出两者之间的敏感度和特异度。结果CTA对轻度(狭窄程度:0～29%)颈动脉狭窄和颈动脉闭塞显示得非常好,其敏感度和特异度均接近100%。在明确经DSA测量狭窄程度>50%的狭窄时,CTA敏感度、特异度分别为89%、91%。CTA在鉴别狭窄程度为50%～69%或70%～99%时的特异度高,而敏感度较低,分别为65%和73%。CTA同时可以检出DSA不能发现的所有类型的斑块。结论64层CTA在显示颈内动脉狭窄方面与DSA有很好的一致性,同时可发现与颈动脉狭窄相关的溃疡,而DSA只能显示狭窄。     

MSCTA诊断下肢动脉闭塞性疾病

目的：探讨16层螺旋CT对下肢动脉闭塞性疾病的诊断价值。方法：对40例临床可疑外周动脉闭塞性疾病的患者行下肢动脉16层螺旋CT血管成像,其中30例患者于CTA检查前或后两周内行DSA检查,以DSA为金标准,评价CTA诊断的准确性。结果：CTA诊断下肢动脉狭窄（≥50%）的敏感度为95.56%（129/135）,特异度为98.20%（545/555）,符合率97.68%（674/690）,阳性预测值98.88%（176/178）,阴性预测值99.61%（512/514）。结论：16层螺旋CT对诊断下肢动脉闭塞性疾病有较高的敏感性、特异性和准确性,可部分替代DSA检查。     

64层螺旋CT与DSA在冠状动脉造影中的应用分析

目的 探讨并对比64层螺旋CT （MSCT）冠状动脉造影与DSA对冠状动脉各节段病变的检测情况.方法 收集2010年12月～2011年12月我院收治的92例患者64层螺旋CT和DSA检查临床资料.观察并比较两种方法对冠状动脉各阶段狭窄病变的检测情况.结果 CT检出冠脉狭窄的敏感度、特异度、阳性预测值和阴性预测值分别为91.1％、94.6％、90.0％和95.3％.经过与DSA对照,MSCT检测出的冠状动脉各段病变数、钙化斑块及非钙化斑块数与DSA相近.结论 64层螺旋CT与DSA在诊断冠状动脉各段病变及狭窄程度上准确度相似,具有一致性.64层CT在冠脉狭窄病变中具有重要的临床价值,值得在临床上广泛应用.     

64层螺旋CT冠状动脉成像与冠状动脉造影的对比研究

目的评价64层螺旋CT冠状动脉成像诊断冠状动脉狭窄的准确性。方法 50例患者先后进行64层螺旋CT冠状动脉成像和冠状动脉造影检查,以冠状动脉造影为诊断冠状动脉疾病的"金标准",比较CT冠状动脉成像的符合率,评价64层螺旋CT冠状动脉成像诊断冠心病的准确性。结果 64层螺旋CT冠状动脉成像评价冠状动脉狭窄程度大于或等于50%的敏感性为98.6%,诊断狭窄程度小于50%的敏感性为87.0%,诊断冠状动脉狭窄的特异性为92.5%,阴性预测值为97.7%。结论 64层螺旋CT冠脉成像诊断冠状动脉狭窄有很高的准确率。     

16层螺旋CT在下肢动脉闭塞性疾病中的应用价值

目的:探讨16层螺旋CT血管成像术在诊断下肢动脉闭塞性疾病中的应用价值。方法:对42例临床疑为外周动脉闭塞性疾病的患者行下肢动脉16层螺旋CT血管造影(CTA),扫描范围从肾动脉水平达足底。薄层重建横断面图像传入HP xw8000工作站,进行血管三维重建。所有患者于CTA检查前或后2周内行数字减影血管造影(DSA)。以DSA为金标准,评价CTA诊断的准确性。结果:在882个动脉节段中,870个节段在CTA与DSA均可以显示,在DSA图像上,狭窄闭塞的节段共260个(轻度狭窄32段,中度狭窄24段,重度狭窄44段,闭塞160段),最大密度投影(MIP)显示中度以上狭窄的敏感性、特异性及准确性分别为99.1%、99.7%、99.5%。结论:16层螺旋CT在评估下肢动脉闭塞性疾病方面与常规血管造影结果无明显差别,是下肢动脉闭塞性疾病理想的影像学检查手段,可部分替代DSA检查。     

Comparison between 64-row CT angiography and digital subtraction angiography in the study of lower extremities: personal experience

Purpose

This study was undertaken to evaluate the potential of 64-row multislice computed tomography (CT) versus digital subtraction angiography (DSA) in detecting significant lesions of lower-extremity inflow and runoff arteries.

