PVP、TURP治疗良性前列腺增生症疗效比较

目的 比较经尿道选择性绿激光前列腺汽化术(PVP)与前列腺电切术(TURP)治疗良性前列腺增生症(BPH)的疗效.方法 将50例BPH患者随机分为两组,分别TURP和PVP,比较两组患者手术时间、术中出血量、手术前后症状改善情况、术后膀胱冲洗时间、留置导尿管时间、住院时间及近期并发症发生情况.结果 两组患者术后前列腺国际症状评分(IPSS)、生活质量评分(QOL)、最大尿流率和残余尿量均较术前明显改善(P均＜0.01),但两组上述指标间比较差异无显著性(P均＞0.05);PVP组术中出血量、术后膀胱冲洗时间、留置导尿管时间、住院时间明显短于TURP组(P均＜0.05),但其手术时间明显长于TURP组(P均＜0.01);PVP组患者术后尿失禁、尿道狭窄、血尿等并发症发生率明显低于TURP组(P均＜0.05).结论 PVP与TURP均能显著改善轻、中度前列腺增生患者的症状,具有相似的临床疗效.与TURP相比,PVP操作安全、术中出血少、术后并发症少,患者恢复快.     

前列腺增生症合并心力衰竭电汽化术的治疗体会

目的分析前列腺增生症合并心力衰竭电汽化术的治疗体会。方法选择我院2012年9月~2015年8月收治的前列腺增生症合并心力衰竭患者38例作为研究对象,所有患者均采用经尿道前列腺电汽化术是治疗,回顾性分析患者的临床资料,探讨疗效。结果所有患者均获得较好的疗效,患者满意度达到94.74%。结论前列腺增生症合并心力衰竭患者的身体状况较差,无法耐受开放性手术的伤害,经尿道前列腺电汽化手术是较为理想的治疗方式。     

经尿道前列腺汽化电切术治疗前列腺增生症的体会

目的 探讨经尿道前列腺汽化电切术治疗前列腺增生症的临床效果. 方法 采用经尿道前列腺汽化电切术治疗前列腺增生症患者106例. 结果 平均手术时间80 min,手术顺利,出血量少,无经尿道电切综合征发生,疗效满意. 结论 经尿道前列腺汽化电切术是治疗前列腺增生症的理想方法 ,其安全性高,疗效显著,并发症少,值得推广.     

经尿道选择性KTP激光汽化术治疗良性前列腺增生症(附47例报告)

前列腺增生症(BPH)是中老年男性泌尿系统最常见的疾病之一,发病率随年龄递增。药物治疗及传统的手术切除存在疗效差或手术风险大的缺点。经尿道选择性磷酸钛氧钾晶体(KTP)激光前列腺汽化术(PVP)以手术创伤小、术后恢复快、并发症少等优点,可能取代经尿道前列腺电切术(TURP),成为新一代治疗BPH的金标准。2004年10月至2005年2月,我们采用PVP术治疗BPH患者47例,取得较好效果。现报告如下。     

经尿道部分前列腺汽化电切术治疗高危前列腺增生症

目的 探讨治疗高危前列腺增生症(BPH)安全有效的手术方法.方法 对121例高危BPH患者采用联合经尿道汽化电切(TUVP)和经尿道电切(TURP)部分前列腺进行治疗.结果 切除前列腺重量15～70 g,平均47.5 g,手术时间30～105 min,平均55 min,失血量80-210 ml,无电切综合征(TRUS)发生,无手术死亡,术后国际前列腺症状评分(IPSS)明显下降、生活质量评分(QOL)明显提高.结论 联合经尿道部分前列腺汽化电切和电切术治疗高危前列腺增生症是安全有效的手术方法.     

TURP联合电切镜下钬激光碎石治疗BPH合并膀胱结石疗效观察

目的 探讨经尿道前列腺电切术(TURP)联合电切镜下钬激光碎石治疗前列腺增生症(BPH)合并膀胱结石的疗效.方法 采用TURP联合电切镜下钬激光碎石治疗BPH合并膀胱结石患者60例.结果 手术均获得成功,手术时间50 ～ 130 min,平均80 min,术中出血量为30～ 100 mL,平均60 mL,均未输血.术后无结石残留,术后5～7d拔除导尿管,均能自行排尿,无尿失禁.术后3个月国际前列腺症状评分(IPSS)明显低于术前,P＜0.05.结论 TURP联合电切镜下钬激光碎石治疗BPH合并膀胱结石疗效确切.     

