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1.
目的:研究肾石通颗粒的喷雾干燥条件与成型工艺。方法:采用单因素试验法,以干粉得率为考察指标,确定浸膏相对密度、喷雾压力、进风温度、进液频率、风机频率等喷雾干燥工艺参数。结果:喷雾干燥工艺参数为浸膏相对密度1.18~1.23(60℃),物料温度50℃,进风温度80℃,喷雾压力0.15~0.20Mpa,进液频率15~25Hz,风机频率20~30Hz时肾石通颗粒成型最好。结论:本研究喷雾干燥条件与成型工艺合理、可行,可用于肾石通颗粒的制备。  相似文献   

2.
非晶形醋酸麦迪霉素的制备及其理化性质   总被引:6,自引:1,他引:5  
以乙基纤维素为稳定剂,三氯甲烷为溶媒,用喷雾干燥法制备较稳定的非晶形醋酸麦迪霉素。探讨了喷雾条件对非晶形转化的影响,同时,进行了其晶形与非晶形理化特性的比较。  相似文献   

3.
目的优化喷雾干燥乳剂处方。方法联用羟丙甲纤维素(HPMC)和蔗糖作固体载体,椰子油作油相,采用喷雾干燥工艺制备O/W型干乳剂。结果根据乳化性能及喷雾可操作性筛选出适于采用喷雾干燥法制备干乳剂的处方。即固体载体HPMC适宜黏度为3mPa.s,浓度为8%。结论HPMC的黏度和浓度对液体O/W乳剂的稳定性及经喷雾干燥制成干乳剂有一定影响,含高黏度HPMC的液体O/W乳剂不容易雾化,易堵塞雾化器的喷嘴。低黏度HPMC是一种有用的固体载体,并起到一定的乳化作用。  相似文献   

4.
将薄膜包衣和喷雾干燥等多种技术应用于流化床喷雾制粒,阐述了清开灵颗粒流化床喷雾制粒过程控制中多参量的考察与应用,对生产中经常出现的问题进行了深入研究,使多种技术措施综合应用于流化床喷雾制粒。  相似文献   

5.
喷雾干燥法制备微囊的原理是将水溶液以微细液滴喷入到热空气中,待水蒸发后,分离出干燥的固体。由于液体通过喷雾分成很小的粒子,液体表面积变得相当大,促进了热交换,这样水分的蒸发在瞬间完成,故得到几乎是球形的粉末。喷雾干燥可对热不稳定的材料,如酶类进行包微囊,往往没有严重的降解现象。影响喷雾干燥包囊的因素包括:起始液的浓度、粘度、温度及芯料与衣料的比例等。起始液有三种类型,即水溶液、有机溶液和胶囊浆液。喷雾用的起始水溶液,是将水不溶性的芯料,在适当的温度下分散在衣膜材料的水  相似文献   

6.
目的 采用喷雾干燥法制备二甲双胍肠溶缓释微囊并对其体外释放度进行考察.方法 以包封率为评价指标,对喷雾干燥工艺参数进行正交优化设计,并考察Eudragit L100用量、微囊芯材比对微囊性能的影响.结果 最优工艺条件为进风温度165℃;进料速度10 mL·min-1;喷雾压力0.3 MPa;药物与Eudragit L1...  相似文献   

7.
吸入用肽类和蛋白质粉末的制备   总被引:1,自引:0,他引:1  
蛋白质和肽类利用气雾剂给药有许多优点。制备大小合适的吸入性粉末常用的技术是喷射碾磨和喷雾干燥方法,其制已在实验动物和临床进行了研究。另外,简介了粉末的其他制备方法。  相似文献   

8.
目的采用喷雾干燥法制备右美沙芬的1:3服液体缓释制剂。方法以喷雾干燥法制备药物树脂缓释微粒,之后制成缓释混悬剂。并以高效液相法(HPLC)测定自制缓释混悬剂和市售品的含量和释放度,最后以相似因子法对2种制剂进行体外释药行为的评价。结果喷雾干燥法制备的缓释混悬剂,含量、释放度均符合市售品的质量标准,且体外释药行为与市售品无显著差异。结论喷雾干燥法也是一种制备口服液体缓释制剂的优良方法。  相似文献   