Materials and methods

Fifty-three patients underwent 64-row multislice CT and DSA over a mean of 36 days. The vascular tree was divided into 33 segments. Three readers independently reviewed the axial CT scans and multiplanar oblique and two- and three-dimensional reconstructions (maximum intensity projection and volume rendering) images to assess degree of stenosis according to four categories: 1 (0%–49% stenosis); 2 (50%–99% stenosis); 3 (occluded); 4 (not evaluable). In all cases, DSA was performed by arterial catheterisation.

Results

In 53 patients, 1,440 segments were evaluated (infrarenal aorta and 16 arterial segments for each leg; 42 bilateral studies, 11 unilateral studies). Compared with DSA, CT angiography yielded 97.2% sensitivity, 97% specificity, 92.5% positive predictive value, 98.9% negative predictive value, 97.1% diagnostic accuracy and 95.4% concordance on the degree of stenosis.

Conclusions

Sixty-four-row multislice CT proved to be helpful in detecting haemodynamically significant lesions in peripheral arterial occlusive disease and improved the results obtained with 4- and 16-slice multidetector CT. In addition, owing to the high spatial resolution and rigorous technique, no variations in the data obtained below the knee were detected, overcoming a limitation of earlier generations of CT scanners.     

Multidetector CT angiography of peripheral vascular disease: a prospective comparison with intraarterial digital subtraction angiography

OBJECTIVE: The purpose of this study was to determine the accuracy of CT angiography using a multidetector scanner in the evaluation of patients with peripheral vascular disease. SUBJECTS AND METHODS: Eighteen patients with peripheral vascular disease who were referred for elective digital subtraction angiography (DSA) also underwent CT angiography. We scanned patients from the level of the superior mesenteric artery to the pedal arteries in a single helical scan. CT angiograms were produced using maximum-intensity-projection reconstructions. Findings were graded according to six categories: 1, normal (0% stenosis); 2, mild (1-49% stenosis); 3, moderate (50-74% stenosis); 4, severe (75-99% stenosis); 5, occluded; and 6, nondiagnostic. CT angiography findings were compared with DSA findings for each arterial segment. RESULTS: We found agreement for the degree of stenosis in 77.7% of the arteries and discrepancy for 22.3% of the arteries when all categories were considered. Grouping the six categories according to the threshold for treatment (categories 1 and 2 as one group and categories 3, 4, and 5 as the second group) resulted in an agreement of 91.95%. Compared with DSA, CT angiography yielded a sensitivity of 90.9% and a specificity of 92.4%. CONCLUSION: Multidetector CT angiography is an accurate, noninvasive technique for the imaging of peripheral vascular disease.     

Aortoiliac and lower extremity arteries assessed with 16-detector row CT angiography: prospective comparison with digital subtraction angiography

PURPOSE: To prospectively compare the accuracy of 16-detector row computed tomographic (CT) angiography with conventional digital subtraction angiography (DSA) as the reference standard in the assessment of aortoiliac and lower extremity arteries in patients with peripheral arterial disease. MATERIALS AND METHODS: This study was approved by the institutional review board, and informed consent was obtained. A total of 39 consecutive patients (27 men [mean age, 66 years] and 12 women [mean age, 64 years]) with peripheral arterial disease underwent both conventional DSA and 16-detector row CT angiography. For data analysis, the arterial vascular system was divided into 35 segments. A total of 1365 arterial segments were analyzed for arterial stenosis by two independent blinded readers using a four-point grading system (grade 1, <10% luminal narrowing; grade 2, 10%-49% luminal narrowing; grade 3, 50%-99% luminal narrowing; grade 4, occlusion). Interobserver agreements were calculated by using kappa statistics. A third independent blinded reader assessed possible reasons for disagreements between 16-detector row CT angiographic findings and conventional DSA findings. Effective radiation dose was calculated for both imaging modalities. RESULTS: Sixteen-detector row CT angiographic and conventional DSA findings were diagnostic in all vascular segments. Compared with conventional DSA, the sensitivity and specificity of 16-detector row CT angiography with regard to detection of hemodynamically significant stenosis in all 35 arterial segments were 96% and 97%, respectively, for both readers. Readers 1 and 2 overestimated arterial stenosis in 42 (3%) and 34 (2%) arterial segments, respectively, and underestimated arterial stenosis in 13 (1%) and 10 (1%) arterial segments, respectively. Interobserver agreement was excellent (kappa = 0.84-1.00). Presence of anteroposteriorly located luminal narrowing and extensive vascular wall calcification were considered main reasons for disagreements between imaging modalities. Effective radiation dose was lower for 16-detector row CT angiography (1.6-3.9 mSv) than for conventional DSA (6.4-16.0 mSv). CONCLUSION: Sixteen-detector row CT angiography is an accurate and reliable noninvasive alternative to conventional DSA in the assessment of aortoiliac and lower extremity arteries in patients with peripheral arterial disease.     

