反应停抗肿瘤作用研究进展

肿瘤的生长有赖于血管生成，血管生成是肿瘤侵袭、转移的基础。抑制血管生成可使肿瘤萎缩坏死或使微转移灶长期处于“休眠”状态。反应停于上世纪中叶作为非巴比妥类镇静剂用于早孕反应，后曾因严重的致畸作用而被禁用。近年研究发现．反应停能明显抑制兔角膜血管生成，具有血管生成抑制作用，因而被应用于肿瘤研究。然而，实验研究中反应停对实体瘤的抗肿瘤效应并不一致，作用机制也未完全明了。我们对反应停药理作用、抗肿瘤效用、作用机制及临床应用等方面的研究进展予以综述。     

反应停的新生—抗肿瘤

抗肿瘤血管生成是现在肿瘤治疗研究的热点之一，研究发现曾因严重致畸作用而被禁用的反应停具有明显的抗血管生成作用，因此被用于抗肿瘤的研究。动物实验和临床试验都得到了一些令人鼓舞的结果，发现反应停对多种肿瘤具有明显的疗效，预示反应停将有可能在抗肿瘤领域获得新生。     

反应停抗肿瘤作用研究进展

肿瘤的生长有赖于血管生成,血管生成是肿瘤侵袭、转移的基础。抑制血管生成可使肿瘤萎缩坏死或使微转移灶长期处于“休眠”状态。反应停于上世纪中叶作为非巴比妥类镇静剂用于早孕反应,后曾因严重的致畸作用而被禁用。近年研究发现,反应停能明显抑制兔角膜血管生成,具有血管生成抑制作用,因而被应用于肿瘤研究。然而,实验研究中反应停对实体瘤的抗肿瘤效应并不一致,作用机制也未完全明了。我们对反应停药理作用、抗肿瘤效用、作用机制及临床应用等方面的研究进展予以综述。     

反应停的新生--抗肿瘤

抗肿瘤血管生成是现在肿瘤治疗研究的热点之一,研究发现曾因严重致畸作用而被禁用的反应停具有明显的抗血管生成作用,因此被用于抗肿瘤的研究.动物实验和临床试验都得到了一些令人鼓舞的结果,发现反应停对多种肿瘤具有明显的哪疗效,预示着反应停将有可能在抗肿瘤领域获得新生.     

抗血管生成药治疗肝细胞癌的研究进展

肝细胞癌（HCC）是一种血管丰富的癌症，抗血管生成药可通过阻断血管生成因子，抑制内皮细胞扩增及预防细胞外基质和血管基底膜降解等机制而发挥治疗肝癌的作用，加上其临床相对优良的安全性可能为肝癌治疗提供了治疗新途径。     

反应停在实体肿瘤中的应用

反应停是一种口服的抗血管生成和免疫调节剂，在进展期肿瘤中已进行了大量的试验研究，证实其在血液恶性肿瘤治疗中有显著作用；而对实体肿瘤稍显逊色．研究发现反应停对肾癌、前列腺癌、恶性黑色素瘤作用较明显，尤其与生物制剂或化疗药物联合作用更突出；而对头颈部肿瘤、乳腺癌作用不明显。文章就反应停在实体肿瘤治疗方面的应用作一综述。     

肝癌血管生成的研究

肝癌是比较典型的多血管肿瘤,其生长和转移依赖肿瘤血管生成。栓塞已有的血管(肝动脉栓塞化疗),和阻断血管生成(索拉菲尼)的治疗已是临床标准的肝癌治疗方法。最近的证据显示侵袭性较强的肝癌可在癌周诱导特殊的环境     

肿瘤血管生成抑制物作用机制及应用研究进展

介绍肿瘤血管生成抑制物血管抑素、内皮抑素、CM-101、TNP-470、反应停、血小板因子-4、白介素-12和基质金属蛋白酶抑制剂等的作用机制应用研究进展.     

肿瘤血管生成抑制物作用机制及应用研究进展

介绍肿瘤血管生成抑制物血管抑素、内皮抑素、CM－101、TNP－470、反应停、 血小板因子－4、白介素－12和基质金属蛋白酶抑制剂等的作用机制应用研究进展。     

反应停治疗乳腺癌的研究进展

乳腺癌的生长、转移与复发是血管生成依赖的，故以肿瘤血管生成的各个环节及其发生过程中的生化改变为靶点，研制血管生成抑制剂，可有效地抑制肿瘤生长、侵袭、转移和复发。近年来随着动物及体外和体内实验发现反应停(酞咪哌啶酮，thalidomide)具有抑制血管生成及抗肿瘤的潜能等作用，特     

Ringworm in animals in a farm in Assiut

Bericht über das Auftreten von Hautmykosen bei Tieren auf der Farm der Landwirtschaftlichen Fakultät der Universität Assiut. Von 70 Kälbern waren 42 pilzkrank, davon 22 durch T. mentagrophytes, 20 durch T. verrucosum. Von 180 Kühen waren 8 pilzbefalien, sämtlich durch T. mentagrophytes. Von 2 kranken Bullen wurde T. verrucosum isoliert. Auch die 3 Pferde und 2 Maultiere der Farm waren pilzinfiziert; Erreger war in diesen Fällen T. equinum. Auch ein Kalb war von T. equinum befallen. Die gleiche Pilzart wurde ferner von 3 Tierpflegern isoliert, die Pilzherde am Hals und an den Armen aufwiesen.     