9.
喷雾干燥与沸腾造粒法制备热咳停颗粒   总被引:1,自引:1,他引:1  
韩俊  张明伟  张长弓 《医药导报》2006,25(2):146-147
目的研究热咳停颗粒剂的喷雾干燥条件与成型工艺。方法通过考察影响干燥与成型的单个因素,包括物料相对密度、入塔风压、进出风温度、辅料种类与用量、制粒工艺等,确定最佳喷雾干燥条件及成型工艺。结果喷雾干燥工艺参数为60 ℃下药液相对密度为1.10,入塔风压为-1 700 Pa,进风温度为160~170 ℃,出风温度为70~80 ℃,干浸膏粉与糊精比例为8∶3,浸膏相对密度为1.10(60 ℃),沸腾制粒浸膏与喷雾干燥浸膏比例为1∶2;沸腾造粒参数为进液速度50~55 mL·min-1,喷雾压力0.37 MPa,物料温度为55~60 ℃,进风温度78~88 ℃,出风温度40~45 ℃,室内温度20 ℃,相对湿度50%时成型最好。结论该喷雾干燥条件与成型工艺合理、可行,可用于热咳停颗粒剂的制备。  相似文献   

10.
目的:优选柴藿颗粒浸膏喷雾干燥的最佳工艺条件.方法:采用L9(34)正交实验法对影响浸膏喷雾干燥的工艺条件:浸膏密度(A)、喷雾速度(B)、出口温度(C)进行考察,每个因素三个水平,并以柴藿颗粒浸膏喷雾干燥的出粉率为考察指标.结果:柴藿颗粒浸膏喷雾干燥最佳工艺条件为A1B3C2,即浸膏密度0.8 g/mL、喷雾速度2 mL/min、出口温度80℃.结论:该工艺稳定、有效、可控,为中试生产工艺提供了科学的理论依据.  相似文献   

11.
目的: 考察干燥工艺对黄芪桂枝五物汤粉体的物理指纹图谱和有效成分含量的影响,优选出最佳干燥方法。方法: 采用冷冻干燥、真空干燥和喷雾干燥法制备粉体,以5个一级指标和11个二级指标构建物理指纹图谱,并测定其有效成分(黄芪甲苷、毛蕊异黄酮葡萄糖苷、芍药苷、肉桂酸、总多糖)含量。通过11个二级指标评价粉体学性质,建立相应的物理指纹图谱;采用相似度评价和主成分分析法对比其物理指纹图谱;通过计算可压性参数评价粉体的压缩成型性。结果: 3种粉体的有效成分含量无显著性差异(P>0.05)。3种粉体均具有较好的可压性、较差的稳定性和流动性,其中喷雾干燥具有良好的均一性,冷冻干燥和真空干燥具有良好的堆积性。3种干燥工艺的物理指纹图谱相似度75.5%~95.4%。结论: 干燥工艺对黄芪桂枝五物汤物理指纹图谱影响较大,以喷雾干燥为最佳。  相似文献   

12.
喷雾干燥对溶菌酶一级结构的影响   总被引:1,自引:1,他引:1  
目的 考察喷雾干燥对溶茵酶一级结构稳定性的影响。方法 以送料速度2.4 ml/min、进口气流温度150℃、出口气流温度70℃、雾化器转速18 000 r/min制备喷雾干燥溶茵酶。采用MALDI-TOF/MS测定喷雾干燥对溶菌酶一级结构的影响。结果 喷雾干燥溶菌酶除了具有溶菌酶相同的准分子离子峰、二聚体、三聚体、四聚体及三聚体的两电荷离子峰外,另多5个碎片离子峰。结论 喷雾干燥可造成溶菌酶一级结构破坏。  相似文献   

13.
The effect of spray drying lactose alone and in the presence of polyethylene glycol 4000 was investigated. Lactose was added to distilled water to give concentrations of 10, 20, 30 and 40g/100ml at room temperature and each spray dried in turn. Identical samples were prepared to which polyethylene glycol (PEG) 4000 was added (12% by weight of lactose) prior to spray drying. Microcalorimetric and X-ray diffraction studies showed that spray drying lactose solutions produced completely amorphous material due to rapid solidification during the spray drying process, whereas lactose suspensions yielded partially crystalline products due to crystalline material that remained in suspension. However, all the PEG/lactose (12%w/w) co-spray dried products were found to be crystalline. It can be inferred that the solidification rates of the lactose in the presence of PEG must have been slower than that of lactose alone which allowed PEG and lactose to crystallize. The PEG/lactose products that were spray dried from solution consisted of alpha-anhydrous, alpha-monohydrate, beta-lactose and PEG extended chain polymorph, whereas those formed from suspension PEG/lactose samples consisted of only alpha-anhydrous, alpha-monohydrate and extended chain PEG crystals. PEG probably caused the more concentrated lactose suspensions to crystallize slowly due to the strong hydrogen bonding between PEG and water, which allowed growth on the alpha-lactose seed crystals.  相似文献   

14.
目的 优选舒肝散结片的干燥工艺.方法 比较减压干燥和喷雾干燥对舒肝散结片的干燥效果,并采用正交试验设计,优选喷雾干燥的条件.结果 进风温度为(190±2)℃,排风温度为(90±2)℃,提取液浓缩至相对密度为1.15~1.20(60℃测定)时喷雾效果最好.结论 喷雾干燥适合作为舒肝散结片的干燥工艺.  相似文献   