64层螺旋CT对下肢动脉疾病的诊断及其临床价值

目的 探讨64层螺旋CT对下肢动脉狭窄闭塞性疾病的诊断价值. 资料与方法 对40例下肢动脉闭塞性疾病患者行64层CT容积扫描,15例1周内同时行数字减影血管造影（DSA）.将下肢血管分成8段,每段血管的狭窄程度被分为：正常、轻度狭窄、中度狭窄、重度狭窄、闭塞5个级别.将DSA与CTA结果进行比较. 结果 共对198个动脉段进行研究,对其狭窄程度显示一致的有191个,被CTA高估6个,低估1个.一致性检验Kappa值为0.953,P=0.017＜0.05,两者分析结果的一致性较好. 结论 64层螺旋CTA是下肢动脉狭窄硬化性疾病的可靠评估方法.     

Evaluation of peripheral artery stent with 64-slice multi-detector row CT angiography: Prospective comparison with digital subtraction angiography

Purpose

To assess the accuracy of 64-slice multi-detector row computed tomography (MDCT) angiography in the evaluation of peripheral artery in-stent or peristent restenosis, with conventional digital subtraction angiography (DSA) as the reference standard.

Materials and methods

Forty-one patients (30 men, 11 women; mean age, 69.8 ± 9.2 years) with symptomatic peripheral arterial occlusive disease after peripheral artery stenting (81 stented lesions) underwent both conventional DSA and 64-slice MDCT angiography. Each stent was classified as evaluable or unevaluable, and every stent was divided into three segments (proximal stent, stent body, and distal stent), resulting in 243 segments. For evaluation, stenosis was graded as follows: 1, none or slight stenosis (<25%); 2, mild stenosis (25-49%); 3, moderate stenosis (50-74%); 4, severe stenosis or total occlusion (≥75%). Two readers evaluated all CT angiograms with regard to narrowing of in-stent or peristent restenosis by consensus. Results were compared with findings of the DSA.

Results

Of 81 stents, 62 (76.5%) were determined to be assessable. The metal artifact of the gold marker and motion artifact increased uninterpretability of the images of stents. Overall, 24 of 28 in-stent restenosis and 38 of 53 persistent restenosis were correctly detected by MDCT (85.7% and 71.7% sensitivity). In evaluable stents, 21 of 22 in-stent restenoses and 27 of 28 persistent restenosis were correctly detected (95.4% and 96.4% sensitivity). Additionally, as the grade of stenosis increases, the mean level of CT values in the stent lumina decreases linearly accordingly.

Conclusion

64-Slice MDCT has a high accuracy for the detection of significant in-stent or peristent restenosis of assessable stents in patients with peripheral artery stent implantation and therefore can be considered as a valuable noninvasive technique for stent surveillance.     

64层螺旋CT血管成像对下肢动脉系统疾病的应用价值

目的:探讨64层螺旋CT血管成像术在下肢动脉疾病中的应用价值及技术优势。方法:对21例疑有下肢动脉疾病患者行64层螺旋CT增强扫描,扫描范围从肾动脉水平达足底。薄层重建横断面图像传入Wizard工作站,进行血管三维重建。其中21例结合常规血管造影评价64层螺旋CT血管成像术(CTA)的准确性。结果:在441个动脉节段中,435个节段在CTA与DSA均可以显示,在DSA图像上,狭窄闭塞的节段共130个(轻度狭窄16段,中度狭窄12段,重度狭窄22段,闭塞80段),最大密度投影(MIP)显示中度以上狭窄的敏感性、特异性及准确性分别为:99.1%、99.7%、99.5%。结论:64层CT血管成像是一种高度准确、非侵袭性的成像技术,在评估下肢动脉疾病方面与常规血管造影结果无明显差别,是下肢动脉疾病较好的影像学检查手段。     

Diagnostic accuracy of multislice CT angiography in peripheral arterial disease

A systematic search of the PubMed and Medline databases of English literature was performed to determine the diagnostic accuracy of multislice computed tomographic (CT; MSCT) angiography in peripheral arterial disease (PAD) compared with digital subtraction angiography (DSA). Studies comparing MSCT angiography with DSA in peripheral vascular disease were included, and the diagnostic value of MSCT angiography in terms of sensitivity, specificity, and diagnostic accuracy was compared and analyzed. Ten studies (19 comparisons) met the criteria and were included for analysis. The pooled sensitivity, specificity, and accuracy rates were 92%, 91%, and 91%, respectively, at all arterial levels; 92%, 94%, and 93%, respectively, at aortoiliac arteries; 96%, 85%, and 92%, respectively, at femoropopliteal arteries; and 91%, 85%, and 87%, respectively, at infrapopliteal arteries. A significant difference was found in the sensitivity of MSCT angiography in PAD between four-slice CT and 16-slice CT, between aortoiliac and femoropopliteal arterial segments, and between femoropopliteal and infrapopliteal arterial segments (P<.05). This review demonstrates that MSCT angiography has a high diagnostic value and could be a reliable alternative to DSA in the diagnosis of PAD.