慢性荨麻疹患者甲状腺自身抗体的检测

[目的]探讨特发性慢性荨麻疹及已知病因的慢性荨麻疹与甲状腺自身免疫性的关系.[方法]采用放射免疫法,对78例特发性慢性荨麻疹和80例已知病因的慢性荨麻疹患者的甲状腺自身抗体及甲状腺功能进行检测,并与40例正常体检人群对照.[结果]78例的特发性慢性荨麻疹患者血清中11例(14%)抗甲状腺球蛋白抗体(TGA)阳性,10例(13%)抗甲状腺微粒体抗(TMA)阳性;80例已知病因慢性荨麻疹患者中11例(14%)TGA及TMA均阳性.两组慢性荨麻疹的TGA及TMA水平均显著高于正常对照组(P均＜0.01),但两组间差异无显著(P＞0.05).两组慢性荨麻疹及对照组的T4、RT3、FT3、TSH值比较均差异无显著性(P均＞0.05).[结论]部分特发性慢性荨麻疹和已知病因慢性荨麻疹的患者血清中均存在有TGA及TMA,两组慢性荨麻疹发病均可能有自身免疫机制参与.     

TMA、TGA及有关甲状腺激素RIA在桥本氏甲状腺炎中的应用价值

应用RIA检测95例桥本氏甲状腺炎患者血清中TMA和TGA滴度，结果显示95例HT患者TMA和TGA滴度均明显高于正常（P＜0.001）。提示TMA、TGARIA检测对HT具有诊断价值。同时联合检测血清中TSH、FT_3、FT_4和TT_3TT_4含量，结果显示95例HT患者表现甲状腺功能异常61例（占64.2%）。提示HT表现的甲状腺功能状态与甲状腺自身抗体有关。     

TGA、TMA与~(131)I治疗甲亢与甲低发生的关系

目的探讨甲亢患者血清TGA、TMA在131I治疗后发生甲状腺功能低下(简称甲低)的关系。方法对246例甲亢患者131I治疗前检测TGA、TMA阳性和阴性的比值。结果246例甲亢,TGA、TMA阳性98例,发生甲低35例,占35.71%。TGA、TMA阴性148例,发生甲低8例,占5.41%。两组甲低发生率比较差异有高度显著性(χ2=37.55,P<0.01)。结论TGA、TMA阳性患者131I治疗甲亢后引发甲低率较高。     

甲状腺疾病血清TMA和TGA放免测定的临床应用评价

本文以放免法对200例各类甲状腺疾病患者,进行了血清甲状腺微粒体抗体(TMA)和甲状腺球蛋白抗体(TGA)含量的测定,结果报告如下。资料与方法资料200例甲状腺疾病患者系我院门     

Graves病患者血清胰岛素抗体的检测及其临床意义

用SAB—ELISA检测63例Graves病患者及30例正常对照者血清胰岛素自身抗体(1AA)。15.87％Graves病患者血清中存在IAA,正常对照者无一例检测到IAA。提示Graves病患者抗体的产生具有异质性,该类患者可能存在多克隆B淋巴细胞功能失调。对IAA与TSH受体抗体(TRAb)、甲状腺刺激性免疫球蛋白(TSI)、抗甲状腺球蛋白抗体(TGA)、抗甲状腺微粒体抗体(TMA)及与药物治疗的关系进行了讨论。     

甲亢治疗中抗甲状腺药物对自由基和自身抗体的影响

本文测定甲亢病人抗甲状腺药物治疗前后血清SOD、TGA、TMA的浓度变化,发现治疗后甲状腺功能正常者血清SOD浓度升高和TGA、TMA浓度降低,提示抗甲状腺药物有清除超氧离子和调及机体免疫功能的作用。     

慢性淋巴细胞性甲状腺炎的诊断和治疗(附49例报告)

目的 :探讨慢性淋巴细胞性甲状腺炎 (CLT)的诊断 ,以及CLT合并其它甲状腺疾病的治疗方案选择。方法 :回顾性分析该院 1988～ 2 0 0 1年收治的 4 9例CLT的临床资料。结果 :术前诊断 11例 ,诊断率为 2 2 .4 %(11/ 4 9) ,其中经细针穿刺细胞学检查 (FNAC)诊断 10例 ,均予以甲状腺素片治疗 ,疗效满意。其余 38例分别误诊为其它甲状腺疾病而施行手术 ,其中合并甲亢 5例 ,合并结节性甲状腺肿 5例 ,合并甲状腺腺瘤 4例 ,合并甲状腺癌 3例 ;手术组中随访 2 7例 (71.1% ) ,6例发生甲低。结论 :全面的血清免疫学检查 ,结合FNAC检查可提高CLT的诊断率。该病以非手术冶疗为主 ,对合并其它病变者 ,应根据病理类型选择合理的治疗方案。     

由状腺疾病血清TGA和MCA放射免疫测定的临床意义

本文报告了应用放射免疫法对甲状腺疾病患者血清甲状腺球蛋白抗体(TGA)和甲状腺微粒体抗体(MCA)的测定水平。结果表明,自身免疫性甲状腺疾病患者TGA,MCA 总阳性率明显高于非自身免疫性甲状腺疾病患者。提示对自身免疫性疾病与非自身免疫性甲状腺疾病进行TGA 和MCA 测定,对其诊断与鉴别诊断具有重要的临床意义。     

甲亢~(131)I治疗后甲低的发生与甲状腺自身抗体的关系

目的:探讨甲状腺功能亢进(简称甲亢)131I治疗后甲状腺功能减退(简称甲低)的发生与甲状腺自身抗体的关系,确定适宜131I治疗的甲亢类型。方法:190例甲亢患者,据甲状腺自身抗体不同分为A组64例,促甲状腺受体抗体(TRAb)阴性,甲状腺球蛋白抗体(TGA)、甲状腺微粒体抗体(TMA)阳性;B组74例,TRAb、TGA、TMA均为阳性;C组52例,TRAb阳性,TGA、TMA阴性。各组采用相同的方法给予131I治疗,治疗后定期随访,计算各组1a、3a的甲低发生率,并进行各组间的比较。结果:131I治疗后1a甲低发生率分别为A组19.9%,B组7.9%,C组2.0%,A组显著高于C组(P<0.01);3a甲低发生率分别为A组36.0%,B组17.2%,C组4.4%,A组显著高于B组、C组(P<0.01);B组显著高于C组(P<0.05)。结论:甲亢131I治疗后甲低的发生与甲状腺自身抗体类型有关。TRAb阳性,TMA、TGA阴性的甲亢患者,采用131I治疗较适宜。     

核医学检查诊断亚急性甲状腺炎63例临床分析

目的:评价核医学检查在亚急性甲状腺炎诊断中的价值。方法:对63例亚急性甲状腺炎患者的有关检查结果进行分析;所有患者均进行FT3、FT4、TSH及TGA、TMA、TG的血清学检测,同时进行甲状腺摄I131功能测定和甲状腺显像检查。结果:42例(66.7%)患者的血清激素水平有不同程度的改变,典型特征的分离现象为61.9%。结论:甲状腺显像和甲状腺摄I131率测定是诊断亚急性甲状腺炎必不可少的重要方法。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…