15.
Continuous production of directly compressible powders was achieved by coprocessing acetaminophen and carbohydrates via spray drying. Binary and ternary powder mixtures containing drug substance and carbohydrates were prepared by co-spray drying and evaluated on spray drying processibility, powder hygroscopicity, flowability, and compactability. The influence of process parameters during spray drying on the compaction behaviour of drug/excipient mixtures was investigated via Heckel analysis. Erythritol, lactose, maltodextrin, and mannitol were efficient in co-spray drying with acetaminophen. However, lactose mixtures showed poor flowability. Spray dried mixtures containing mannitol and erythritol were characterised as non-hygroscopic, highly dense, and good flowing powders. Mannitol increased tablet tensile strength in contrast with the poor compactability of erythritol. Maltodextrin was selected for further experiments because it provided excellent tablet tensile strength. The use of erythritol, maltodextrin and mannitol in binary drug/excipient mixtures resulted in high process yields. Compacts of erythritol, mannitol, and maltodextrin were characterised by higher tablet tensile strength at higher spray drying temperatures due to the increased particle fragmentation of erythritol and mannitol mixtures and to the increased plastic deformation of maltodextrin formulations. A combination of erythritol, maltodextrin, and mannitol was selected for further formulation and process optimisation of co-spray dried powders for direct compression.  相似文献   

16.
A formulation and process development study was performed to formulate recombinant human deoxyribonuclease I as a powder for inhalation. First, excipient compatibility (with bovine DNase as a model substance) was examined with a stability study at stressed conditions (60 and 85°C) while monitoring for occurrence of the Maillard reaction. Next, powders for inhalation were prepared by spray drying and spray freeze drying. We found that spray drying with inulin as stabilizer resulted in the best powder for inhalation. Finally, an ex-vivo test with the spray dried rhDNase I/inulin powder significantly decreased elastic and viscous moduli of sputum from five cystic fibrosis patients.  相似文献   

17.
目的:建立一种干燥的固体脂质纳米粒的制备方法。方法:采用超声分散法制备黄豆苷元固体脂质纳米粒的混悬液,然后采用喷雾干燥法将其制成干燥的、可再分散的固体脂质纳米粒。结果:在混悬液中黄豆苷元固体脂质纳米粒为球形粒子,平均粒径约为280 nm,喷雾干燥后得到的纳米粒仍为球型,分散后的粒径与喷干前相比有所增大,平均粒径约为720 nm,稳定性较好。结论:喷雾干燥法制备黄豆苷元固体脂质纳米粒是可行的。  相似文献   

18.
目的比较喷雾干燥法与减压干燥法对秦香止泻干浸膏粉吸湿性及流动性的影响,为确定秦香止泻浓缩液(或稠浸膏)合理的干燥方法提供依据。方法通过测定秦香止泻干浸膏粉的吸湿速度,吸湿量达2%时的相对湿度(relative humidit,RH),建立其动力学模型,提取吸湿速度参数并比较大小;通过测定秦香止泻干浸膏粉的休止角比较流动性优劣。结果两种干燥方法制成的干浸膏粉吸湿动力学模型皆符合对数正态分布模型,减压干燥比啧雾干燥吸湿速度快,吸湿量随RH变化的函数关系,喷雾干燥粉符合逻辑斯蒂模型;减压干燥粉符合修正指数函数曲线,吸湿量达2%时的RH,喷雾干燥粉为90.12%;减压干燥85.81%,减压干燥法比喷雾干燥法制成的干浸膏粉休止角大,流动性差。结论喷雾干燥制成的干浸膏粉不易吸湿,稳定性好,流动性好。  相似文献   

19.
不同干燥条件大黄水提物的外观及理化性质比较研究   总被引:1,自引:0,他引:1  
李华  王强  金城  肖小河 《中国药业》2009,18(24):25-27
目的研究不同干燥方式对大黄水提物外观及理化性质的影响。方法分别采用真空、常压、喷雾、微波和冷冻干燥等5种不同干燥方式对大黄水提物进行干燥,测定并比较各样品的外观质地、pH及相对临界湿度(CRH)的差异。结果不同干燥方式样品的外观性状差异较大,pH差异不大;CRH由大到小依次为常压干燥、微波干燥、真空干燥、冷冻干燥、喷雾干燥样品,其中喷雾干燥样品最小且与常压干燥样品有显著差异(P〈0.05)。结论干燥方式对样品的外观及理化性质影响明显。喷雾干燥样品的吸湿性增大,对产品的稳定性有一定影响。  相似文献   

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