经尿道半导体激光前列腺剜除术的临床应用

目的探讨经尿道半导体激光前列腺剜除术在临床上的应用。方法良性前列腺增生(BPH)患者310例,根据手术方式分为观察组210例和对照组100例。观察组给予经尿道半导体激光前列腺剜除术治疗;对照组给予经尿道前列腺电切术(TURP)治疗。于术前和术后3个月记录并对比两组国际前列腺症状评分(IPSS)、残余尿量(PVR)、生活质量评分(QOL)及最大尿流率(Qmax),记录并对比两组围术期各项临床指标和手术并发症发生率。结果与术前相比,两组术后3个月IPSS、QOL、PVR显著降低,Qmax显著升高(P<0.05);观察组手术时间、术中出血量、术后膀胱冲洗时间、尿管留置时间、住院时间及手术并发症发生率均低于对照组(均P<0.05)。结论经尿道半导体激光前列腺剜除术和TURP均能有效治疗BPH患者,但前者较TURP优势明显。     

经尿道汽化电切术治疗合并糖尿病的前列腺增生症的疗效观察

目的观察经尿道汽化电切术治疗合并糖尿病的前列腺增生症的临床疗效。方法 2016年12月—2018年1月期间,选择74例前列腺增生症合并糖尿病患者,均行经尿道汽化电切术,观察临床疗效。结果 74例患者,手术均获得成功,成功率100%(74/74),手术时间平均(66.3±7.95)min,术中出血量平均(125.9±11.03)m L,术后,无一例患者出现严重并发症。比较RUV与Qmax水平,术后显著优于术前,差异有统计学意义(P0.05)。结论经尿道汽化电切术治疗合并糖尿病的前列腺增生症,疗效显著,安全可靠,建议在临床推广使用。     

经尿道汽化术联合电切治疗高危前列腺增生症74例疗效观察

良性前列腺增生症（BPH）合并心、脑、肺、肝、肾等疾病时．临床称为高危BPH。1999年5月～2005年12月，我们对74例高危BPH患者行经尿道前列腺汽化术（TUVP）联合经尿道前列腺电切术（TURP）治疗，疗效满意。现报告如下。     

经尿道前列腺电切术联合钬激光碎石术同期治疗前列腺增生伴膀胱结石

经尿道前列腺电切术(TURP)是目前公认治疗前列腺增生症(BPH)的"金标准".而对于BPH合并膀胱结石(LVC)的患者,治疗方法多,各家经验不一.我院从2005年12月至2007年12月同期行TURP及膀胱镜下钬激光碎石术治疗BPH合并VC患者62例,均获得成功.     

Early Results of Photoselective Vaporization of the Prostate in Medical Control‐failed Patients

Objectives: We present here our early results and learning curve for photoselective vaporization of the prostate (PVP) performed by an experienced urologist and we provide an analysis of the morbidity and early functional outcomes. Methods: Forty‐four patients were selected, from May 2006 to January 2009, who had benign prostate hyperplasia (BPH) accompanied by lower urinary tract symptoms (LUTS). After undergoing PVP for BPH at our hospital, the patients were followed up for approximately 2 years. PVP was performed by the same experienced urologist using potassium‐titanyl‐phosphate (KTP) laser. Baseline characteristics, preoperative and perioperative data, and postoperative complications were evaluated. Regular outpatient department follow‐up was conducted after patients were discharged from the hospital at 1, 4 and 12 weeks. Results: The mean age of the 44 patients was 71.6 years. The mean prostate volume was 47.52 mL. The mean PVP surgery time was 79.11 min. The mean urinary catheterization time was 23.41 h. Few complications arose after PVP, except that 47.7% of the patients developed pyuria after being discharged from hospital. The average hospital stay was 2.45 days. There were no significant differences in the efficiency of tissue vaporization among the patients. Conclusion: PVP for BPH has various advantages, including reducing postoperative complications. An experienced urologist can easily perform PVP. However, early results show no significant differences in the efficiency for the PVP technique.     