Statistical challenges in preprocessing in microarray experiments in cancer

Many clinical studies incorporate genomic experiments to investigate the potential associations between high-dimensional molecular data and clinical outcome. A critical first step in the statistical analyses of these experiments is that the molecular data are preprocessed. This article provides an overview of preprocessing methods, including summary algorithms and quality control metrics for microarrays. Some of the ramifications and effects that preprocessing methods have on the statistical results are illustrated. The discussions are centered around a microarray experiment based on lung cancer tumor samples with survival as the clinical outcome of interest. The procedures that are presented focus on the array platform used in this study. However, many of these issues are more general and are applicable to other instruments for genome-wide investigation. The discussions here will provide insight into the statistical challenges in preprocessing microarrays used in clinical studies of cancer. These challenges should not be viewed as inconsequential nuisances but rather as important issues that need to be addressed so that informed conclusions can be drawn.     

Trends in zygomycosis in children

Zygomycosis, or mucormycosis, is associated with significant morbidity and mortality in both children and adults. Studies in adults have shown an increase in the incidence of zygomycosis, particularly among haemtopoietic stem cell transplant (HSCT) recipients and patients with haematologic malignancies. There is a paucity of data on the epidemiology of zygomycosis in children. We performed a retrospective analysis to describe trends in zygomycosis between 1 January 2003 and 31 December 2010. We used the Pediatric Health Information System (PHIS) database to identify paediatric patients who were diagnosed with zygomycosis during the study period. Administrative data on diagnoses, demographics, underlying conditions and clinical experiences were collected. Summary statistics were calculated and tests for trend were conducted. We identified 156 unique patients with zygomycosis. The prevalence of zygomycosis did not significantly increase over time (P=0.284). The most common underlying condition was malignancy (58%) and over half received intensive care. Voriconazole utilisation among all hospitalised children significantly increased during the period (P=0.010). Our study demonstrates that the incidence of zygomycosis is not significantly increasing. During the time period there was a significant increase in the use of voriconazole among children.     

Sex hormones in women in rural China and in Britain

Plasma concentrations of certain hormones linked to breast cancer risk were measured in age-pooled samples from 3,250 rural Chinese women in 65 counties, and 300 British women, all aged 35-64. In age-groups 35-44, 45-54 and 55-64 respectively, mean oestradiol concentrations were 36% (P = 0.043), 90% (P less than 0.001) and 171% (P = 0.001) higher in the British than in the Chinese women, and mean testosterone concentrations were 48% (P less than 0.001), 68% (P less than 0.001) and 53% (P = 0.001) higher in the British than in the Chinese women. The difference in testosterone concentrations between the two countries appeared to be due largely to the lower average body weight in the Chinese women. Sex hormone binding globulin did not differ significantly between the two countries in age groups 35-44 and 45-54, but was 15% (P = 0.002) lower in the British than in the Chinese women at ages 55-64. Prolactin concentrations did not differ significantly between the two countries in any age group.     

Hemoglobin in lymphogranulomatosis in children

The peculiarities of hemoglobin content and properties in lymphogranulomatosis were studied in children by different methods. In most patients the content of fetal hemoglobin and methhemoglobin was found to increase and the rate of ferricyanide oxidation of hemoglobin also increases. Simultaneously, the rate of non-homogenicity of basic hemoglobin fractions was observed to increase on account of immunologically different components.     

Dermatomycosis in Goats in India

Summary: In an extensive survey involving 2176 goats 1.56% of goats manifested clinical lesions of ringworm infection. Animals below the age of 6 months were affected most (4.20%). The incidence of infection was higher during the winter months. T. verrucosum, T. mentagrophytes and M. gypseum were isolated from the skin scrapings of 12, 4, and 2 goats respectively. It is suggested that the infected animals could be a source of disease to human population in which the zoophilic dermatophyte invasion is characterized by severe inflammatory lesions of the skin. The zoonotic importance of different dermatophytes is stressed.
Zusammenfassung: In einer ausgedehnten Untersuchung an 2176 Ziegen wurden bei 1,56% klinische Zeichen einer Hautmykose festgestellt. Tiere, die jühger als 6 Monate alt waren, zeigten mit 4,20% am häfigsten Krankheitssymptome. In den Wintermonaten war die Erkrankungshäufigkeit am gröBten. T. vermcosum, T. mentagrophytes and M. gypseum wurden jeweils von 12,4 bzw. 2 Ziegen isoliert. Die inflzierten Tiere köinnen eine Infektionsquelle für die menschliche Bevölkerung darstellen und dort Mykosen mit stark entzündlichen Veränderungen auslösen. Die Bedeutung verschiedener Dermatophyten als Erreger von Zoonosen wird hervorgehoben.