ISOLATION AND CHARACTERIZATION OF AN ADRIAMYCIN－RESISTANT SUBLINE OF THE HUMAN GASTRIC ADENOCARCINOMA CELLLINE

ＩＳＯＬＡＴＩＯＮＡＮＤＣＨＡＲＡＣＴＥＲＩＺＡＴＩＯＮＯＦＡＮＡＤＲＩＡＭＹＣＩＮ－ＲＥＳＩＳＴＡＮＴＳＵＢＬＩＮＥＯＦＴＨＥＨＵＭＡＮＧＡＳＴＲＩＣＡＤＥＮＯＣＡＲＣＩＮＯＭＡＣＥＬＬＬＩＮＥＷａｎｇＹａｎｐｉｎｇ；王艳萍；ＸｕＧａｎｇ；徐刚（Ｉ...     

QUALITATIVE STUDY OF SIALOMUCINS CHANGES DURING N－METHYL－N－NITROSOUREA－INDUCED C OLONIC CARCINOGENESIS IN MICE

ＱＵＡＬＩＴＡＴＩＶＥＳＴＵＤＹＯＦＳＩＡＬＯＭＵＣＩＮＳＣＨＡＮＧＥＳＤＵＲＩＮＧＮ－ＭＥＴＨＹＬ－Ｎ－ＮＩＴＲＯＳＯＵＲＥＡ－ＩＮＤＵＣＥＤＣＯＬＯＮＩＣＣＡＲＣＩＮＯＧＥＮＥＳＩＳＩＮＭＩＣＥＷａｎｇＱｉａｎｇ王强；ＷａｎｇＹｕａｎｈｅ王元和；...     

RELATIONSHIP BETWEEN THE MUTATION OF P53 GENE AND INFILTRATION，METASTASIS AND PROGNOSIS OF GASTRIC CARCINOMA

ＲＥＬＡＴＩＯＮＳＨＩＰＢＥＴＷＥＥＮＴＨＥＭＵＴＡＴＩＯＮＯＦＰ５３ＧＥＮＥＡＮＤＩＮＦＩＬＴＲＡＴＩＯＮ，ＭＥＴＡＳＴＡＳＩＳＡＮＤＰＲＯＧＮＯＳＩＳＯＦＧＡＳＴＲＩＣＣＡＲＣＩＮＯＭＡＸｉｎＹａｎ辛彦；ＺｈａｏＦｅｎｇｋａｉ赵凤凯；ＷｕＤｏｎｇ...     

STUDIES ON THE GAP JUNCTIONAL INTERCELLULARCOMMUNICATION OF HUMAN NASOPHARYNGEALCARCINOMA CELLS AND THE EFFECT OF RII

ＳＴＵＤＩＥＳＯＮＴＨＥＧＡＰＪＵＮＣＴＩＯＮＡＬＩＮＴＥＲＣＥＬＬＵＬＡＲＣＯＭＭＵＮＩＣＡＴＩＯＮＯＦＨＵＭＡＮＮＡＳＯＰＨＡＲＹＮＧＥＡＬＣＡＲＣＩＮＯＭＡ　ＣＥＬＬＳＡＮＤＴＨＥＥＦＦＥＣＴＯＦＲＩＩＨａｎＬｉｑｕｎ韩立群；ＧａｏＪｉｎ高进；...     

INVESTIGATION OF RELATIONSHIPS BETWEEN KI－67SCORE，DNA INDEX，AND HISTOLOGIC GRADEIN SOFT TISSUE SARCOMAS

ＩＮＶＥＳＴＩＧＡＴＩＯＮＯＦＲＥＬＡＴＩＯＮＳＨＩＰＳＢＥＴＷＥＥＮＫＩ－６７ＳＣＯＲＥ，ＤＮＡＩＮＤＥＸ，ＡＮＤＨＩＳＴＯＬＯＧＩＣＧＲＡＤＥＩＮＳＯＦＴＴＩＳＳＵＥ　ＳＡＲＣＯＭＡＳＷａｎｇｙａｎｏｎｇ王亚农；ＳｈｉＤａｒｅｎ施达仁；ＳｈｅｎＺ...     