经尿道等离子前列腺剜除术治疗前列腺增生症的疗效分析

目的探讨经尿道前列腺等离子剜除术(TUPK-EP)治疗巨大良性前列腺增生(BPH)的疗效。方法入选2013年1月至2015年12月广州市增城区新塘医院泌尿外科收治的巨大BPH患者65例,依据治疗方法分为两组:经尿道前列腺等离子电切术(TUPK-RP)组(n=32)和TUPK-EP组(n=33)。对比两组患者的疗效、最大尿流量(Q_(max))及残余尿量(PVR)等临床指标。结果与TUPK-RP组相比,TUPK-EP组患者的手术时间显著缩短、冲洗液用量和术中出血量显著减少、Hb下降值亦显著降低,而腺体切除量显著增加,差异均具有统计学意义(P0.05)。术后3个月的复查结果显示,与TUPK-RP组相比,TUPK-EP组的Q_(max)显著增高、PVR显著降低,差异均具有统计学意义(P0.05)。结论在治疗巨大BPH时,与TUPK-RP比较,TUPK-EP的优势更明显,能更完全地切除腺体,缩短手术时间,降低术中出血量,值得临床推广应用。     

老年良性前列腺增生症单药治疗无效的危险因素

目的通过分析α-受体阻滞剂治疗老年良性前列腺增生症(BPH)无效的危险因素,明确初诊老年BPH的药物选择。方法回顾研究96例老年BPH患者,其中单用α-受体阻滞剂坦索罗新治疗组42例,与5α-还原酶抑制剂非那雄胺联合治疗组54例,比较两组国际前列腺症状评分(IPSS)、生活质量指数(QOL)、最大尿流速(Qmax)、残余尿量(PVR)、前列腺体积及血清前列腺特异性抗原(PSA)。结果联合用药与单药治疗组比较,前列腺体积、Qmax和IPSS具有统计学差异;多元回归分析显示IPSS(P<0.001)及前列腺体积(P<0.05)与老年BPH单药治疗无效密切相关。结论老年BPH患者单药及联合治疗均能改善病情,对于初诊时具有较高的IPSS评分及严重的前列腺体积增大者应给予药物联合治疗。     

非那雄胺对慢性心力衰竭合并良性前列腺增生老年男性患者的疗效

目的探讨非那雄胺对慢性心力衰竭（chronic heart failure,CHF）合并良性前列腺增生（benign prostatic hyperplasia．BPH）的老年男性患者的疗效。方法95例CHF合并BPH老年男性按数字表法随机分为治疗组及对照组,两组均根据患者的心功能情况规范使用抗心力衰竭治疗。治疗组使用非那雄胺,对照组使用安慰剂治疗2年。观察两组前列腺体积、国际前列腺症状评分表（IPSS）评分、BPH患者生活质量（QOL）评分、肌酐、血尿素氮、N末端脑钠肽前体、肌钙蛋白、左心室射血分数（LVEF）、急性尿潴留、需手术干预、心血管事件、心力衰竭再住院率、心功能的变化及主要副作用等指标,并进行比较。结果治疗组心血管事件发生率[23．25％（10／43）／35．47．61％（20／42）,P〈0．05]、心力衰竭再住院率[25．58％（11／43）vs50．00％（21／42）,P〈O．05]、急性尿潴留率[13．95％（6／43）vs42．85％（18／42）,P〈0．05]、需手术干预率[16．27％（7／43）／iS．52．38％（22／42）,P〈0．051,明显低于对照组,差异有统计学意义。治疗组前列腺体积、国际前列腺症状评分表评分及肌酐、N末端脑钠肽前体浓度低于对照组,差异有统计学意义（P〈O．05）。两组治疗2年后在勃起功能障碍、性欲减退、乳腺增大、乳腺疼痛的发生率比较,差异无统计学意义（P〉0．05）。结论对于CHF合并BPH的患者在规范的治疗心力衰竭的基础上应尽早长期使用非那雄胺,可显著降低患者的主要心血管事件发生率、心力衰竭再次住院率、急性尿潴留率、需手术干预率,缩小前列腺体积,改善下尿道症状及患者生活质量,而无明显增加副作用。     

Effect of tricuspid annuloplasty on the clinical course following mitral or aortic valve operation

To assess the effect of additional tricuspid annuloplasty during mitral/aortic valve surgery on the clinical postoperative course in patients with severe preoperative tricuspid insufficiency, 64 patients were investigated pre- and 11 +/- 4 months postoperatively. Extent of left-side heart failure was graded as well as severity of right-side heart failure using a defined clinical score. Using preoperative biplane angiography of the right ventricle the patients were assigned to three different groups: group I (n = 30) with no preoperative tricuspid insufficiency (TI), group II (n = 19) with preoperative TI and without tricuspid annuloplasty, group III (n = 15) with preoperative TI and with annuloplasty of the tricuspid valve. The patients of all three groups postoperatively improved from an average of NYHA class III to class II. The clinical score of right-side heart failure in gr. III and gr. II was 1.4 +/- 1.0 and 1.5 +/- 1.0, respectively, and was significantly (p less than 0.05) higher than in gr. I (0.8 +/- 0.8). In all three groups there was a postoperatively significant decrease: gr. I: 0.3 +/- 0.5 (p less than 0.01); gr. II: 0.6 +/- 0.9 (p less than 0.02); gr. III: 0.7 +/- 0.8 (p less than 0.05). Mortality was 3% in gr. I; 5% in gr. II and 6% in gr. III. 3% of patients in gr. I, 30% in gr. II and 6% in gr. III had early postoperative hemodynamic complications.(ABSTRACT TRUNCATED AT 250 WORDS)     

代谢综合征对老年人良性前列腺增生病程的影响

目的 探讨代谢综合征(MS)在老年人良性前列腺增生(BPH)病程中的作用.方法 101例BPH患者分为单纯BPH组45例与合并MS的BPH组56例,分析体质量指数(BMI)、腰围、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBS)、胰岛素抵抗指数(HOMA-IR)等代谢性因素对BPH患者前列腺体积(PV)、血清前列腺特异性抗原(PSA)、国际前列腺症状评分(IPSS)、下尿路症状(LUTS)出现时间的影响.结果 合并MS的BPH患者PV明显大于单纯BPH患者(t=3.22,P=0.003),LUTS出现时间长于后者(t=2.02,P=0.046).超重和肥胖的BPH患者PV明显大于正常体质量组[分别为(49.44±26.83)ml与(38.10±10.64)ml,P=0.021;(51.7±22.2)ml与(38.10±10.64)ml,P=0.043];腹型肥胖的BPH组患者PV明显大于非腹型肥胖的BPH患者组[(50.26±26.51)ml与(38.99±11.25)ml,P=0.005].低HDL-C水平组PV明显大于正常HDL-C水平组[(54.23±28.92)ml与(40.40±14.87) ml,P=0.009].FBS水平异常的BPH患者PV、PSA水平超过正常FBS水平者(t=3.17,2.41; P=0.035,0.013).合并胰岛素抵抗的BPH患者的PV明显大于胰岛素敏感者(t=3.43,P=0.001),LUTS出现时间在胰岛素抵抗组明显延长(t=3.58,P=0.001).PV与BMI (r=0.46,P=0.000)、FINS (r=0.42,P=0.001)、HOMA-IR (r=0.49,P=0.003)呈正相关;而与HDL-C(r=-0.38,P=0.000)呈负相关.多元逐步回归分析显示PV与HOMA-IR关系最密切.结论 MS对BPH的病程和发展具有明显的影响.     

The use of esmolol in patients with myocardial infarction complicated with acute left ventricular failure

Forty patients with acute Q-wave myocardial infarction and Killip class I-II heart failure were randomized to treatment with esmolol (n=22) or just to standard therapy (n=18) and followed up for 30 days. Esmolol treated patients had significantly lower in-hospital mortality (p<0.02), less frequently had postinfarction angina (p<0.05) and heart failure progression (p<0.01) and demonstrated significant decrease of brain natriuretic peptide level (by 25%, p<0.05). Incidence of heart rhythm disturbances and values of parameters of echocardiogram were similar in both groups.     