PROMOTION OF CHEMICAL CARCINOGENESIS AND P53 EXPRESSION BY REDUCTION OF SUPEROXIDE DISMUTASE ACTIVITY IN THE LUNG OF RAT IN V

ＰＲＯＭＯＴＩＯＮＯＦＣＨＥＭＩＣＡＬＣＡＲＣＩＮＯＧＥＮＥＳＩＳＡＮＤＰ５３ＥＸＰＲＥＳＳＩＯＮＢＹＲＥＤＵＣＴＩＯＮＯＦＳＵＰＥＲＯＸＩＤＥＤＩＳＭＵＴＡＳＥＡＣＴＩＶＩＴＹＩＮＴＨＥＬＵＮＧＯＦＲＡＴＩＮＶＩＶＯ￥ＹｕＬｕｎｙｉｎ；喻伦银；Ｂｉ...     

GST-π EXPRESSION IN TRANSFORMED CELLS BY TRANSFECTING OF DNA ISOLATED FROM HUMAN FETAL LUNG TISSUES TREATED WITH CARCINOGENS

ＧＳＴπＥＸＰＲＥＳＳＩＯＮＩＮＴＲＡＮＳＦＯＲＭＥＤＣＥＬＬＳＢＹＴＲＡＮＳＦＥＣＴＩＮＧＯＦＤＮＡＩＳＯＬＡＴＥＤＦＲＯＭＨＵＭＡＮＦＥＴＡＬＬＵＮＧＴＩＳＳＵＥＳＴＲＥＡＴＥＤＷＩＴＨＣＡＲＣＩＮＯＧＥＮＳＹａｏＤｅｎｇｇａｏ姚登高ＨｕＧｕ...     

INVESTIGATION OF BLOOD SUPPLY OF BRONCHOGENIC CARCINOMA DERIVING FROM PULMONARY ARTERY

ＩＮＶＥＳＴＩＧＡＴＩＯＮＯＦＢＬＯＯＤＳＵＰＰＬＹＯＦＢＲＯＮＣＨＯＧＥＮＩＣＣＡＲＣＩＮＯＭＡＤＥＲＩＶＩＮＧＦＲＯＭＰＵＬＭＯＮＡＲＹＡＲＴＥＲＹＺｈｅｎｇＲｕｈｅｎｇ郑如恒ＤｏｎｇＹｏｎｇｈｕａ董永华ＺｈｏｕＫａｎｇｒｏｎｇ周康荣（Ｄｅｐａｒ...     

CONGENITAL EXPRESSION OF mdr-1 GENE IN FRESH CANCER TISSUES FROM SEVERAL HIGH-INCIDENCE NEOPLASMS WITHOUT PREOPERATIVE CHEMOTHERAPY

ＣＯＮＧＥＮＩＴＡＬＥＸＰＲＥＳＳＩＯＮＯＦｍｄｒ１ＧＥＮＥＩＮＦＲＥＳＨＣＡＮＣＥＲＴＩＳＳＵＥＳＦＲＯＭＳＥＶＥＲＡＬＨＩＧＨＩＮＣＩＤＥＮＣＥＮＥＯＰＬＡＳＭＳＷＩＴＨＯＵＴＰＲＥＯＰＥＲＡＴＩＶＥＣＨＥＭＯＴＨＥＲＡＰＹＺｈａｎｇＹａｎｍ...     

EXPRESSION OF ONCOGENES DURING INDUCED DIFFERENTIATION OF HUMAN HEPATOCARCINOMA CELL LINE

ＥＸＰＲＥＳＳＩＯＮＯＦＯＮＣＯＧＥＮＥＳＤＵＲＩＮＧＩＮＤＵＣＥＤＤＩＦＦＥＲＥＮＴＩＡＴＩＯＮＯＦＨＵＭＡＮＨＥＰＡＴＯＣＡＲＣＩＮＯＭＡＣＥＬＬＬＩＮＥＣｈａｉＸｉｙｕｎ柴希运ＣｈｅｎＨｕｉｌｉ陈惠黎（ＤｅｐａｒｔｍｅｎｔｏｆＢｉｏｃｈｅｍｉｓ...     

Cohort study on association of smoking and air pollution with lung cancer among 210,000 persons in shanghai

Survey on smoking habit and other related factors has been carried out among 110,000 persons in urban area and 100,000 persons in suburb and outer suburb area. The degrees of air pollution among three areas are different and the urban area is the one with the heaviest degree and the outer suburb with the lowest. Study on the relationship between smoking, air pollution and lung cancer has been carried out among the residents with the age of 40 years old and over in the three areas. The subjects were followed up for six years in urban area and five years in suburb and outer suburb. The total number of lung cancer death found in this period was 828. Most of these diagnosis were classified as group of high (I or II) degree. For nonsmokers, there were no significant differences of standardized mortality radio (SMR) of lung cancer among three areas. For male smokers, the highest SMR of lung cancer was seen in urban area, the lowest in outer suburb and these differences reached the significant lever. Cigarette smoking was significantly associated with increased risk of lung cancer by comparing the data between smokers and non-smokers in the three areas. Also, it was showed that the combiend effect of smoking with air pollution probably existed. The age-specific mortality rates for lung cancer among non-smokers in Shanghai urban were much higher than those in West Europe and North America, which indicated that risk factors other than smoking may exist.     

Smoking, air pollution, and the high rates of lung cancer in Shenyang, China

A case-control study involving interviews with 1,249 patients with lung cancer and 1,345 population-based controls was conducted in Shenyang, an industrial city in northeastern China, where mortality rates are high among men and women. Cigarette smoking was found to be the principal cause of lung cancer in this population, accounting for 55% of the lung cancers in males and 37% in females. The attributable risk percentage among females is high compared to elsewhere in China, largely because of a higher prevalence of smoking among women. After adjustment for smoking, there were also significant increases in lung cancer risk associated with several measures of exposure to air pollutants. Risks were twice as high among those who reported smoky outdoor environments, and increased in proportion to years of sleeping on beds heated by coal-burning stoves (kang), and to an overall index of indoor air pollution. Threefold increases in lung cancer risk were found among men who worked in the nonferrous smelting industry, where heavy exposures to inorganic arsenic have been reported. The associations with both smoking and indoor air pollution were stronger for squamous cell and small cell carcinomas than for adenocarcinoma of the lung. Risks due to smoking or air pollution were not greatly altered by adjustment for consumption of fresh vegetables or sources of beta carotene or retinol, prior chronic lung diseases, or education level. The findings suggest that smoking and environmental pollution combine to account for the elevated rates of lung cancer mortality in Shenyang.     

2016年重庆市肺癌发病率、死亡率与生存率分析

目的:分析2016年重庆市肺癌发病率、死亡率与随访五年的生存率,为开展肺癌防治提供依据。方法:对2016年新报告的肺癌患者进行主动和被动随访,随访信息网络直报到重庆市肿瘤随访登记信息系统,采用SPSS 25.0统计分析发病率、标化发病率、死亡率、标化死亡率、生存率等指标。标化发病率与死亡率采用2000年第五次人口普查标准人口构成进行标化。不同性别与地区率的比较采用χ2检验。采用生存分析寿命表法计算观察生存率,采用乘积极限法(Kaplan-Meier)计算平均生存时间,生存率的比较采用Log Rank of Mantel-Cox进行统计检验。结果:2016年重庆市肺癌发病率与标化发病率分别为79.13/10万与44.82/10万,男性发病率（110.33/10万）高于女性（46.77/10万）（χ2=63.018,P<0.001）,城市（87.65/10万）高于农村（75.86/10万）（χ2=10.47,P=0.001）。肺癌死亡率与标化死亡率分别为65.96/10万与33.77/10万,男性死亡率（95.40/10万）高于女性（35.95/10万）（χ2=64.43,P<0.001）,城市（73.30/10万）高于农村（60.83/10万）（χ2=12.28,P<0.001）。对18 842例肺癌患者进行五年的随访,随访五年平均生存时间为2.11（2.07,2.14）年。1年、2年、3年、4年、5年生存率分别为41.84%、33.41%、29.97%、28.04%、26.54%,女性肺癌生存率均高于男性,差异有统计学意义（χ2=80.05,P<0.001）。城市肺癌生存率均高于农村,差异有统计学意义（χ2=271.78,P<0.001）。 结论:重庆市肺癌发病率和死亡率高,生存率较低,重点应针对男性和农村地区开展肺癌的预防、早期筛查和规范的诊断治疗。     