Evidence for Modulation of Melatonin Secretion in Men With Benign and Malignant Tumors of the Prostate: Relationship With the Pituitary Hormones

The serum levels of the pineal hormone melatonin were determined by radioimmunoassay (RIA) in 4-h intervals throughout a 24-h period in elderly men with different types of prostate tumors: benign prostatic hyperplasia (BPH, n = 13), incidental carcinoma (PCi, n = 5), and nonmetastasizing carcinoma (PC, n = 9), as well as in young men (YM, n = 10). Simultaneously, the pituitary hormones prolactin, growth hormone, luteinizing hormone and follicle-stimulating hormone were measured by RIA. All subjects were untreated and free of serious complaints, and they stayed in the same environment. The data were analyzed by the population mean-cosinor method, and linear correlation coefficients between the five hormones were calculated for each group. Melatonin showed significant circadian rhythms in young men and patients with BPH and PCi but not in patients with PC. Twenty-four-hour mean concentration (mesor) and amplitude were significantly increased in patients with PCi as compared to patients with PC. Prolactin showed significant circadian rhythms in young men and in patients with BPH, whereas patients with PCi and PC appeared to have ultradian variations. Growth hormone did not show significant rhythms in any of the groups; the mesors were elevated in all tumor groups as compared to young men. Gonadotropin mesors were elevated in all tumor patients as compared to young men; rhythms were not detected. Carcinoma patients showed different interhormonal correlations than all other groups. These results indicate that modulation of melatonin secretion, accompanied by changes in the pituitary hormone levels, may be related to development and growth of prostate cancer.     

八味通络颗粒治疗舒张性心力衰竭30例临床观察

目的观察八味通络颗粒治疗舒张性心力衰竭的临床疗效。方法将60例舒张性心力衰竭患者随机分为对照组和治疗组,每组30例,两组均给予常规西药治疗,治疗组加用八味通络颗粒,疗程8周。观察治疗后两组纽约心脏病学会(NYHA)心功能疗效、中医证候疗效,以及治疗前后超声心动图反映的左室舒张功能指标,包括二尖瓣舒张早期血流峰值速度(E)、舒张晚期血流峰值速度(A)、E/A比值、等容舒张时间(IVRT)、E峰加速时间(ACTe)和E峰减速时间(DCTe)。结果治疗后两组NYHA心功能疗效比较无统计学意义(P>0.05),中医证候疗效比较有统计学意义(P<0.05)。超声心动图比较,治疗组治疗后E、A、E/A、IVRT及DCTe与治疗前比较有统计学意义(P<0.05);与对照组比较,治疗后治疗组A、DCTe明显降低(P<0.05),E/A明显增加(P<0.05)。结论八味通络颗粒能明显改善反映左室舒张功能的超声指标,可提高中医证候疗效。     

经尿道柱状水囊前列腺扩开术治疗高危老年前列腺增生患者的分析

目的研究经尿道柱状水囊前列腺扩开术(TUDP)治疗老年良性前列腺增生(BPH)高危患者的临床疗效及安全性。方法入选2015年1月至2016年10月在眉山市中医医院外三科拟实施手术治疗的老年BPH高危患者100例,随机数字表法分为经尿道前列腺等离子双极电切术(BP-TURP)组和TUDP组,每组50例,研究两种术式用于老年BPH高危患者的临床疗效和安全性。结果相比BP-TURP组,TUDP组患者的手术时间、手术出血量、尿管留置时间、术后住院时间缩短,差异有统计学意义(P0.05)。两组患者治疗前、治疗3个月后的国际前列腺症状评分(IPSS)、残余尿量(RUV)、生活质量评分(QOL)和最大尿流率(Qmax)差异无统计学意义(P0.05)。两组患者的血尿、尿道狭窄、暂时性尿失禁等并发症的发生差异无统计学意义(P0.05)。结论 TUDP具有手术创伤小、术后恢复快的优势,可用于老年BPH高危患者。