肺癌与大气污染关系的流行病学研究进展

随着我国肺癌负担的不断增加,对其危险因素的探讨显得十分迫切.环境污染,尤其室外空气污染可能在肺癌的发病和死亡过程中起重要作用.本文收集最近10年国内外相关文献,筛选出关于肺癌和室外空气污染的流行病学研究,并归纳不同地区主要的室外空气污染物对肺癌发病和死亡的影响,罗列出如气象因素、社会经济学状况、吸烟、职业等可能的混杂因素,为未来的相关研究提供信息.     

香港女性肺癌,空气污染抑或饮食？：饮食,空气污染与肺癌关系的混杂因素

从世界范围来说，住在香港、夏威夷、旧金山和新加坡的华裔妇女肺癌发病率相对较高，然而吸烟率低。过去１５年我们以室内空气污染（ＥＴＳ，烧香，烹调污染）为重点，并以饮食为可能因素来探讨它们与肺癌的关系，但未发现这些空气污染物与肺癌有联系。吸烟者（吸烟量已作了调整）即使有４０年以上烧香史，肺癌危险性仍下降了８３％（趋势检验Ｐ＝０．０１）。不吸烟妇女（年龄、生育史、文化程度已调整）从事烹调即使超过４０年，肺癌危险性仍下降６３％（Ｐ＝０．００１）。可见结果与预期相反，但可用饮食因素来解释。吸烟者中烧香的妇女往往比不烧香的妇女喜欢吃“健康饮食”；不吸烟者参与烹调多年的妇女也更喜欢吃“健康饮食”。健康饮食是指较多吃鲜鱼、蔬菜、水果和较少吃经防腐处理过的食品、辣酱和饮酒，前类食物使香港华人妇女肺癌危险性降低，后者则使之增高，可见饮食因素起着混杂因子的作用，使评价空气污染对肺癌危险性的影响蒙上阴影     

Decrease in Risk of Lung Cancer Death in Males after Smoking Cessation by Age at Quitting: Findings from the JACC Study

To evaluate the impact of smoking cessation in individuals and populations, we examined the decrease in risk of lung cancer death in male ex-smokers by age at quitting in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study), which was initiated from 1988 to 1990 in Japan. For simplicity, subjects were limited to male non-smokers, and former/current smokers who started smoking at ages 18-22, and 33 654 men aged 40-79 years were included. We modeled the mortality rates in non-smokers and current smokers, and compared the rates in ex-smokers with those expected from the model if they had continued smoking. During the mean follow-up of 8.0 years, 341 men died from lung cancer. The mortality rate ratio for current smokers, compared to non-smokers, was 5.16, and those for ex-smokers who had quit smoking 0-4, 5-9,10-14,15-19 and >20 years before were 4.84, 3.19, 2.03,1.29 and 0.99, respectively. The functions of 3.20×l0^-7×(age)⁴⁵ and 1.96×lO^-5×(age-29.6)^4.5 fitted the observed mortality rates (per 100 000 person-years) in non-smokers and continuing smokers, respectively. A greater decrease in lung cancer mortality was estimated among those who quit smoking at younger ages. Stopping smoking earlier in life appears preferable to keep the individual risk low. The absolute rate, however, substantially decreased after smoking cessation even in those who quit at ages 60-69, reflecting the high mortality rate among continuing smokers in the elderly.     

2004～2005年西藏自治区恶性肿瘤死因调查分析

[目的]分析西藏自治区2004～2005年恶性肿瘤死亡分布特点和流行趋势.[方法]抽取2004～2005年全国第3次死因回顾调查西藏自治区1市4县恶性肿瘤死亡资料,覆盖总人年数为388 626人年,其中男性188 269人年,女性200 357人年.按性别和地区分别计算粗死亡率、肿瘤死因构成比、年龄别构成比、中国人口标化死亡率、世界人口标化死亡率和肿瘤死因顺位.并与第1次全国死因回顾调查(1973～1975年)资料比较.[结果] 2004～2005年共调查西藏自治区恶性肿瘤死亡病例250例,粗死亡率为64.33/10万,中标率为50.94/10万,世标率为63.70/10万.男性死亡率高于女性死亡率,男性合计粗死亡率为77.55/10万,女性为51.91/10万.男性最常见恶性肿瘤包括胃癌、肝癌、肺癌、食管癌和结直肠癌,前7位合计占男性恶性肿瘤死亡的94.52%;女性最常见恶性肿瘤包括胃癌、肝癌、食管癌、宫颈癌和乳腺癌,前8位合计占女性恶性肿瘤死亡的93.27%.城市和农村地区的死亡癌谱有较大差异,城市地区恶性肿瘤死亡前3位为胃癌、肝癌和肺癌,农村地区死亡前3位为胃癌、肝癌和食管癌.与70年代相比,城市和农村的胃癌、食管癌和结直肠癌粗死亡率水平呈下降趋势,肝癌和肺癌粗死亡率均呈上升趋势.[结论]西藏自治区恶性肿瘤死亡率低于全国和西部地区平均水平,胃癌和肝癌仍然是影响西藏人口最主要的肿瘤死因.     

江苏省肺癌死亡和大气污染情况地理信息系统的相关性

[目的]探讨肺癌死亡和大气污染程度之间的关系。[方法]收集江苏省1996年～1998年间肺癌死亡资料和同期的空气质量资料，利用地理信息系统的空间预测功能，分别作出江苏省肺癌死亡和大气污染情况的空间地理分布图，并在此基础上作相关分析。[结果]发现在大气污染严重的地区，肺癌死亡率也较高；经统计学分析发现预测的各地区：NOx浓度和肺癌标化死亡率之间相关有显著性。[结论]大气污染和肺癌死亡之间存在一定的关联因素，控制大气污染将是减少肺癌死亡的一项重要干预措施。     

身体质量指数和上海市男性肺癌关系的前瞻性队列研究

目的：研究身体质量指数(BMI)和男性肺癌之间的关系。方法：采用前瞻性队列研究方法，1986～1989年在上海市区建立了1个包括18000人的男性队列，以后每年随访1次，至2000年7月共收集到肺癌新发病例374人。结果：身体质量指数越高，患肺癌的危险性越低。以身体质量指数五分位的最低组作参比，调整了年龄、文化程度和吸烟情况等混杂因素后，其它4组的相对危险度依次为0．8、0．8、0．6和0．7，趋势检验P值=0．002。按吸烟状况进行分层分析后发现在当前吸烟者中，身体质量指数和患肺癌危险性的负相关关系依然存在，但是在从不吸烟组中，由于肺癌发病例数太少，目前还无法得出结论。按肺癌的不同组织学类型进行分析，发现身体质量指数和肺腺癌的关系较明显。结论：身体质量指数可能与上海男性肺癌危险性之间存在负相关关系。     

Smoking-attributable cancer mortality in 1991: is lung cancer now the leading cause of death among smokers in the United States?

Findings from the new American Cancer Society prospective study of 1.2 million men and women indicate that mortality risks among smokers have increased substantially for most of the eight major cancer sites causally associated with cigarette smoking. Lung cancer risk for male smokers doubled, while the risk for females increased more than fourfold. On the basis of the new American Cancer Society relative risks, we project that cigarette smoking alone will contribute to slightly more than 157,000 of the 514,000 total cancer deaths expected to occur in the United States in 1991. Overall, smoking directly contributes to 21.5% of all cancer deaths in women but 45% of all cancer deaths in men. It would also appear that lung cancer has now displaced coronary heart disease as the single leading cause of excess mortality among smokers in the United States.